Abstract：
:Embryonic septal neurons were transplanted into the hippocampus of adult rats which had received lateral-ventricular administration of AF64A, a cholinergic neurotoxin, and the effects on hippocampal cholinergic activity were studied. One week after AF64A administration, we injected dissociated septal cell suspension into the dorsal hippocampus, unilaterally. About 3 months after the transplantation, acetylcholine (ACh)-rich septal grafts formed extensive acetylcholinesterase (AChE)-positive fibers into the host hippocampus, recovering choline acetyltransferase (ChAT) level only in the grafted side. These results indicate that septal implants can produce a partial recovery of the cholinergic activity in the chemically damaged hippocampus.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Ikegami S,Nihonmatsu I,Hatanaka H,Takei N,Kawamura Hdoi
10.1016/0304-3940(89)90433-3subject
Has Abstractpub_date
1989-06-05 00:00:00pages
17-22issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(89)90433-3journal_volume
101pub_type
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