Glufosinate ammonium induces convulsion through N-methyl-D-aspartate receptors in mice.

Abstract:

:Glufosinate ammonium, a broad-spectrum herbicide, causes convulsion in rodents and humans. Because of the structural similarities between glufosinate and glutamate, the convulsion induced by glufosinate ammonium may be ascribed to glutamate receptor activation. Three N-methyl-D-asparate (NMDA) receptor antagonists, dizocilpine, LY235959, and Compound 40, and an alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate receptor antagonist, NBQX, were coadministrated with glufosinate ammonium (80 mg/kg, intraperitoneally) in mice. Statistical analyses showed that the NMDA receptor antagonists markedly inhibited the convulsions, while the AMPA/kainate receptor antagonist had no effect on the convulsion. These results suggest that the convulsion caused by glufosinate ammonium is mediated through NMDA receptors.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Matsumura N,Takeuchi C,Hishikawa K,Fujii T,Nakaki T

doi

10.1016/s0304-3940(01)01765-7

keywords:

subject

Has Abstract

pub_date

2001-05-18 00:00:00

pages

123-5

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

S0304394001017657

journal_volume

304

pub_type

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