Increased apoptosis in the cingulate sulcus of newborn piglets following transient hypoxia-ischaemia is related to the degree of high energy phosphate depletion during the insult.

abstract：:Somatostatin (SRIF) release from fetal rat cortical cells was stimulated by exposure to 10(-5) M N-methyl-D-aspartate (NMDA) (250 +/- 20% of basal at 96 h). A similar but much less potent effect was seen with kainate (KA) but not with quisqualate (Q) which inhibited SRIF release (KA 150 +/- 13%, Q 65 +/- 18% of basal ...

journal_title：Neuroscience letters

authors： Ham J,Rickards C,Scanlon M

更新日期：1991-08-19 00:00:00

abstract：:Spontaneous gasps were recorded in pentobarbitone-anesthetized adult cats. Mean interval between gasps in 11 cats with their buffer nerves intact was of 65 sec; it was significantly prolonged to 174 sec after unilateral carotid neurotomy and to 403 sec after bilateral carotid neurotomy. Additional sectioning of both a...

journal_title：Neuroscience letters

authors： Zuazo A,Zapata P

更新日期：1980-01-01 00:00:00

abstract：:Within the normal inner ear, there are elements that belong to the immune system. Different inner ear disorders can be explained by autoimmune mechanisms, affecting both humoral and cellular immunity. Melatonin, the principal hormone of the pineal gland, modulates the immune system and extensively participates in the ...

journal_title：Neuroscience letters

authors： Lopez-Gonzalez MA,Guerrero JM,Delgado F

更新日期：1997-11-28 00:00:00

abstract：:Intestinal electric stimulation (IES) has been shown to produce an inhibitory effect on gastric motility and secretion. The possible central mechanism of this entero-gastric inhibitory effect induced by IES is unknown. The objective of this study was to evaluate the effects of various IES on the activity of neurons in...

journal_title：Neuroscience letters

authors： Sun Y,Qin C,Foreman RD,Chen JD

更新日期：2005-09-02 00:00:00

abstract：:Expression levels of amyloid beta (Abeta)-degrading enzymes, insulin degrading enzyme (IDE) and neprilysin (NEP), were examined in transgenic mice with Alzheimer's disease-like neuropathology. After the development of first Abeta plaques in transgenic mice brain, cortical mRNA and protein levels of IDE were significan...

journal_title：Neuroscience letters

authors： Vepsäläinen S,Hiltunen M,Helisalmi S,Wang J,van Groen T,Tanila H,Soininen H

更新日期：2008-06-20 00:00:00

abstract：:Ketogenic diets (KD) have shown beneficial effects in terms of anticonvulsant and anti-epileptogenic properties in several experimental models. However, few studies have investigated the consequences of KD with regards to the anti-epileptogenic and neuroprotective effects in kindling-induced seizures. Here, postnatal ...

journal_title：Neuroscience letters

authors： Jiang Y,Yang Y,Wang S,Ding Y,Guo Y,Zhang MM,Wen SQ,Ding MP

更新日期：2012-02-02 00:00:00

abstract：:Pain is a complex and subjective experience that involves not only the transduction of noxious stimuli by nociceptive fibers, but also the cognitive and emotional processing by the brain. Previous studies on the transmission of nociception suggest that the activation of mesolimbic dopamine (DA) system plays an importa...

journal_title：Neuroscience letters

authors： Zhu J,Chen Y,Lai J,Dang Y,Yan C,Xu M,Chen T

更新日期：2010-06-25 00:00:00

abstract：:Propofol has been demonstrated as a drug of abuse in humans. Our previous study indicated that dexamethasone, a potent agonist of glucocorticoid receptor (GR), inhibited propofol-maintained rat self-administration behaviors by systematic injection. However, the direct effect of GR in the nucleus accumbens (NAc) on pro...

journal_title：Neuroscience letters

authors： Wu B,Lin W,Wang H,Abdullah T,Wang B,Su Y,Ge RS,Lian Q

更新日期：2018-01-01 00:00:00

abstract：:This report describes sensory reinnervation of muscle receptors in humans. In this study, sensory function was investigated in fourteen patients with brachial plexus injury, whose musculocutaneous nerve was surgically sutured with intercostal nerves for reconstruction of elbow flexion. Tapping the intercostal nerve-re...

journal_title：Neuroscience letters

authors： Kanamaru A,Suzuki S,Sibuya M,Homma I,Sai K,Hara T

更新日期：1993-10-14 00:00:00

abstract：:TRPA1 agonists cinnamaldehyde (CA) and mustard oil (allyl isothiocyanate=AITC) induce heat hyperalgesia and mechanical allodynia in human skin, and sensitize responses of spinal and trigeminal dorsal horn neurons to noxious skin heating in rats. TRPA1 is also implicated in cold nociception. We presently used behaviora...

journal_title：Neuroscience letters

authors： Tsagareli MG,Tsiklauri N,Zanotto KL,Carstens MI,Klein AH,Sawyer CM,Gurtskaia G,Abzianidze E,Carstens E

更新日期：2010-04-12 00:00:00

abstract：:Stroke in rodents is associated with increased neurogenesis and the migration of newborn neurons to sites of brain ischemia, where they may participate in repair and recovery. To determine if neurogenesis following stroke yields functional new neurons, we labeled neuronal precursors in the mouse subventricular zone (S...

journal_title：Neuroscience letters

authors： Lai B,Mao XO,Xie L,Jin K,Greenberg DA

更新日期：2008-09-19 00:00:00

abstract：:The longest central nervous system (CNS) specific isoform of the major myelin-associated inhibitor of neurite growth, Nogo-A, has previously been shown to be expressed largely in oligodendrocytes. Using an antibody raised against a recombinant fusion protein comprising amino acids 223-399 of Nogo-A, we show in this re...

journal_title：Neuroscience letters

authors： Liu H,Ng CE,Tang BL

更新日期：2002-08-16 00:00:00

abstract：:Multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are characterized by T cell-mediated autoimmune inflammation of the central nervous system (CNS) leading to oligodendrocyte loss and demyelination accompanied by neuronal cell death. Neuronal TWIK-related acid-sensitive potass...

journal_title：Neuroscience letters

authors： Meuth SG,Kanyshkov T,Melzer N,Bittner S,Kieseier BC,Budde T,Wiendl H

更新日期：2008-12-03 00:00:00

abstract：:In elucidating the possible involvement of histamine (His) in hyperalgesia to heat, the effects of His on the heat response of testicular polymodal receptors were studied in vitro in canine testis-spermatic nerve preparations. His (100 and 1000 microM) induced discharges > 0.5 impulses/s (high-responders) in about one...

journal_title：Neuroscience letters

authors： Mizumura K,Minagawa M,Koda H,Kumazawa T

更新日期：1994-02-28 00:00:00

abstract：:To investigate the actions of glucocorticoids (GCs) on astrocyte functions, interactions of dexamethasone and immediate early genes (IEGs) were studied in cell cultures of rat cerebral cortical astrocytes. Vasoactive intestinal peptide (VIP) induces rapid c-fos mRNA expression and morphological changes (stellation) in...

journal_title：Neuroscience letters

authors： Hisanaga K,Sagar SM,Koistinaho J,Hicks KJ,Sharp FR

更新日期：1993-06-25 00:00:00

abstract：:In astrocytes, ion currents are predominantly carried by K(+) ions, and their potassium channel expression changes during development. Here, we studied ion current generated by voltage-ramp protocols in cultured astrocytes from the corpus callosum of newborn (P0) and 28-day-old (P28) rats. Inward currents measured at ...

journal_title：Neuroscience letters

authors： Montiel-Herrera M,García-Colunga J

更新日期：2010-11-26 00:00:00

abstract：:To investigate whether any specific requirement for extracellular Ca2+ exists in the control synaptic vesicle retrieval, we examined the ability of the divalent cation Ba2+ to substitute for Ca2+ in both vesicle exocytosis and endocytosis. Ba2+ stimulated glutamate release from rat cerebrocortical synaptosomes. Ba2+-e...

journal_title：Neuroscience letters

authors： Cousin MA,Robinson PJ

更新日期：1998-08-28 00:00:00

abstract：:Spinocerebellar ataxias (SCAs) are a group of clinically and genetically heterogeneous neurological diseases. The expansion of unstable microsatellite repeats has been identified as the underlying pathogenic cause of 10 subtypes of autosomal dominant SCAs. The aetiology of sporadic SCA is unknown. The aim of this stud...

journal_title：Neuroscience letters

authors： Majounie E,Wardle M,Muzaimi M,Cross WC,Robertson NP,Williams NM,Morris HR

更新日期：2007-12-11 00:00:00

abstract：:Five picrotoxinin analogues were examined on GABA-gated chloride channels of an identifiable cockroach (Periplaneta americana) motor neurone (Df). Substitution of the bridgehead hydroxyl at the C-6 position of the picrotoxinin molecule by a fluorine atom (fluoropicrotoxinin) had little effect, whereas acetylation of t...

journal_title：Neuroscience letters

authors： Anthony NM,Holyoke CW Jr,Sattelle DB

更新日期：1994-04-25 00:00:00

abstract：:This study examines the effect of acetylcholine (Ach) on parasympathetic vagal neurons in the dorsal motor nucleus of the vagus (DMNX). Patch-clamp techniques were utilized to examine voltage and ligand-gated currents in visualized DMNX neurons in an in vitro slice. Ach (100 microM) activated an inward current, -196.4...

journal_title：Neuroscience letters

authors： Neff RA,Hansen MK,Mendelowitz D

更新日期：1995-08-11 00:00:00

abstract：:We aimed to evaluate the effects of l-dopa use on apparent diffusion coefficient (ADC) values of different brain regions in Parkinson's disease (PD) patients. Thirty-five subjects underwent magnetic resonance imaging (MRI), including 21 PD patients (13 men, 8 women; mean age, 63 years+/-8), and 14 sex and age-matched ...

journal_title：Neuroscience letters

authors： Degirmenci B,Yaman M,Haktanir A,Albayrak R,Acar M,Caliskan G

更新日期：2007-04-18 00:00:00

abstract：:To investigate injury-induced alterations of purinergic P2Y receptor-mediated calcium responses in glial (Müller) cells of the rabbit retina, neural retinae were experimentally detached from the pigment epithelium. The ATP-evoked calcium responses were recorded in the endfeet of glial cells at the vitread surface of r...

journal_title：Neuroscience letters

authors： Uckermann O,Uhlmann S,Weick M,Pannicke T,Francke M,Reichenbach A,Wiedemann P,Bringmann A

更新日期：2003-02-27 00:00:00

abstract：:Glioblastoma is the most common astrocytic brain tumor in humans. Current therapies for this malignancy are mostly ineffective. Photodynamic therapy (PDT), an exciting treatment strategy based on activation of a photosensitizer, has not yet been extensively explored for treating glioblastoma. We used 5-aminolevulinic ...

journal_title：Neuroscience letters

authors： Karmakar S,Banik NL,Patel SJ,Ray SK

更新日期：2007-03-30 00:00:00

abstract：:To clarify the possible involvement of protein kinase (PK) C activation in the excitation and sensitization of polymodal receptors (PMRs), the effects of phorbol 12,13-dibutyrate (PDBu) on PMRs were studied in canine testis-spermatic nerve preparations in vitro. Application of PDBu (10(-7), 10(-6), AND 10(-5) M) for 5...

journal_title：Neuroscience letters

authors： Leng S,Mizumura K,Koda H,Kumazawa T

更新日期：1996-03-08 00:00:00

abstract：:We examined whether the mGluR1 and mGluR5 were involved in development and maintenance of behavioral signs of non-evoked pain and secondary mechanical hyperalgesia induced by knee joint inflammation. Selective mGluR1 antagonist, (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA: 50, 100, 200 microM/25 microl, n=10 per gro...

journal_title：Neuroscience letters

authors： Lee KS,Kim J,Yoon YW,Lee MG,Hong SK,Han HC

更新日期：2007-04-12 00:00:00

abstract：:To assess the role of nasal/tracheal (N/T) breathing in the respiratory patterning of the olfactory bulb (OB) neurons, the activity of 21 units was recorded in 6 anesthetized rats set with a cannula enabling reversible tracheotomy: the rats could inhalate either through nasal pathways or through trachea directly. Shif...

journal_title：Neuroscience letters

authors： Ravel N,Pager J

更新日期：1990-07-31 00:00:00

abstract：:The perception of visual motion is dependent on a set of occipitotemporal regions that are readily accessible to neuromodulation. The current study tested if paired-pulse Transcranial Magnetic Stimulation (ppTMS) could modulate motion perception by stimulating the occipital cortex as participants viewed near-threshold...

journal_title：Neuroscience letters

authors： Gamboa OL,Brito A,Abzug Z,D'Arbeloff T,Beynel L,Wing EA,Dannhauer M,Palmer H,Hilbig SA,Crowell CA,Liu S,Donaldson R,Cabeza R,Davis SW,Peterchev AV,Sommer MA,Appelbaum LG

更新日期：2020-06-21 00:00:00

abstract：:G protein-coupled receptor kinase-interactor 2 (GIT2) is a signaling scaffold protein that also functions as GTPase-activating protein (GAPs) for ADP-ribosylation factor (Arf) small GTP-binding proteins. GIT2 has been implicated in the regulation of G protein-coupled receptor trafficking and cell adhesion and migratio...

journal_title：Neuroscience letters

authors： Schmalzigaug R,Rodriguiz RM,Phillips LE,Davidson CE,Wetsel WC,Premont RT

更新日期：2009-02-20 00:00:00

abstract：:Using the monoclonal antibody, ME 20.4, against the p75 nerve growth factor (NGF) receptor, NGF receptor-like immunoreactivity has been identified in axonal processes innervating the human hippocampus, where previously a loss of reactivity has been reported in a preliminary study of Alzheimer's disease [10]. In an ext...

journal_title：Neuroscience letters

authors： Kerwin JM,Morris CM,Perry RH,Perry EK

更新日期：1992-08-31 00:00:00

abstract：:Studies of cognitive behavior in rodent models of Alzheimer's disease (AD) are the mainstay of academic and industrial efforts to find effective treatments for this disorder. However, in the majority of such studies, the nature of rodent behavioral tests is considerably different from the setting associated with cogni...

journal_title：Neuroscience letters

authors： Piiponniemi TO,Bragge T,Vauhkonen EE,Vartiainen P,Puoliväli JT,Sweeney PJ,Kopanitsa MV

更新日期：2017-05-22 00:00:00