Immunolocalization of dystrobrevin in the astrocytic endfeet and endothelial cells in the rat cerebellum.

Abstract:

:Dystrobrevin is a newly discovered dystrophin-associated protein that is classified as alpha- and beta-dystrobrevin. Previous studies reported that dystrophin, utrophin, syntrophin and beta-dystroglycan were expressed in the cerebellum. In the present study, we examined cellular and subcellular localization of dystrobrevin in the adult rat cerebellum immunohistochemically. Confocal microscopy showed that dystrobrevin was expressed around blood vessels and under the pia mater as dystrophin, utrophin and beta-dystroglycan were. Immunoelectron microscopy demonstrated that dystrobrevin was localized not only in the astrocytic endfeet around blood vessels and under the pia mater, but also in endothelial cells. Considering the fact that dystrobrevin possesses multiple phosphotyrosine kinase residues, these data suggest that dystrobrevin plays a role in blood-brain barrier functions as a component of the dystrophin complex.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Ueda H,Baba T,Terada N,Kato Y,Fujii Y,Takayama I,Mei X,Ohno S

doi

10.1016/s0304-3940(00)00925-3

keywords:

subject

Has Abstract

pub_date

2000-04-07 00:00:00

pages

121-4

issue

2

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(00)00925-3

journal_volume

283

pub_type

杂志文章
  • Effects of the globus pallidus lesion on the induction of c-Fos by dopaminergic drugs in the striatum possibly via pallidostriatal feedback loops.

    abstract::c-Fos is one of the transcription factors contributing to the regulation of the downstream gene expression. Administration of dopamine D1 receptor agonist or D2 receptor antagonist have been known to induce c-Fos expressions in striatal projection neurons. We examined the effects of unilateral ablation of the globus p...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(97)00952-x

    authors: Miwa H,Fuwa T,Nishi K,Mizuno Y

    更新日期:1998-01-16 00:00:00

  • Effects of a prepulse stimulus on the masseteric inhibitory reflex in humans.

    abstract::We investigated the effects of a weak cutaneous stimulus applied to the digital nerves (prepulse) on the masseter inhibitory reflex (MIR) to electrical stimulation of the mental nerve in nine healthy volunteers. The prepulse stimulus, which had no direct effect on the masseter muscle EMG activity, induced a significan...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(96)12574-x

    authors: Gómez-Wong E,Valls-Solé J

    更新日期:1996-04-26 00:00:00

  • Social dominance rank influences wheel running behavior in mice.

    abstract::Dominance hierarchies within social groups determine resource distribution. Resources, such as food and access to mating partners, can act as reinforcers. The present study examined the effect of social rank on access to wheel running-a reinforcing behavior performed by laboratory animals. Mice were identified as domi...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2009.03.098

    authors: Vargas-Pérez H,Sellings L,Grieder T,Díaz JL

    更新日期:2009-07-03 00:00:00

  • Ontogenesis of the axonal circuitry associated with the olfactory system of the rat embryo.

    abstract::The prenatal development of axonal connections in the rat olfactory system was studied using DiI. On day 16 (E16), the olfactory and vomeronasal nerves extended from the olfactory epithelia to the olfactory bulb (OB), the terminal nerve to the telencephalic septum, while axons of mitral and tufted cells reached the an...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(91)90482-9

    authors: Marchand R,Bélanger MC

    更新日期:1991-08-19 00:00:00

  • Staurosporine, a protein kinase inhibitor, attenuates basal forebrain-lesion-induced amnesia and cholinergic neuronal deficit.

    abstract::We have investigated whether administration of staurosporine, which has been reported to induce differentiation in the human neuroblastoma cell in vitro, attenuates amnesia induced by basal forebrain lesion in rats. Multiple dosage of staurosporine at the doses of 0.05 and 0.1 mg/kg (i.p.) attenuated the impaired perf...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(91)90181-r

    authors: Nabeshima T,Ogawa S,Nishimura H,Fuji K,Kameyama T,Sasaki Y

    更新日期:1991-01-14 00:00:00

  • Cytosolic free calcium levels increase with age in rat brain synaptosomes.

    abstract::Calcium homeostasis in synaptosomes is altered during ageing. The cytosolic free calcium concentration, [Ca2+]i was determined in synaptosomes and crude synaptosomal fractions from 3- and 24-month-old rats with the fluorescent indicator quin-2. The [Ca2+]i were around two times higher in 24-month-old rats than in adul...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(88)90234-0

    authors: Martinez A,Vitórica J,Satrústegui J

    更新日期:1988-06-07 00:00:00

  • Age-associated decrease of dopamine-sensitive adenylate cyclase in rabbit renal artery.

    abstract::Using renal arteries from young (6 months), mature (18 months) and old (70 months) rabbits, the effect of dopamine on 3',5'-cyclic adenosine monophosphate (cAMP) generation was studied. No significant differences in basal adenylate cyclase values were found in homogenates of renal artery from young, mature or old rabb...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(84)90394-x

    authors: Amenta F,Cavallotti C,Collier WL,Iacopino L

    更新日期:1984-10-26 00:00:00

  • Histochemical demonstration of separate populations of somatostatin and cholinergic neurons in the rat striatum.

    abstract::Striatal neurons containing acetylcholine and somatostatin were examined using a pharmacohistochemical procedure for acetylcholinesterase and NADPH-diaphorase histochemistry respectively. The use of these two histochemical procedures allowed both cholinergic and somatostatin cells to be visualized simultaneously in si...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(83)90536-0

    authors: Vincent SR,Staines WA,Fibiger HC

    更新日期:1983-02-21 00:00:00

  • Fos expression in the retina of rd/rd mice during the light/dark cycle.

    abstract::An anti-Fos protein antiserum was used to elucidate the diurnal expression of Fos protein in the normal and degenerate rd/rd mice retina. We have found that Fos expression is stimulated in cells of both inner nuclear layer (INL) and ganglion cell layer (GCL) at the onset of light period and reaches its maximum after 2...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(97)00595-8

    authors: Huerta JJ,Llamosas MM,Cernuda-Cernuda R,García-Fernández JM

    更新日期:1997-09-05 00:00:00

  • Circadian rhythm of cortical acetylcholine release as measured by in vivo microdialysis in freely moving rats.

    abstract::Circadian changes in cortical acetylcholine (ACh) release were examined in freely moving rats using long-term in vivo microdialysis and high performance liquid chromatography with electrochemical detection. A microdialysis probe was implanted into the frontal cortex and a dialysate was collected every 30 min for two o...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(91)90316-l

    authors: Kametani H,Kawamura H

    更新日期:1991-11-11 00:00:00

  • Glutathione redox status in mitochondria and cytoplasm differentially and sequentially activates apoptosis cascade in dopamine-melanin-treated SH-SY5Y cells.

    abstract::Neuromelanin (NM)-containing dopaminergic neurons in the substantia nigra are selectively vulnerable in Parkinson's disease (PD), suggesting the involvement of NM in the pathogenesis. NM is composed of protein, lipid, trace metals and melanin component, a mixture of eumelanin produced from dopamine (DA)-quinone and ph...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2009.08.082

    authors: Naoi M,Yi H,Maruyama W,Inaba K,Shamoto-Nagai M,Akao Y,Gerlach M,Riederer P

    更新日期:2009-11-13 00:00:00

  • Neural actions of several substance P antagonists in the rat spinal cord.

    abstract::Four substance P (SP) antagonists were tested on anaesthetized rats, by injecting 8 microgram amounts into the spinal cord (T8-T9), and by observing their effects on the hypothalamo-neurohypophysial responses to a presumably painful stimulus, the superfusion of the hepatic portal vein with 1 microM bradykinin. Only tw...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(83)90444-5

    authors: Stoppini L,Baertschi AJ,Mathison R,Barja F

    更新日期:1983-06-30 00:00:00

  • Neuron type-selective effects of activin on development of the hippocampus.

    abstract::Activin is a member of the transforming growth factor-beta superfamily and affects the viability of hippocampal neurons during postnatal neurogenesis. We used primary hippocampal neuron to study the actions of activin on developing neurons. Continuous treatment of hippocampal cultures with activin suppressed the emerg...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2009.01.074

    authors: Sekiguchi M,Hayashi F,Tsuchida K,Inokuchi K

    更新日期:2009-03-20 00:00:00

  • Nardosinone, a novel enhancer of nerve growth factor in neurite outgrowth from PC12D cells.

    abstract::We isolated nardosinone as a neuritogenic substance from Nardostachys chinensis. Nardosinone did not exhibit the neurotrophic activity but caused a marked enhancement of the nerve growth factor (NGF)-mediated neurite outgrowth from PC12D cells. Nardosinone-induced enhancement of the NGF-action was completely blocked b...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(99)00629-1

    authors: Li P,Matsunaga K,Yamamoto K,Yoshikawa R,Kawashima K,Ohizumi Y

    更新日期:1999-09-24 00:00:00

  • Wnt-3a improves functional recovery through autophagy activation via inhibiting the mTOR signaling pathway after spinal cord injury.

    abstract::Little is known about the effect of wnt-3a on motor nerve function and its specific molecular mechanisms after spinal cord injury (SCI). This study demonstrates that the downregulated expression levels of caspases-3, caspases-9 and chondroitin sulfate proteoglycan (CSPG) proteins and number of proportion of transferas...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2020.135305

    authors: Gao K,Niu J,Dang X

    更新日期:2020-10-15 00:00:00

  • Tryptophan hydroxylase mRNA levels are elevated by repeated immobilization stress in rat raphe nuclei but not in pineal gland.

    abstract::Repeated stress triggers a wide range of adaptive changes in the central nervous system including the elevation of serotonin (5-HT) metabolism and an increased susceptibility to affective disorders. To begin to examine whether these changes are mediated by alterations in gene expression for tryptophan hydroxylase (TPH...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(99)00340-7

    authors: Chamas F,Serova L,Sabban EL

    更新日期:1999-06-04 00:00:00

  • Task-related differences in temporo-parietal cortical activation during human phonatory behaviors.

    abstract::Functional magnetic resonance imaging (fMRI) was used to investigate cortical activity related to differential control of the human phonatory system during a sentence production task. Our focus in this report was on activation of the temporo-parietal (TP) junctional region, suggested by recent models in speech product...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2010.08.017

    authors: Andreatta RD,Stemple JC,Joshi A,Jiang Y

    更新日期:2010-10-22 00:00:00

  • Male sexual behavior is associated with LHRH neuron number in middle-aged rats.

    abstract::LHRH administration is reported to facilitate male sexual behavior. The aim of the present study was to investigate whether male sexual behavior is associated with the number of LHRH neurons in the forebrain in middle-aged rats. Male Long-Evans rats (18-19 months) were assigned to three groups on the basis of sexual p...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(97)00828-8

    authors: Tsai YF,Tsai HW,Tai MY,Huang RL,Peng MT

    更新日期:1997-11-21 00:00:00

  • Calcium Signaling in Schwann cells.

    abstract::In addition to providing structural, metabolic and trophic support to neurons, glial cells of the central, peripheral and enteric nervous systems (CNS, PNS, ENS) respond to and regulate neural activity. One of the most well characterized features of this response is an increase of intracellular calcium. Astrocytes at ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.neulet.2020.134959

    authors: Heredia DJ,De Angeli C,Fedi C,Gould TW

    更新日期:2020-06-11 00:00:00

  • Neuroprotective effects of crocin against traumatic brain injury in mice: Involvement of notch signaling pathway.

    abstract::This study investigated the protective effects and mechanisms of crocin, an extract of saffron, on brain damage after traumatic brain injury (TBI) in mice. C57BL/6 mice were subjected to controlled cortical impact (CCI)-induced TBI. Pretreatment with crocin (20mg/kg) had protective effects against TBI, demonstrated by...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2015.02.016

    authors: Wang K,Zhang L,Rao W,Su N,Hui H,Wang L,Peng C,Tu Y,Zhang S,Fei Z

    更新日期:2015-03-30 00:00:00

  • Pineal 5-methoxytryptophol rhythms in the box turtle: effect of photoperiod and environmental temperature.

    abstract::The effect of different photoperiods and temperatures on pineal 5-methoxytryptophol (ML) content was investigated in male box turtles, Terrapene carolina triunguis. A rhythm in pineal ML was evident in the long photoperiod (18 h light (L)-6 h dark (D] with high daytime levels of 178 +/- 48 pg/gland (means +/- S.E.M.) ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(89)90375-3

    authors: Skene DJ,Vivien-Roels B,Pevet P

    更新日期:1989-03-13 00:00:00

  • Voltage-gated calcium channels contribute to the pattern of the resting discharge in guinea pig medial vestibular nucleus neurons.

    abstract::In brainstem slices of guinea pigs perfused with artificial cerebro-spinal fluid (ACSF), the discharge of all the spontaneously active neurons of the medial vestibular nucleus (MVN) is regular. It has been reported that prolonged exposure to a low Ca(2+) medium could induce these neurons to fire bursts of spikes. In t...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(00)01677-3

    authors: Ris L,Godaux E

    更新日期:2001-01-12 00:00:00

  • Inhibition of acid-sensing ion channels by chlorogenic acid in rat dorsal root ganglion neurons.

    abstract::Chlorogenic acid (CGA) is one of the most abundant polyphenol compounds in the human diet. Recently, it is demonstrated to have potent antinociceptive effect. However, little is understood about the mechanism underlying CGA analgesia. Here, we have found that CGA can exert an inhibitory effect on the functional activi...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2014.03.027

    authors: Qu ZW,Liu TT,Qiu CY,Li JD,Hu WP

    更新日期:2014-05-01 00:00:00

  • Synaptology of cultured olfactory bulb cells.

    abstract::Cultured embryonic mouse olfactory bulb cells formed asymmetric, symmetric, axodendritic, and dendrodendritic synapses. These neurons contained electron lucent, dense core, and coated vesicles. Dense core and coated vesicles had an average diameter of 71 and 80 nm, respectively. Two statistically different populations...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(94)90321-2

    authors: Fracek SP Jr,Guo L,Schafer R

    更新日期:1994-04-11 00:00:00

  • Cerebellar granule cell survival and maturation induced by K+ and NMDA correlate with c-fos proto-oncogene expression.

    abstract::Persistent depolarization with a high K+ concentration (30 mM) or sustained activation of N-methyl-D-aspartate (NMDA) receptors (12.5 mM K+ plus 100 microM NMDA) enhance both survival and maturation of mouse cerebellar granule neurons in vitro taking as criteria the amount of protein and DNA and the release of endogen...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(89)90790-8

    authors: Didier M,Roux P,Piechaczyk M,Verrier B,Bockaert J,Pin JP

    更新日期:1989-12-15 00:00:00

  • Evidence of P2Y-purinoceptor mediated bladder neck smooth muscle post-contractile relaxation in the male mini-pig.

    abstract::The functional role of non-adrenergic non-cholinergic (NANC) nerves in the autonomic control of the male mini-pig bladder neck was investigated in the present study. Electrical stimulation of muscle strips from male mini-pig bladder neck showed biphasic response with initial phasic contraction followed by post-contrac...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(97)00212-7

    authors: Tong YC,Hung YC,Cheng JT

    更新日期:1997-04-11 00:00:00

  • Projections from the rostral ventrolateral medulla to brainstem monoamine neurons in the rat.

    abstract::Following the iontophoretic deposition of Phaseolus vulgaris leucoagglutinin (PHA-L) into the rostral ventrolateral medulla (RVL), two-color immunoperoxidase staining was employed to demonstrate contiguity between PHA-L-immunoreactive (PHA-LI) varicose fibers and boutons and brainstem monoaminergic cells. Black-staine...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(91)90201-4

    authors: Nicholas AP,Hancock MB

    更新日期:1991-01-14 00:00:00

  • Ruthenium red prevents capsaicin-induced neurotoxic action on sensory fibers of the guinea pig ileum.

    abstract::Capsaicin, a neurotoxin which impairs some primary afferent nerve fibers, was locally applied to the mesenteric nerve trunks of adult guinea pigs. The effect of capsaicin was studied on contractile responses of the ileum to mesenteric nerve stimulation (20 Hz). Exposure of the mesenteric nerve to capsaicin (1 microM) ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(89)90218-8

    authors: Jin JG,Takaki M,Nakayama S

    更新日期:1989-11-20 00:00:00

  • Absence/rarity of commonly reported LRRK2 mutations in Indian Parkinson's disease patients.

    abstract::Recent discovery of pathogenic mutations in the leucine-rich repeat kinase 2 (LRRK2) gene in Parkinson's disease (PD) patients in different ethnic groups have raised a hope of diagnostic screening and genetic counseling. We investigated the six most commonly reported mutations in LRRK2 gene among Indian PD patients, u...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2006.04.052

    authors: Punia S,Behari M,Govindappa ST,Swaminath PV,Jayaram S,Goyal V,Muthane UB,Juyal RC,Thelma BK

    更新日期:2006-12-01 00:00:00

  • Morphology of somatosensory evoked fields: inter-hemispheric similarity as a parameter for physiological and pathological neural connectivity.

    abstract::The morphology of somatosensory evoked fields (SEF) following electrical separate stimulation of left and right median nerve in 22 healthy volunteers was explored. The analysis of morphological properties of individual SEFs has been performed, in order to quantify an inter-hemispheric correlation coefficient. Despite ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(00)01171-x

    authors: Tecchio F,Pasqualetti P,Pizzella V,Romani G,Rossini PM

    更新日期:2000-06-30 00:00:00