Abstract:
:PC12 cells, a clonal cell line established from a rat pheochromocytoma, were injected into the subarachnoid space in the lumbar spinal cord of adult rats. These cells invaded the spinal cord as a metastatic tumor and, after 2 weeks, displaced one-third of the cord parenchyma, causing hind limb paralysis. The tumor consisted of densely packed cube-like polygonal cells containing dense core granules. At the tumor-host margins there were no astrocytic or other intervening glial processes. In spite of the destruction and invasion of the spinal cord tissue parenchyma that occurred, no glial reaction could be seen. The endothelial cells of the capillaries in the vascularized tumor are of the attenuated, fenestrated type in contrast to the non-fenestrated type of the host tissue from which they were derived.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Pappas GD,Sagen Jdoi
10.1016/0304-3940(86)90437-4subject
Has Abstractpub_date
1986-09-25 00:00:00pages
59-64issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(86)90437-4journal_volume
70pub_type
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