Abstract:
:Persistent depolarization with a high K+ concentration (30 mM) or sustained activation of N-methyl-D-aspartate (NMDA) receptors (12.5 mM K+ plus 100 microM NMDA) enhance both survival and maturation of mouse cerebellar granule neurons in vitro taking as criteria the amount of protein and DNA and the release of endogenous glutamate respectively. K+ and NMDA neurotrophic effects are associated with c-fos protein expression in the nucleus of these cells suggesting that c-fos protein could play a role in the survival and/or maturation of granule neurons.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Didier M,Roux P,Piechaczyk M,Verrier B,Bockaert J,Pin JPdoi
10.1016/0304-3940(89)90790-8subject
Has Abstractpub_date
1989-12-15 00:00:00pages
55-62issue
1-3eissn
0304-3940issn
1872-7972pii
0304-3940(89)90790-8journal_volume
107pub_type
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