Abstract：
:The sulphur-containing acidic amino acids (SAAs) display neuroexcitatory actions similar to those of L-glutamate and are widely regarded as bona fide transmitter candidates. In this study, L-cysteine sulphinic acid, L-cysteic acid, DL-homocysteic acid and L-homocysteine sulphinic acid were investigated for their ability to stimulate phosphatidylinositol hydrolysis in rat pup cerebrocortical slices and compared with L-glutamate and the selective agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid ((1S,3R)-ACPD). Each of the SAAs possessed agonist activity at metabotropic glutamate receptors (mGluRs) and, although they exhibited lower efficacy than L-glutamate, they were more potent (EC50s of 401-487 microM compared with 791 microM for L-glutamate). These data are consistent with the possibility that SAAs may have a physiological role as endogenous activators of metabotropic (and presumably ionotropic) excitatory amino acid receptors.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Porter RH,Roberts PJdoi
10.1016/0304-3940(93)90175-ksubject
Has Abstractpub_date
1993-05-14 00:00:00pages
78-80issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(93)90175-Kjournal_volume
154pub_type
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2017-04-24 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(93)90361-n
更新日期：1993-12-12 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
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更新日期：2011-01-03 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2007-10-16 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1976-08-01 00:00:00
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更新日期：1995-08-18 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1994-03-28 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2010.04.076
更新日期：2010-07-12 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2004.05.056
更新日期：2004-08-19 00:00:00
