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A selective reduction of excitatory amino acids in cerebrospinal fluid of patients with Alzheimer type dementia compared with vascular dementia of the Binswanger type.

Abstract：

:We determined the concentrations of the putative transmitter amino acids in the cerebrospinal fluid of patients with Alzheimer type dementia (ATD) and vascular dementia of the Binswanger type (VDBT). In ATD, aspartate and glutamate concentrations were significantly and selectively reduced, while in VDBT, concentrations of aspartate, glutamate, gamma-aminobutyric acid (GABA) and many other amino acids were decreased non-selectively. In both ATD and VDBT, we found a tendency for all amino acids to increase with progression of the disease, and this reached statistical significance for some amino acids.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Tohgi H,Abe T,Takahashi S,Kimura M

doi

10.1016/0304-3940(92)90321-w

keywords:

subject

Has Abstract

pub_date

1992-07-06 00:00:00

pages

5-8

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(92)90321-W

journal_volume

141

pub_type

杂志文章

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