Abstract:
:In the present experiments it was tested whether the organic calcium antagonist verapamil has an influence on N-methyl-D-aspartate (NMDA) induced cortical field potentials (CFP) in neocortical slices of guinea pigs. NMDA (1 mumol/l) was applied via a micropipette by pressure pulses. Verapamil (60 mumol/l) was administered by bath application or ejected locally (100 mumol/l) and simultaneously with NMDA. Neither the systemic administration nor the local application of verapamil had an influence on NMDA induced CFP. It is concluded that the antiepileptic effect of verapamil is not mediated via the NMDA receptor.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Lücke A,Speckmann EJdoi
10.1016/0304-3940(93)90288-vsubject
Has Abstractpub_date
1993-10-29 00:00:00pages
179-82issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(93)90288-Vjournal_volume
161pub_type
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2012-08-22 00:00:00
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