当前位置： SCI文献检索 > NEUROSCIENCE LETTERS期刊下所有文献 > Dual presence of chromogranin A-like immunoreactivity in a population of endocrine-like cells and in nerve fibers in the human anal canal.

Dual presence of chromogranin A-like immunoreactivity in a population of endocrine-like cells and in nerve fibers in the human anal canal.

Abstract：

:Light microscopic immunohistochemistry was used to investigate the presence and distribution of chromogranin A-like immunoreactivity in the human anal canal. In the anal transitional zone (ATZ), anal duct and anal gland epithelium, a varied number of mostly elongated cells strongly stained for CGA, using an antibody directed to a highly species-conserved region of the CGA molecule or the monoclonal antibody LK2H10. The density of CGA-immunoreactive (ir) cells strikingly increased from the ATZ epithelium towards the anal gland epithelium. CGA-ir cells possessed single processes running perpendicularly to reach the epithelial surface and exhibited basal ramifications that extended parallel to the basal lamina. The number of CGA-ir cells in anal glands exceeded CGA-ir cells in the crypt-bearing colorectal-type mucosa. The abundant population of CGA-ir cells in the anal canal most likely represents a population of specialized endocrine or paracrine cells. CGA-like immunoreactivity was also present in anocutaneous Merkel cells. A sparse number of vascular and non-vascular CGA-ir varicose nerve fibers was present throughout the layers and rostrocaudal divisions of the anal canal and in the perianal skin. Proposed functions of CGA in neuroendocrine cells and nerves of the anal canal include calcium binding and regulation, secretory granule matrix formation, and generation of bioactive peptides.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Weihe E,Hörsch D,Eiden LE,Hartschuh W

doi

10.1016/0304-3940(91)90394-9

subject

Has Abstract

pub_date

1991-09-16 00:00:00

pages

190-4

issue

2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(91)90394-9

journal_volume

130

pub_type

杂志文章

相关文献

NEUROSCIENCE LETTERS文献大全
  • Antagonism of orexin type 1 receptors in the locus coeruleus attenuates signs of naloxone-precipitated morphine withdrawal in rats.

    abstract：:It has been shown that orexin neuropeptides contribute to morphine-induced physical dependence. The locus coeruleus (LC), which receives a dense extra-hypothalamic orexinergic projection, is a key brain region implicated in the expression of somatic signs of morphine withdrawal syndrome. The aim of the present study i...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2010.07.050

    authors： Azizi H,Mirnajafi-Zadeh J,Rohampour K,Semnanian S

    更新日期：2010-10-04 00:00:00

  • Sex differences in the responses of orexin neurons in the lateral hypothalamic area and feeding behavior to fasting.

    abstract：:Because there are sex differences in feeding-related behavior and orexin neurons are involved in feeding, we looked for a possible sex difference in the response of orexin neurons in the lateral hypothalamic area to fasting, using the phosphorylated cyclic AMP response element-binding protein (pCREB) as a marker of ne...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2009.07.035

    authors： Funabashi T,Hagiwara H,Mogi K,Mitsushima D,Shinohara K,Kimura F

    更新日期：2009-09-29 00:00:00

  • The cannabinoid antagonist SR141716A facilitates memory acquisition and consolidation in the mouse elevated T-maze.

    abstract：:Delta9-THC and synthetic cannabinoids produce memory impairment in humans as well as in laboratory animals. The high concentration of cannabinoid CB1 receptors and the presence of endocannabinoids in the hippocampus suggest that a cannabinoid neurochemical system may play a role in learning and memory processes. Thus,...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2005.01.049

    authors： Takahashi RN,Pamplona FA,Fernandes MS

    更新日期：2005-06-03 00:00:00

  • Functional neuroimaging of duration discrimination on two different time scales.

    abstract：:Analyses of neural mechanisms of duration processing are essential for the understanding of psychological phenomena which evolve in time. Different mechanisms are presumably responsible for the processing of shorter (below 500 ms) and longer (above 500 ms) events but have not yet been a subject of an investigation wit...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2009.12.040

    authors： Gutyrchik E,Churan J,Meindl T,Bokde AL,von Bernewitz H,Born C,Reiser M,Pöppel E,Wittmann M

    更新日期：2010-01-29 00:00:00

  • 5-Hydroxytryptamine increases spontaneous activity of subthalamic neurons in the rat.

    abstract：:The effect of 5-hydroxytryptamine on the spontaneous activity of neurons of the subthalamic nucleus was examined by recording the extracellular unitary activity in an in vitro slice preparation. The most frequent response to 5-hydroxytryptamine (84% of 57 neurons tested) was an increase (twofold of basal at 10 microM)...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(95)11597-p

    authors： Flores G,Rosales MG,Hernández S,Sierra A,Aceves J

    更新日期：1995-06-02 00:00:00

  • Monoamine oxidase activity in chick cerebral microvessels.

    abstract：:In chick brain microvessels, monoamine oxidase activity using catecholamines (dopamine and noradrenaline) and indoleamines (serotonin and tryptamine) as substrates was higher than that measured in synaptosomes and free mitochondria. In contrast, phenylalkyamines such as tyramine and 2-phenylethylamine were more deamin...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(86)90075-3

    authors： Durand M

    更新日期：1986-12-12 00:00:00

  • Apamin produces selective improvements of learning in rats.

    abstract：:The effect of apamin on learning was examined using two behavioral tasks where the animals were subjected to two trials separated by a 24h interval. In the Y maze task, apamin administered before the acquisition session did not enhance performance on both the acquisition session and the restitution session. In the sec...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2005.05.050

    authors： Deschaux O,Bizot JC

    更新日期：2005-09-23 00:00:00

  • Subacute hemorrhage and resolution of edema in Rose Bengal stroke model in rats coincides with improved sensorimotor functions.

    abstract：:The Rose Bengal model in rats is widely used to study brain plasticity, functional recovery and restorative therapies. The present study evaluated temporal profiles of hemorrhage and edema by magnetic resonance imaging (MRI) in rats in relation to sensorimotor impairment after photochemically induced cortical infarct....

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2007.09.043

    authors： Jolkkonen J,Jokivarsi K,Laitinen T,Gröhn O

    更新日期：2007-11-27 00:00:00

  • Thermogenetic stimulation of single neocortical pyramidal neurons transfected with TRPV1-L channels.

    abstract：:Thermogenetics is a promising innovative neurostimulation technique, which enables robust activation of single neurons using thermosensitive cation channels and IR stimulation. The main advantage of IR stimulation compared to conventional visible light optogenetics is the depth of penetration (up to millimeters). Due ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2018.09.038

    authors： Roshchin M,Ermakova YG,Lanin AA,Chebotarev AS,Kelmanson IV,Balaban PM,Zheltikov AM,Belousov VV,Nikitin ES

    更新日期：2018-11-20 00:00:00

  • Blockade of D1-like dopamine receptors within the ventral tegmental area and nucleus accumbens attenuates antinociceptive responses induced by chemical stimulation of the lateral hypothalamus.

    abstract：:It was established that stimulation of the lateral hypothalamus (LH) can induce antinociception. Previous studies showed a role for the ventral tegmental area (VTA) and nucleus accumbens (NAc) in antinociception induced by LH stimulation through the orexinergic system. In this study, we tried to assess the involvement...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2015.05.047

    authors： Moradi M,Fatahi Z,Haghparast A

    更新日期：2015-07-10 00:00:00

  • Reproduction of scalp acupuncture therapy on strokes in the model rats, spontaneous hypertensive rats-stroke prone (SHR-SP).

    abstract：:Scalp acupuncture (SA) therapy on strokes has been empirically established and widely used in clinics in China. SA is particularly effective at ameliorating paralyses and speech disturbances, and the recovery rate is twice that for those treated with medication alone. To investigate the effects of SA on a scientific b...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(02)01032-7

    authors： Inoue I,Chen L,Zhou L,Zeng X,Wang H

    更新日期：2002-11-29 00:00:00

  • Anti-prion activity generated by a novel vaccine formulation.

    abstract：:Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSE) of domestic and wild cervids in North America. To address possible prevention regimens for CWD, we have used a mouse model system and the Rocky Mountain Laboratory (RML) mouse-adapted scrapie prion strain to screen efficacy of potential v...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2007.10.015

    authors： Pilon J,Loiacono C,Okeson D,Lund S,Vercauteren K,Rhyan J,Miller L

    更新日期：2007-12-18 00:00:00

  • Non-conscious neural regulation against mortality concerns.

    abstract：:Social psychological studies have shown that an experience of threat such as an encounter with death-related stimuli and social exclusion results in tuning toward positive emotional information. Neuroimaging studies have also begun to uncover the neural basis of threat coping, and in this literature, the activity of t...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2013.07.027

    authors： Yanagisawa K,Kashima ES,Moriya H,Masui K,Furutani K,Nomura M,Yoshida H,Ura M

    更新日期：2013-09-27 00:00:00

  • Protective effects of a radical scavenger edaravone on oligodendrocyte precursor cells against oxidative stress.

    abstract：:Oligodendrocyte precursor cells (OPCs) play critical roles in maintaining the number of oligodendrocytes in white matter. Previously, we have shown that oxidative stress dampens oligodendrocyte regeneration after white matter damage, while a clinically proven radical scavenger, edaravone, supports oligodendrocyte repo...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2018.01.018

    authors： Takase H,Liang AC,Miyamoto N,Hamanaka G,Ohtomo R,Maki T,Pham LD,Lok J,Lo EH,Arai K

    更新日期：2018-03-06 00:00:00

  • Evidence that the neuronal nitric oxide synthase inhibitor 7-nitroindazole inhibits monoamine oxidase in the rat: in vivo effects on extracellular striatal dopamine and 3,4-dihydroxyphenylacetic acid.

    abstract：:The present study investigated in vivo the kinetic of the changes in rat striatal extracellular concentrations of dopamine (DA), and its monoamine oxidase (MAO)-derived metabolite 3,4-dihydroxyphenylacetic acid (DOPAC), following administration either of nitric oxide (NO) synthase (NOS) inhibitors 7-nitroindazole (7-N...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(99)00139-1

    authors： Desvignes C,Bert L,Vinet L,Denoroy L,Renaud B,Lambás-Señas L

    更新日期：1999-04-02 00:00:00

  • Two-component models of reaching: evidence from deafferentation in a Fitts' law task.

    abstract：:Both feedforward and feedback mechanisms are used to ensure accurate movements. Feedback information comes primarily from vision and proprioception; the relative contributions of these modalities to on-line control of action and internal model maintenance remain unclear. We report data from an experiment in which a ch...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2009.01.002

    authors： Medina J,Jax SA,Coslett HB

    更新日期：2009-02-27 00:00:00

  • Localization of dystrophin in the Purkinje cells of normal mice.

    abstract：:A monoclonal antibody that reacts with a mid rod fragment of dystrophin was used to localize this protein in the central nervous system (CNS). Due to a low abundance of dystrophin in the CNS, an immunoperoxidase reaction amplified with a biotin-avidin system was used. All Purkinje cells in normal mice were dystrophin ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(92)90309-u

    authors： Huard J,Tremblay JP

    更新日期：1992-03-16 00:00:00

  • Agmatine does not have activity at alpha 2-adrenoceptors which modulate the firing rate of locus coeruleus neurones: an electrophysiological study in rat.

    abstract：:Agmatine (decarboxylated arginine) has been proposed as an endogenous ligand for non-adrenoceptor, imidazoline binding sites, but also binds to alpha 2-adrenoceptors. The interaction of agmatine with alpha 2-adrenoceptors was evaluated by studying the effect of agmatine on the firing rate of locus coeruleus (LC) neuro...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(96)13180-3

    authors： Pineda J,Ruiz-Ortega JA,Martín-Ruiz R,Ugedo L

    更新日期：1996-11-22 00:00:00

  • Cortical and medullary somatosensory projections to the cochlear nuclear complex in the hedgehog tenrec.

    abstract：:Various tracer substances were injected into the spinal cord, the dorsal column nuclei, the trigeminal nuclear complex and the somatosensory cortex in Madagascan hedgehog tenrecs. With the exception of the cases injected exclusively into the spinal cord all injections gave rise to sparse, but distinct anterograde proj...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(96)13305-x

    authors： Wolff A,Künzle H

    更新日期：1997-01-17 00:00:00

  • Acute excitotoxicity in chick retina caused by the unusual amino acids BOAA and BMAA: effects of MK-801 and kynurenate.

    abstract：:beta-N-Oxalylamino-L-alanine (BOAA) and beta-N-methylamino-L-alanine (BMAA) were tested for their ability to produce acute excitotoxicity in in embryonic chick retina. gamma-Aminobutyric acid (GABA) release and histology were monitored in retina treated with various concentrations of BOAA, BMAA, kainate (KA), N-methyl...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(89)90093-1

    authors： Zeevalk GD,Nicklas WJ

    更新日期：1989-07-31 00:00:00

  • Localization and trafficking of endogenous anterior pharynx-defective 1, a component of Alzheimer's disease related gamma-secretase.

    abstract：:Anterior pharynx-defective 1 (Aph-1) is a multi-spanning membrane protein and an integral component of the high molecular weight gamma-secretase complex that also contains presenilin, nicastrin, and Pen-2. In order to clarify the existence of an endogenous fragment of Aph-1 and dissect the localization and processing ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2010.07.061

    authors： Sanjo N,Katayama T,Hasegawa H,Jin H,Duthie M,Mount HT,Mizusawa H,St George-Hyslop P,Fraser PE

    更新日期：2010-10-08 00:00:00

  • Duration-dependent growth of N1m for speech-modulated bone-conducted ultrasound.

    abstract：:Bone-conducted ultrasound (BCU) modulated by speech sound is recognized as speech sound and activates the auditory cortex similar to audible sound. To investigate the mechanisms of perception, the effects of stimulus duration on N1m were compared among air-conducted audible speech sound (AC speech), AC speech with car...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2011.03.044

    authors： Okayasu T,Nishimura T,Yamashita A,Nakagawa S,Nagatani Y,Yanai S,Uratani Y,Hosoi H

    更新日期：2011-05-09 00:00:00

  • Dementia alters standing postural adaptation during a visual search task in older adult men.

    abstract：:This study investigated the effects of dementia on standing postural adaptation during performance of a visual search task. We recruited 16 older adults with dementia and 15 without dementia. Postural sway was assessed by recording medial-lateral (ML) and anterior-posterior (AP) center-of-pressure when standing with a...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2015.03.014

    authors： Jor'dan AJ,McCarten JR,Rottunda S,Stoffregen TA,Manor B,Wade MG

    更新日期：2015-04-23 00:00:00

  • 6-Hydroxydopamine lesions of the ventral tegmental area suppress ghrelin's ability to elicit food-reinforced behavior.

    abstract：:While past research suggests that ghrelin stimulates appetite through an action on hypothalamic signaling, recent evidence indicates that the peptide acts via mesotelencephalic dopamine neurons to alter appetitive motivation. In the present study, rats were trained to operantly respond for food on a progressive ratio ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2011.05.034

    authors： Weinberg ZY,Nicholson ML,Currie PJ

    更新日期：2011-07-20 00:00:00

  • Methionine diet-induced hyperhomocysteinemia accelerates cerebral aneurysm formation in rats.

    abstract：BACKGROUND AND PURPOSE:The pathophysiology of cerebral aneurysms (CA) is linked to chronic inflammation. Endothelial damage is one of the first changes in CA walls resulted from inflammation. It has been shown that increase in plasma homocysteine (Hcy) impairs vascular endothelium and correlates with the development of...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2011.02.076

    authors： Xu Y,Tian Y,Wei HJ,Dong JF,Zhang JN

    更新日期：2011-04-25 00:00:00

  • Differential expression of miRNA-146a-regulated inflammatory genes in human primary neural, astroglial and microglial cells.

    abstract：:MicroRNA-146a (miRNA-146a) is an inducible, 22 nucleotide, small RNA over-expressed in Alzheimer's disease (AD) brain. Up-regulated miRNA-146a targets several inflammation-related and membrane-associated messenger RNAs (mRNAs), including those encoding complement factor-H (CFH) and the interleukin-1 receptor associate...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2011.05.044

    authors： Li YY,Cui JG,Dua P,Pogue AI,Bhattacharjee S,Lukiw WJ

    更新日期：2011-07-20 00:00:00

  • The effect of pentylenetetrazole-kindling on the extracellular glutamate and taurine levels in the frontal cortex of rats.

    abstract：:We studied the extracellular concentration of glutamate and taurine in the frontal cortex of freely-moving pentylenetetrazole (PTZ) kindled rats using an in vivo microdialysis. A significant and sustained increase in the glutamate level was observed in the kindled rats, in contrast, a slight and delayed increase was o...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(00)00838-7

    authors： Li Z,Yamamoto Y,Morimoto T,Ono J,Okada S,Yamatodani A

    更新日期：2000-03-17 00:00:00

  • Effect of retinoic acid and ethanol on retinoic acid receptor beta and glial fibrillary acidic protein mRNA expression in human astrocytoma cells.

    abstract：:This work explores the hypothesis that perturbations caused by ethanol on the regulatory role of retinoids in brain development may be a mechanism involved in the neuropathology of fetal alcohol syndrome. The interaction of ethanol and retinoic acid (RA) on RA receptor (RAR) beta and glial fibrillary acidic protein (G...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(00)01538-x

    authors： Grummer MA,Salih ZN,Zachman RD

    更新日期：2000-11-17 00:00:00

  • Nitric oxide facilitates N-methyl-D-aspartate-induced burst firing in dopamine neurons from rat midbrain slices.

    abstract：:Dopamine (DA) neurons in the ventral tegmental area and substantia nigra pars compacta were induced to fire in bursts with application of N-methyl-D-aspartate (NMDA, 20 microM) and apamin (100 nM) while recording intracellularly in the rat brain slice. L-Arginine (300 microM), a substrate for nitric oxide (NO) product...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(98)00737-x

    authors： Cox BA,Johnson SW

    更新日期：1998-10-23 00:00:00

  • Noradrenaline neurotoxin DSP-4 effects on sleep and brain temperature in the rat.

    abstract：:N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) has a selective degenerative effect on noradrenergic fibers originating from locus coeruleus (LC) neurons. In the present study, we studied its effect on vigilance states and brain temperature by continuous recordings for periods of 1-5 days and 2-4 weeks following ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(98)00333-4

    authors： González MM,Debilly G,Valatx JL

    更新日期：1998-05-29 00:00:00