Abstract:
:Glufosinate ammonium, a broad-spectrum herbicide, causes convulsion in rodents and humans. Because of the structural similarities between glufosinate and glutamate, the convulsion induced by glufosinate ammonium may be ascribed to glutamate receptor activation. Three N-methyl-D-asparate (NMDA) receptor antagonists, dizocilpine, LY235959, and Compound 40, and an alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate receptor antagonist, NBQX, were coadministrated with glufosinate ammonium (80 mg/kg, intraperitoneally) in mice. Statistical analyses showed that the NMDA receptor antagonists markedly inhibited the convulsions, while the AMPA/kainate receptor antagonist had no effect on the convulsion. These results suggest that the convulsion caused by glufosinate ammonium is mediated through NMDA receptors.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Matsumura N,Takeuchi C,Hishikawa K,Fujii T,Nakaki Tdoi
10.1016/s0304-3940(01)01765-7keywords:
subject
Has Abstractpub_date
2001-05-18 00:00:00pages
123-5issue
1-2eissn
0304-3940issn
1872-7972pii
S0304394001017657journal_volume
304pub_type
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