Abstract：
:Intracellular and extracellular recordings were obtained from layers II-III of slices of adult rat neocortex maintained in vitro. Excitatory postsynaptic potentials (EPSPs) and epileptiform discharges (paroxysmal depolarizing shifts, PDSs) were evoked in the presence of bicuculline methiodide. Responses were monitored before, during, and after bath application of the putative metabotropic glutamate receptor agonists, 1S, 3R-ACPD and L-AP4. Peak EPSP amplitude and both PDS amplitude and duration were reduced during 1S,3R-ACPD application. Area measurements indicate that PDSs were reduced to 51.7 +/- 19.9% of control. Stimulus threshold for evoking a PDS was increased in the presence of 1S,3R-ACPD or L-AP4. Pretreatment of slices with 1S.3R-ACPD did not prevent the generation of epileptiform events when bicuculline subsequently was applied. These results indicate that mGluR activation by 1S,3R-ACPD has significant suppressive effects on evoked epileptiform activity in the adult rat neocortex in vitro.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Burke JP,Hablitz JJdoi
10.1016/0304-3940(94)90111-2subject
Has Abstractpub_date
1994-06-06 00:00:00pages
29-33issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(94)90111-2journal_volume
174pub_type
杂志文章abstract：:Temporal patterns of inflammatory cytokine levels reflect the immune-inflammatory role in pathogenic mechanisms of SOD1 animal model of Amyotrophic Lateral Sclerosis (ALS) and these cytokines have important roles in both toxic and protective functions depending on the stage of disease progression in ALS patients. Eryt...
journal_title：Neuroscience letters
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abstract：:Morphine blocked decremental bar pressing of rats to escape electrical stimulation of aversive midbrain sites. These sites included the dorsal central gray area (DCG), the ventral reticular formation (VRF) and the lateral tegmentum (LT). Naloxone, which had no effect alone, blocked the morphine effects of all three av...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(78)90035-6
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abstract：:Opioids are used in clinical practice to relieve moderate to severe pain. Prolonged use of opioids can lead to a situation of analgesic tolerance and dependence. Several mechanisms are involved in the tolerance to analgesic opioids, including desensitization or internalization of the opioid receptor, elevation of cAMP...
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pub_type： 杂志文章
doi：10.1016/j.neulet.2019.134638
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2000-04-07 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(94)90723-4
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
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更新日期：2002-03-22 00:00:00
abstract：:Considering the multiplicity of symptoms associated with multiple sclerosis (MS), there is possibility that hypocretin system function might be involved in the pathogenesis of the disease. The current study aimed to investigate the hypocretin-1 levels in cerebrospinal fluid (CSF) of MS patients in relation to differen...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2010.02.062
更新日期：2010-04-19 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1991-12-16 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2004.10.072
更新日期：2005-02-10 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2009-06-19 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
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更新日期：2009-09-18 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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更新日期：1989-11-20 00:00:00
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journal_title：Neuroscience letters
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更新日期：2002-05-17 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1987-12-16 00:00:00
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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更新日期：1995-10-13 00:00:00
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journal_title：Neuroscience letters
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更新日期：2012-03-05 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1978-01-01 00:00:00
abstract：:Several studies have suggested an important role for brain-derived neurotrophic factor (BDNF) in the pathophysiology and therapeutics of bipolar disorder (BPD). The mechanisms underlying the therapeutic effects of lithium in BPD seem to involve a direct regulation of neurotrophic cascades. However, no clinical study e...
journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2011-04-20 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(89)90667-8
更新日期：1989-05-22 00:00:00
