Quinolinic acid protects rat cerebellar granule cells from glutamate-induced apoptosis.

abstract：:In an attempt to elucidate the possible mechanisms involved in the development of the thermoregulatory disturbances induced by systemic capsaicin treatment, the effects of 5-HT injected into the preoptic region or into the cisterna magna on the body temperature and on tail skin vasodilation were studied in control and...

journal_title：Neuroscience letters

authors： Hajós M,Obál F Jr,Jancsó G,Obál F

更新日期：1985-02-28 00:00:00

abstract：:Reciprocal Ia inhibition from ankle flexors to extensors was studied in five patients with spasticity due to incomplete traumatic spinal cord lesions. Nine healthy subjects were tested as controls. Excitability of the soleus motoneuron pool was estimated by H-reflex testing in the resting state. Ia inhibition was acti...

journal_title：Neuroscience letters

authors： Boorman G,Hulliger M,Lee RG,Tako K,Tanaka R

更新日期：1991-06-10 00:00:00

abstract：:We have recently observed that the free radical-generating mixture of xanthine and xanthine oxidase (X/XO) can suppress the inhibitory effects of adenosine on synaptic transmission in the hippocampus, but that this action can be mimicked by xanthine alone. We have now clarified the mechanism of these interactions by u...

journal_title：Neuroscience letters

authors： Shahraki A,Fukunari A,Stone TW

更新日期：2004-07-29 00:00:00

abstract：:Recent evidence suggests a predominant role for potassium (K) efflux in apoptotic cell death yet there exists controversy as to the exact nature of this involvement of K. In the present study we tested the anti-apoptotic efficacy of K channel blockers, tetraethylammonium Cl (TEA), and high extracellular K, the sodium ...

journal_title：Neuroscience letters

authors： Small DL,Tauskela J,Xia Z

更新日期：2002-12-13 00:00:00

abstract：:Treatment with agmatine, decarboxylated arginine, proved to be non-toxic and to exert neuroprotective effects in several models of neurotoxic and ischemic brain and spinal cord injuries. Here we sought to find out whether agmatine treatment would also prove beneficial in a rat spinal cord ischemia model (balloon occlu...

journal_title：Neuroscience letters

authors： Gilad GM,Gilad VH

更新日期：2000-12-22 00:00:00

abstract：:Substance P (SP) plays an important role in sensitization of spinal cord neurons. In this study, we investigated SP-induced calcium activities in cultured rat spinal cord neurons with confocal laser scanning microscopy. Our results showed that SP increased [Ca(2+)](i) by calcium entry rather than release from intracel...

journal_title：Neuroscience letters

authors： Zhou ZS,Shu YS,Zhao ZQ

更新日期：2000-06-16 00:00:00

abstract：:Using the Golgi silver impregnation technique the present study examines the morphology and development of presumptive local circuit neurons in lamina III of the rat lumbar spinal cord. These neurons generate local axonal plexuses which remain within the gray matter and dendritic trees which arborize in lamina III and...

journal_title：Neuroscience letters

authors： Beal JA,Russell CT,Knight DS

更新日期：1988-03-21 00:00:00

abstract：:The physiological role of mGluR1-induced inward current in a Purkinje neuron was studied in a cerebellar slice preparation. In a voltage-clamp condition, application of a mGluR1 agonist (RS)-3,5-dihydroxyphenylglycine (DHPG) induced both the transient and sustained phases of inward currents, which were blocked by simu...

journal_title：Neuroscience letters

authors： Yamakawa Y,Hirano T

更新日期：1999-12-24 00:00:00

abstract：:Comparable to the anti-craving compound acamprosate, caroverine reduces alcohol withdrawal symptoms by an antagonism at ionotropic glutamate receptors and a blockade of calcium channels. The present study examines the effect of caroverine in a craving model, in which acamprosate has proved effective before. A place av...

journal_title：Neuroscience letters

authors： Kratzer U,Schmidt WJ

更新日期：2003-10-02 00:00:00

abstract：:In this study we examined the presence of dopamine D1 receptors in monkey amniotic epithelial cells (MAEC) using RT-PCR and radioligand binding experiments. We found that MAEC express D1 receptor mRNA that is having 99% homology with human dopamine D1 receptors. Saturation binding studies using [3H]SCH-23390 showed a ...

journal_title：Neuroscience letters

authors： Elwan MA,Ishii T,Ono F,Sakuragawa N

更新日期：1999-02-26 00:00:00

abstract：:Anterior pharynx-defective 1 (Aph-1) is a multi-spanning membrane protein and an integral component of the high molecular weight gamma-secretase complex that also contains presenilin, nicastrin, and Pen-2. In order to clarify the existence of an endogenous fragment of Aph-1 and dissect the localization and processing ...

journal_title：Neuroscience letters

authors： Sanjo N,Katayama T,Hasegawa H,Jin H,Duthie M,Mount HT,Mizusawa H,St George-Hyslop P,Fraser PE

更新日期：2010-10-08 00:00:00

abstract：:Aripiprazole, a novel atypical antipsychotic drug, can significantly increase dopamine (DA) levels in the prefrontal cortex of rats, but only at low doses below 1mg/kg. The aim of the present work was to test the effect of aripiprazole (0, 0.1, 0.3, 3 and 30 mg/kg, i.p.) on extracellular levels of monoamines in the pr...

journal_title：Neuroscience letters

authors： Zocchi A,Fabbri D,Heidbreder CA

更新日期：2005-10-28 00:00:00

abstract：:Recently, the potent cholinesterase inhibitor (-)-huperzine A (HupA) was demonstrated to protect neuronal and glial cells against the cytotoxicity of beta-amyloid (Abeta). Since the unnatural (+)-HupA is a much less potent inhibitor, it was of interest to examine the stereoselectivity of cellular protection by the two...

journal_title：Neuroscience letters

authors： Zhang HY,Liang YQ,Tang XC,He XC,Bai DL

更新日期：2002-01-14 00:00:00

abstract：:Acrylamide is a chemical known to produce neurotoxicity in animals, as well as in humans. The mechanism of acrylamide-induced neurotoxicity is not fully known. However, recent studies have revealed that acrylamide affects the dopaminergic system. Therefore, the aim of this study was to investigate the effect of acryla...

journal_title：Neuroscience letters

authors： Tareke E,Lyn-Cook BD,Duhart H,Newport G,Ali S

更新日期：2009-07-17 00:00:00

abstract：:Direct exposure of rats to tobacco smoke induces antinociception. We presently investigated if this antinociception is mediated via nicotinic and/or mu-opioid receptors. Adult male rats were surgically implanted with Alzet osmotic minipumps that delivered either saline (control), the nicotinic antagonist mecamylamine,...

journal_title：Neuroscience letters

authors： Simons CT,Cuellar JM,Moore JA,Pinkerton KE,Uyeminami D,Carstens MI,Carstens E

更新日期：2005-12-02 00:00:00

abstract：:Our previous studies have shown that acupuncture attenuates morphine self-administration and sensitization behavior as well as withdrawal signs. The present study was designed to investigate the role of acupuncture in the reinstatement of morphine seeking. Male Sprague-Dawley rats weighing 270-300 g were subjected to ...

journal_title：Neuroscience letters

authors： Lee BH,Ma JH,In S,Kim HY,Yoon SS,Jang EY,Yang CH

更新日期：2012-10-31 00:00:00

abstract：:Neuroblastoma cells differentiate in response to retinoic acid and cyclic AMP. We have examined the expression of retinoic acid receptors (RARs) in relation to neuroblastoma differentiation and show that short term exposure of SK N SH, SH SY 5Y AND GI LI N cells to physiological concentrations of retinoic acid results...

journal_title：Neuroscience letters

authors： Lovat PE,Pearson AD,Malcolm A,Redfern CP

更新日期：1993-11-12 00:00:00

abstract：:The effects of nifedipine, niguldipine, nimodipine and nitrendipine on the high K+-induced intracellular Ca2+ ([Ca2+]i) transient in dibutyryl cAMP-differentiated neuroblastoma x glioma hybrid NG 108-15 cells were studied by using the fluorescent Ca2+ indicator fura-2. It was observed that nifedipine at the concentrat...

journal_title：Neuroscience letters

authors： Li SN,Bräter M,Andreas K

更新日期：1997-07-18 00:00:00

abstract：:Vitamin B12 is implicated in methylation processes. Myelin basic protein is methylated on one arginine group. A defect in methylation could produce an unstable protein, leading to neurological disorders. In order to study myelin basic protein, we have developed the cultures of newborn rat oligodendrocytes in vitamin B...

journal_title：Neuroscience letters

authors： Sponne IE,Gaire D,Stabler SP,Droesch S,Barbé FM,Allen RH,Lambert DA,Nicolas JP

更新日期：2000-07-21 00:00:00

abstract：:Event-related alpha (10 Hz) oscillations in the EEG were measured in cats by means of intracranial electrodes. Simultaneous recordings were made from auditory and visual cortex while auditory and visual stimuli were applied (in separate sessions). Frequency domain analysis of the EEG responses showed marked alpha comp...

journal_title：Neuroscience letters

authors： Schürmann M,Başar-Eroglu C,Başar E

更新日期：1998-01-02 00:00:00

abstract：:The objective of this study was to test the hypothesis that 4 weeks of lithium administration would be associated with changes in brain gray and white matter volumes in healthy individuals. Thirteen right-handed healthy volunteers (6 females, mean age=25.9+/-10.0 years) were studied. 3D SPGR MRIs (TR=25 ms, TE=5 ms, s...

journal_title：Neuroscience letters

authors： Monkul ES,Matsuo K,Nicoletti MA,Dierschke N,Hatch JP,Dalwani M,Brambilla P,Caetano S,Sassi RB,Mallinger AG,Soares JC

更新日期：2007-12-11 00:00:00

abstract：:To understand the genetic origin of I2020T mutation in the kinase domain of leucine rich repeat kinase 2 (LRRK2), we investigated the original PARK8 Japanese family (Sagamihara family) and a German family (family 32), both of which were found to harbor I2020T as the causal mutation for autosomal dominant familial Park...

journal_title：Neuroscience letters

authors： Ohta E,Hasegawa K,Gasser T,Obata F

更新日期：2007-04-24 00:00:00

abstract：:The level of endogenous nerve growth factor (NGF) in rat sciatic nerve was determined using a highly sensitive two-site enzyme immunoassay. After crushing this nerve NGF accumulated linearly distal to the crush during the first 12 h to reach levels 13-fold higher than in the uncrushed contralateral side. In contrast, ...

journal_title：Neuroscience letters

authors： Korsching S,Thoenen H

更新日期：1983-08-19 00:00:00

abstract：:Transcranial direct current stimulation (tDCS) is a non-invasive technique that moderates cognitive and motor function. The effects of tDCS on cognitive and motor tasks vary among individuals. However, the source of the inter-individual variability remains unknown. The purpose of the present study was to examine wheth...

journal_title：Neuroscience letters

authors： Kasahara K,Tanaka S,Hanakawa T,Senoo A,Honda M

更新日期：2013-06-17 00:00:00

abstract：:The dopaminergic system has been proposed to be one of the innervations in controlling the mammalian pineal gland function. The dopamine receptors have been characterized in the pineal and the biphasic effects of dopamine on melatonin production have been demonstrated. Recently, the site of dopamine transporter (DAT),...

journal_title：Neuroscience letters

authors： Phansuwan-Pujito P,Boontem P,Chetsawang B,Ebadi M,Govitrapong P

更新日期：2006-07-31 00:00:00

abstract：:Parkinson's disease (PD) is characterized by the selective loss of dopaminergic (DAergic) neurons in the substantia nigra and the subsequent depletion of dopamine (DA). This study assessed the protective effects of costunolide on DA-induced apoptosis in human DAergic SH-SY5Y cells, and its regulation of DA metabolism-...

journal_title：Neuroscience letters

authors： Ham A,Lee SJ,Shin J,Kim KH,Mar W

更新日期：2012-01-24 00:00:00

abstract：:Despite much study since its discovery in 1995, the effects of orphanin FQ/nociceptin (OFQ/N), the endogenous ligand of the 'orphan' opioid receptor, on nociceptive sensitivity remain unclear. Different laboratories have variously reported hyperalgesic, analgesic, anti-analgesic or no effect of the peptide on thermal ...

journal_title：Neuroscience letters

authors： Mogil JS,Nessim LA,Wilson SG

更新日期：1999-02-19 00:00:00

abstract：:To differentiate the opiate (naloxone) receptor and the enkephalin receptor in rat brain, we solubilized the receptor molecules by detergent and determined the molecular weights by gel filtration. The receptor preparation was bound to [3H] naloxone or [3H] Met5-enkephalin, and was solubilized by Triton X-100. On gel c...

journal_title：Neuroscience letters

authors： Ogawa N,Yamawaki Y,Kuroda H,Nukina I,Ofuji T

更新日期：1981-12-11 00:00:00

abstract：:The long-term potentiation (LTP) was studied using rat hippocampal slices in vitro. LTP in mossy fiber-CA3 pyramidal cell synapses was markedly suppressed in slices prepared from rats which had previously received intraventricular injection of pertussis toxin (PTX), compared with the bovine serum albumin-injected cont...

journal_title：Neuroscience letters

authors： Ito I,Okada D,Sugiyama H

更新日期：1988-07-19 00:00:00

abstract：:The formation of the beta pleated configuration of the amyloid peptide fragment 25-35 in aqueous solution, has been studied using thioflavin-T fluorescence as an indicator of such folding. Both phosphate and adenosine triphosphate (ATP) enhance the formation of aggregated beta-sheets. This phosphate-induced aggregatio...

journal_title：Neuroscience letters

authors： Bondy SC,Truong A

更新日期：1999-05-21 00:00:00