Increased ponto-geniculo-occipital (PGO) wave frequency following central administration of neostigmine.

Abstract:

:In all mammals so far investigated the occurrence of ponto-geniculo-occipital (PGO) waves precedes the onset and maintenance of desynchronized (D) sleep. As unitary electrographic events, PGO waves provide an index for quantitative evaluation of physiological D sleep or the D sleep-like state evoked by centrally administered acetylcholinesterase inhibitors. The present study characterized PGO wave frequency and time course following central administration of neostigmine bromide (Neo). The results show that Neo produced a dose-dependent increase in PGO wave frequency and time course when injected into brainstem regions other than areas containing putative PGO wave generating neurons. These results support the concept that PGO waves and D sleep are generated by an anatomically distributed network of cholinoceptive neurons.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Baghdoyan HA,Lydic R,Callaway CW,Hobson JA

doi

10.1016/0304-3940(87)90269-2

subject

Has Abstract

pub_date

1987-12-04 00:00:00

pages

278-84

issue

3

eissn

0304-3940

issn

1872-7972

pii

0304-3940(87)90269-2

journal_volume

82

pub_type

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