5-HT2A-mu opioid receptor mechanisms in the hypothalamus mediate interleukin-1beta fever in rats.

abstract：:Tryptophan hydroxylase 2 (TPH2) catalyzes the rate-limiting step in the synthesis of brain serotonin (5-HT). In a previous report, a single nucleotide polymorphism in mTph2 (C1473G) reduced 5-HT synthesis by 55%. Mouse strains expressing the 1473C allele, such as C57Bl/6, have higher 5-HT synthesis rates than strains ...

journal_title：Neuroscience letters

authors： Siesser WB,Zhang X,Jacobsen JP,Sotnikova TD,Gainetdinov RR,Caron MG

更新日期：2010-08-30 00:00:00

abstract：:In the present study we have used slice cultures of hippocampus and in situ hybridization techniques in order to study the ability of hippocampal neurons to synthesize CCK mRNA in the absence of extrinsic afferents. Our results show that very similar types of hippocampal neurons express CCK mRNA in culture as in situ....

journal_title：Neuroscience letters

authors： Straube A,Bender R,Otten U,Frotscher M

更新日期：1994-05-19 00:00:00

abstract：:An investigation was made of the effect of presynaptic inhibition on paired-pulse facilitation (PPF) of group Ia afferent excitatory postsynaptic potentials (EPSPs). The main finding from this study was that PPF was enhanced during presynaptic inhibition of compound Ia EPSPs. This increase in PPF is identical to that ...

journal_title：Neuroscience letters

authors： Stuart GJ,Redman SJ

更新日期：1991-05-27 00:00:00

abstract：:In decerebrated rabbits, reflexes were evoked in medial gastrocnemius motoneurones by mechanical stimulation of the heel, using four pinch strengths from 183 (innocuous) to 4577 (noxious) mN. The alpha(2)-adrenoceptor antagonist idazoxan (1-156 microg intrathecal (i.th.) significantly increased responses to pinch stre...

journal_title：Neuroscience letters

authors： Clarke RW,Harris J,Houghton AK

更新日期：2001-08-10 00:00:00

abstract：:Telmisartan is known to block angiotensin (Ang) II type-1 receptors (AT(1)R), and also activate peroxisome proliferator-activated receptor gamma (PPARgamma) signaling. Recently, PPARgamma has been implicated as a regulator of cellular proliferation and inflammatory responses. In the present study, we investigated the ...

journal_title：Neuroscience letters

authors： Haraguchi T,Takasaki K,Naito T,Hayakawa K,Katsurabayashi S,Mishima K,Iwasaki K,Fujiwara M

更新日期：2009-10-30 00:00:00

abstract：:NGP1-01, a member of the pentacycloundecylamine cage compound family, was recently shown to exhibit both NMDA receptor channel blocking and L-type calcium channel antagonism activity. In the present study, focal ischemia was induced in mice by permanent middle cerebral artery occlusion (MCAO) to test for potential neu...

journal_title：Neuroscience letters

authors： Mdzinarishvili A,Geldenhuys WJ,Abbruscato TJ,Bickel U,Klein J,Van der Schyf CJ

更新日期：2005-07-22 00:00:00

abstract：:Schisandra chinensis is commonly used for food and as a traditional remedy for the treatment of neuronal disorders. However, it is unclear which component of S. chinensis is responsible for its neuropharmacological effects. To answer this question, we isolated α-iso-cubebene, a dibenzocyclooctadiene lignin, from S. ch...

journal_title：Neuroscience letters

authors： Park SY,Park SJ,Park NJ,Joo WH,Lee SJ,Choi YW

更新日期：2013-10-25 00:00:00

abstract：:This study investigated the effects of dementia on standing postural adaptation during performance of a visual search task. We recruited 16 older adults with dementia and 15 without dementia. Postural sway was assessed by recording medial-lateral (ML) and anterior-posterior (AP) center-of-pressure when standing with a...

journal_title：Neuroscience letters

authors： Jor'dan AJ,McCarten JR,Rottunda S,Stoffregen TA,Manor B,Wade MG

更新日期：2015-04-23 00:00:00

abstract：:We measured levels of basal and norepinephrine (NE) -induced melatonin release in cultured pineal bodies of rats just after and 2 days after irradiation (20 or 200 Gy) or sham-irradiation. On the day of irradiation, basal and NE-induced melatonin release were not affected by irradiation. Two days after irradiation, ba...

journal_title：Neuroscience letters

authors： Saito K,Shinohara K,Morofushi M,Funabashi T,Mitsushima D,Hata M,Matsubara S,Kimura F

更新日期：2000-04-21 00:00:00

abstract：:Hyperforin is the main antidepressant component of hypericum perforatum (St. John's Wort). Using the push-pull superfusion technique we tested whether hyperforin influences extracellular concentrations of neurotransmitters in the rat locus coeruleus. Hyperforin (10 mg/kg, i.p.) not only enhanced the extracellular leve...

journal_title：Neuroscience letters

authors： Kaehler ST,Sinner C,Chatterjee SS,Philippu A

更新日期：1999-03-12 00:00:00

abstract：:Fluorescent carbocyanine dye (diI) was used to label the glossopharyngeal (IX) nerve in the fixed preparation of the Mexican salamander, axolotl. When the cell bodies were viewed with a confocal laser scanning microscope and Nomarski optics, the cytoplasm was brightly fluorescent, but not the cell nucleus. The cell bo...

journal_title：Neuroscience letters

authors： Nagai T,Oka Y

更新日期：1991-09-30 00:00:00

abstract：:Thioredoxin (TRX) is a small, multifunctional protein with a redox-active site and multiple biological functions that include reducing activity for reactive oxygen intermediates. We assayed TRX by immunohistochemical methods in the rat brain after intraperitoneal injection of 3-nitropropionic acid (3-NP), an irreversi...

journal_title：Neuroscience letters

authors： Sugino T,Nozaki K,Takagi Y,Hattori I,Hashimoto N,Yodoi J

更新日期：1999-11-12 00:00:00

abstract：:The cerebellar Purkinje cell is a major site for neurosteroid formation. We have demonstrated recently that the Purkinje cell actively produces sex steroids, such as estradiol and progesterone, de novo from cholesterol only during rat neonatal life, when cerebellar cortical formation occurs. We have further demonstrat...

journal_title：Neuroscience letters

authors： Shikimi H,Sakamoto H,Mezaki Y,Ukena K,Tsutsui K

更新日期：2004-07-01 00:00:00

abstract：:Mirror neurons, which have now been found in the human and songbird as well as the macaque, respond to both the observation and the performance of the same action. It has been suggested that their matching response properties have evolved as an adaptation for action understanding; alternatively, these properties may a...

journal_title：Neuroscience letters

authors： Catmur C

更新日期：2013-04-12 00:00:00

abstract：:Studies have shown that ageing and several neurological diseases of the central nervous system are often accompanied with increase in concentrations of many cerebrospinal fluid (CSF) proteins. However, few studies have actually looked into the mechanisms behind the increase in CSF protein concentrations. In this study...

journal_title：Neuroscience letters

authors： Chen CP,Chen RL,Preston JE

更新日期：2010-06-07 00:00:00

abstract：:Nucleus rostrolateralis is a distinctive diencephalic nucleus in some ray-finned fishes. In the osteoglossomorph Pantodon, it is a large ovoid nucleus with visual system connections. A topologically and cytoarchitectonically similar nucleus has been found in six species of non-osteoglossomorph fishes, two species of g...

journal_title：Neuroscience letters

authors： Saidel WM,Butler AB

更新日期：1997-06-20 00:00:00

abstract：:It remains unknown if tissue acidosis contributes to neuronal loss during cerebral ischemia. We report that brief intracellular acidification (pH 6.62) results in delayed neuronal loss in cultured hippocampal slices. Cell loss was located primarily in stratum pyramidale and the hilus suggesting that neurons were prefe...

journal_title：Neuroscience letters

authors： Shen H,Chan J,Kass IS,Bergold PJ

更新日期：1995-02-09 00:00:00

abstract：:It has been proposed that the perception of a coherent image necessitates two processes, that is, an ensemble of neurons which synchronizes discharges of individual cells and stimulus-specific gamma-band (gamma) neuronal oscillations which may serve as carrier signals for a temporal code. We tested the hypothesis that...

journal_title：Neuroscience letters

authors： Shumikhina S,Molotchnikoff S

更新日期：1999-09-10 00:00:00

abstract：:Pharmacogenetic studies assessing the role of 5-HT(2A) receptor gene in antipsychotic efficacy yielded conflicting data. Phenotypical heterogeneity of schizophrenia might explain such discrepancies. For example, negative symptoms are known to reflect severity of illness and to restrain therapeutic response. On this ba...

journal_title：Neuroscience letters

authors： Hamdani N,Bonnière M,Adès J,Hamon M,Boni C,Gorwood P

更新日期：2005-03-22 00:00:00

abstract：:Recent findings indicated that the excitotoxicity of glutamate analogues was prevented in the mammalian nervous system by N-methyl-D-aspartate (NMDA) antagonists. The neurodegenerative effects of kainic acid, and the putative protection of MK-801 and 6,7-dinitroquinoxaline-2,3-dione (DNQX), were investigated by morpho...

journal_title：Neuroscience letters

authors： Villani L,Carraro S,Guarnieri T

更新日期：1995-06-09 00:00:00

abstract：:The binding of radioiodinated omega-conotoxin GVIA, a probable Ca channel antagonist, to synaptic plasma membranes of rat brain was examined. Two kinds of specific binding sites were found with apparent dissociation constants of 10 pM and 0.5 nM and maximum binding capacities of 0.5 and 3.4 pmol/mg prot., respectively...

journal_title：Neuroscience letters

authors： Abe T,Koyano K,Saisu H,Nishiuchi Y,Sakakibara S

更新日期：1986-11-11 00:00:00

abstract：:In order to analyze the elementary mechanisms underlying caffeine-induced epileptiform discharges, hippocampal slices of guinea pigs were exposed to this drug. When the bath concentration of caffeine exceeded 0.2 mM, periodically occurring paroxysmal depolarizations (PD) in CA3 neurons appeared. They were accompanied ...

journal_title：Neuroscience letters

authors： Moraidis I,Bingmann D,Lehmenkühler A,Speckmann EJ

更新日期：1991-08-05 00:00:00

abstract：:Avoidance of the nicotine withdrawal syndrome as well as the positive subjective effects of nicotine is the major predisposing factor to motivate nicotine abuse. However, its underlying neurobehavioral mechanisms remain perplexing. In the present study, we investigated the influence of the neurosteroid allopregnanolon...

journal_title：Neuroscience letters

authors： Thakre PP,Tundulwar MR,Chopde CT,Ugale RR

更新日期：2013-04-29 00:00:00

abstract：:The presence of an inhibitor of guanine deaminase in the 'heavy' mito-chondrial fractions of rat brain homogenates has been reported. The results of the present study, using brain homogenates from normal infants who died between ages 1-6 months, low birth weight infants who were brain damaged and died between ages 2 d...

journal_title：Neuroscience letters

authors： Kumar S,Rathi M

更新日期：1976-10-01 00:00:00

abstract：:G protein-coupled receptor kinase-interactor 2 (GIT2) is a signaling scaffold protein that also functions as GTPase-activating protein (GAPs) for ADP-ribosylation factor (Arf) small GTP-binding proteins. GIT2 has been implicated in the regulation of G protein-coupled receptor trafficking and cell adhesion and migratio...

journal_title：Neuroscience letters

authors： Schmalzigaug R,Rodriguiz RM,Phillips LE,Davidson CE,Wetsel WC,Premont RT

更新日期：2009-02-20 00:00:00

abstract：:This study investigated the interaction between physical activity level and responses to transcutaneous spinal direct current stimulation (tsDCS) as reflected in changes in pressure pain threshold (PPT) in the lower extremity. Participants (n = 35, 15 males) consisted of physically active young adults. PPTs were deter...

journal_title：Neuroscience letters

authors： Gibson J,Tremblay F

更新日期：2019-04-17 00:00:00

abstract：:Recently, there has been a lot of interest in the neuroimaging community in exploring fMRI time-series measures of local neuronal activity and excitation/inhibition (E/I) balance in the brain. In this preliminary study we probed the sensitivity of widely used sample entropy (SE) measure at multiple scales to controlle...

journal_title：Neuroscience letters

authors： Maltbie EA,Howell LH,Sun PZ,Miller R,Gopinath KS

更新日期：2020-05-29 00:00:00

abstract：:Social isolation has been widely described to induce compulsive aggressive behavior and produce a large decrease of brain serotonin turnover in male mice. The aggressiveness by isolation in mice has been often used as a means for a better understanding of disturbed behavior in human beings. We found that male ICR whit...

journal_title：Neuroscience letters

authors： Miyachi Y,Kasai H,Ohyama H,Yamada T

更新日期：1994-07-04 00:00:00

abstract：:Pitrazepin is a potent new GABA antagonist which differs from bicuculline in its chemical structure and its interaction with both [3H]muscimol and [3H]flunitrazepam binding sites, whereby the potency of pitrazepin in displacing [3H]muscimol exceeds that of bicuculline by at least a factor of 10. In physiological exper...

journal_title：Neuroscience letters

authors： Gähwiler BH,Maurer R,Wüthrich HJ

更新日期：1984-04-06 00:00:00

abstract：:The autonomic nervous system (ANS) is implicated in maintaining homeostasis of the internal environment in mammals. Therefore, changes occurring in the ANS can cause alterations of physiological phenomena. Ethyl hexanoate (EH) is known as the aroma component of apples. To study the action of ethyl hexanoate on physiol...

journal_title：Neuroscience letters

authors： Horii Y,Fujisaki Y,Misonou Y,Fuyuki R,Nagai K

更新日期：2020-10-15 00:00:00