Influence of the organic calcium antagonist verapamil on N-methyl-D-aspartate (NMDA) induced cortical field potentials (neocortical slice, guinea pig).

Abstract:

:In the present experiments it was tested whether the organic calcium antagonist verapamil has an influence on N-methyl-D-aspartate (NMDA) induced cortical field potentials (CFP) in neocortical slices of guinea pigs. NMDA (1 mumol/l) was applied via a micropipette by pressure pulses. Verapamil (60 mumol/l) was administered by bath application or ejected locally (100 mumol/l) and simultaneously with NMDA. Neither the systemic administration nor the local application of verapamil had an influence on NMDA induced CFP. It is concluded that the antiepileptic effect of verapamil is not mediated via the NMDA receptor.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Lücke A,Speckmann EJ

doi

10.1016/0304-3940(93)90288-v

subject

Has Abstract

pub_date

1993-10-29 00:00:00

pages

179-82

issue

2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(93)90288-V

journal_volume

161

pub_type

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