Localization of opiate receptors in substantia nigra evidence by lesion studies.

abstract：OBJECTIVE:The role of Glial Fibrillic Acidic Protein (GFAP) as a potential biomarker for relapsing-remitting multiple sclerosis (RRMS) and clinically isolated syndrome (CIS) has been controversially discussed. The aim was to characterize the added value of GFAP levels in the CSF of RRMS and CIS patients in correlation ...

journal_title：Neuroscience letters

authors： Kassubek R,Gorges M,Schocke M,Hagenston VAM,Huss A,Ludolph AC,Kassubek J,Tumani H

更新日期：2017-09-14 00:00:00

abstract：:To elucidate whether high serum lipid peroxidation rates may increase the risk of developing Parkinson's disease (PD), we assessed serum levels of malondialdehyde (MDA), an intermediate in lipid peroxidation processes, in 37 PD patients, with their spouses as the control group. Serum MDA levels did not differ signific...

journal_title：Neuroscience letters

authors： Molina JA,Jiménez-Jiménez FJ,Fernandez-Calle P,Lalinde L,Tenias JM,Pondal M,Vazquez A,Codoceo R

更新日期：1992-03-02 00:00:00

abstract：:The microscopic distribution of omega 3 (peripheral type benzodiazepine) binding sites in sections from normal and ischaemic rat brain has been determined by emulsion autoradiography with the photoaffinity ligand [3H]PK 14105. In the normal rat brain, high densities of omega 3 sites were present in the ependymal cells...

journal_title：Neuroscience letters

authors： Benavides J,Dubois A,Gotti B,Bourdiol F,Scatton B

更新日期：1990-06-22 00:00:00

abstract：:Integrin-associated protein (IAP) is normally localized to the synapse rich plexiform layers of the mammalian retina. In other neuronal systems, IAP and its ligand, P84, have been implicated in synaptic function. Previously, an abnormal distribution of P84 was noted in the IAP-null retina. To examine the potential rol...

journal_title：Neuroscience letters

authors： Ball SL,Lindberg FP,Lagenaur CF,Peachey NS

更新日期：2001-02-02 00:00:00

abstract：:Huntington disease is an uncommon autosomal dominant neurodegenerative disorder caused by expanded polyglutamine repeats in the huntingtin protein. The proximate mechanisms responsible for neurodegeneration are unknown. Copper ions may play a role in Huntington disease by promoting oligomerization of expanded polyglut...

journal_title：Neuroscience letters

authors： Tallaksen-Greene SJ,Janiszewska A,Benton K,Hou G,Dick R,Brewer GJ,Albin RL

更新日期：2009-03-06 00:00:00

abstract：:Approximately 8.5% of the unmyelinated and 2.5% of the myelinated primary afferent axons in lumbar dorsal roots of normal rats are immunostained for glutamate. Thus unmyelinated fibers are the predominantly immunostained population under the conditions of our experiments. The mean size of the unmyelinated fibers is gr...

journal_title：Neuroscience letters

authors： Westlund KN,McNeill DL,Coggeshall RE

更新日期：1989-01-02 00:00:00

abstract：:Experimental findings have suggested the possibility of a functional relationship between the basal ganglia and the hippocampus. Previous research has revealed a predominantly inhibitory action of the caudate nucleus (CN) and an excitatory effect of the globus pallidus (GP) on electrically induced hippocampal afterdis...

journal_title：Neuroscience letters

authors： La Grutta V,Sabatino M,Ferraro G,Liberti G,La Grutta G

更新日期：1986-12-23 00:00:00

abstract：:The cognitive deficits observed in schizophrenia are considered a core feature of the disease. Neuregulin-1 is a risk gene for schizophrenia that is involved in many neurodevelopmental and synaptic plasticity-related processes relevant to schizophrenia. Here, we have utilized a rat model (Nrg1(Tn)), which is hypomorph...

journal_title：Neuroscience letters

authors： Taylor AR,Taylor SB,Koenig JI

更新日期：2012-12-07 00:00:00

abstract：:The prenatal development of axonal connections in the rat olfactory system was studied using DiI. On day 16 (E16), the olfactory and vomeronasal nerves extended from the olfactory epithelia to the olfactory bulb (OB), the terminal nerve to the telencephalic septum, while axons of mitral and tufted cells reached the an...

journal_title：Neuroscience letters

authors： Marchand R,Bélanger MC

更新日期：1991-08-19 00:00:00

abstract：:Recent findings indicated that the excitotoxicity of glutamate analogues was prevented in the mammalian nervous system by N-methyl-D-aspartate (NMDA) antagonists. The neurodegenerative effects of kainic acid, and the putative protection of MK-801 and 6,7-dinitroquinoxaline-2,3-dione (DNQX), were investigated by morpho...

journal_title：Neuroscience letters

authors： Villani L,Carraro S,Guarnieri T

更新日期：1995-06-09 00:00:00

abstract：:In vitro pituitary adenylate cyclase activating polypeptide (PACAP) induces the expression of brain-derived neurotrophic factor (BDNF) via its specific receptor PAC1. Since BDNF has been implicated in learning paradigms and mice lacking functional PAC1 have deficits in hippocampus-dependent associative learning, we in...

journal_title：Neuroscience letters

authors： Zink M,Otto C,Zörner B,Zacher C,Schütz G,Henn FA,Gass P

更新日期：2004-04-22 00:00:00

abstract：:Attention-deficit/hyperactivity disorder (ADHD) is highly prevalent in children and adolescents and both environmental and genetic factors play major roles. Polyunsaturated fatty acids (PUFAs) are postulated to contribute to the development of the infant brain and an imbalance in these may increase the risk of ADHD. I...

journal_title：Neuroscience letters

authors： Bartl J,Walitza S,Grünblatt E

更新日期：2014-01-24 00:00:00

abstract：:The displaced retinal ganglion cells in normal rats and rats with left eye enucleated at birth were studied using the fluorescent dye Fast blue as neuronal marker. The dye was introduced to the right optic tract of the rats 7 days before perfusion. Frozen coronal sections of the brains and retinal whole-mounts from al...

journal_title：Neuroscience letters

authors： Liu ZH,Jen LS

更新日期：1986-06-30 00:00:00

abstract：:Postoperative cognitive dysfunction (POCD) is a common disorder of cognitive functions in aged patients following anesthesia and surgery. α7-nicotinic acetylcholine receptors (α7-nAChR) plays a regulatory role in cognitive processes and is involved in cognitive deficits. This study aims to observe the effect of electr...

journal_title：Neuroscience letters

authors： Liu PR,Zhou Y,Zhang Y,Diao S

更新日期：2017-10-17 00:00:00

abstract：:Physical exercise is beneficial to functional recovery after stroke. But its underling mechanism is still unknown. It is reported that neural stem cells (NSCs) proliferation, migration and differentiation play an important role in recovery following stroke, furthermore, stromal cell derived factor-1α (SDF-1α) and its ...

journal_title：Neuroscience letters

authors： Luo J,Hu X,Zhang L,Li L,Zheng H,Li M,Zhang Q

更新日期：2014-08-22 00:00:00

abstract：:Spontaneous openings of acetylcholine receptor channels were investigated using Xenopus myotomal muscle cells in culture and patch clamp recording methods. Two classes of channels with conductances close to 40 and 60 pS and reversal potentials near 0 mV were found to open in the absence of agonist. The open time of th...

journal_title：Neuroscience letters

authors： Rojas L,Zuazaga C

更新日期：1991-04-01 00:00:00

abstract：:Spinocerebellar ataxia type 2 (SCA2) is associated with an expansion of CAG/polyglutamine-repeat of a gene of unknown function. We performed an immunohistochemical study to identify the immunolocalization of the disease protein ataxin-2 in normal and SCA2 patients. Although normal and expanded ataxin-2 were ubiquitous...

journal_title：Neuroscience letters

authors： Koyano S,Uchihara T,Fujigasaki H,Nakamura A,Yagishita S,Iwabuchi K

更新日期：1999-10-01 00:00:00

abstract：:In order to investigate whether or not nitric oxide (NO) formation underlies the cellular mechanisms of ischemic brain damage, we examined the effects of N omega-nitro-L-arginine (L-NNA), a NO synthase inhibitor, on ischemic brain edema and subsequent infarction in rats with middle cerebral artery occlusion (MCAo). Fo...

journal_title：Neuroscience letters

authors： Nagafuji T,Matsui T,Koide T,Asano T

更新日期：1992-12-07 00:00:00

abstract：:Loss of ovarian function, such as occurs with menopause in human beings and ovariectomy in rodents, results in weight gain. Using multiple-time regression analysis, a sensitive technique for quantifying blood-to-brain transport of peptides and polypeptides, we found that mice ovariectomized for at least 5 weeks had ma...

journal_title：Neuroscience letters

authors： Kastin AJ,Akerstrom V,Maness LM

更新日期：2001-09-07 00:00:00

abstract：:Several studies have shown that blockade of colony stimulating factor-1 (CSF-1) or its receptor (CSF-1R) inhibits disease progression in rodent models of rheumatoid arthritis (RA); however, the role of the CSF-1/CSF-1R pathway in RA-induced pain and functional deficits has not been studied. Thus, we examined the effec...

journal_title：Neuroscience letters

authors： Alvarado-Vazquez PA,Morado-Urbina CE,Castañeda-Corral G,Acosta-Gonzalez RI,Kitaura H,Kimura K,Takano-Yamamoto T,Jiménez-Andrade JM

更新日期：2015-01-01 00:00:00

abstract：AIMS:To test the hypothesis that uridine 5'-triphosphate (UTP) had a protective effect on cerebral ischemia reperfusion (IR) injury in rats. METHODS:Ischemia was induced by intraluminal suture of middle cerebral artery occlusion (MCAO). UTP solution was delivered through an indwelling tail venous catheter via microinf...

journal_title：Neuroscience letters

authors： Tian ML,Zou Z,Yuan HB,Wang CC,Zhu QF,Xu HT,Gao X,Shi XY

更新日期：2009-11-06 00:00:00

abstract：:Dopamine D1 and D2 receptors were studied in putamen of post-mortem brains from controls and patients with Alzheimer-type dementia (ATD). A significant reduction in dopamine D2 receptors was observed in ATD, whereas dopamine D1 receptors were unchanged. Neurochemical markers of striatal acetylcholine and GABA-containi...

journal_title：Neuroscience letters

authors： Cross AJ,Crow TJ,Ferrier IN,Johnson JA,Markakis D

更新日期：1984-11-23 00:00:00

abstract：:In order to test the hypothesis that ethanol (EtOH)-induced changes in growth factor signal transduction contribute to the teratogenic effects of EtOH in the developing brain, neonatal rat pups were administered a single dose of EtOH during the brain growth spurt (5 days of age, PN5). Hippocampal mitogen-activated/ext...

journal_title：Neuroscience letters

authors： Davis MI,Szarowski D,Turner JN,Morrisett RA,Shain W

更新日期：1999-09-10 00:00:00

abstract：:Peptide histidine-isoleucine (PHI) immunoreactivity was located in amacrine-like cells in adult rat retina by use of immunohistochemical techniques. Immunoreactive somata were found in the proximal part of the inner nuclear layer. From these somata, processes could be followed into the inner plexiform layer. The termi...

journal_title：Neuroscience letters

authors： Mikkelsen JD,Larsen JN,Fahrenkrug J,Møller M

更新日期：1987-08-31 00:00:00

abstract：:Pentobarbital anesthesia causes about a 10-fold increase in the antinociceptive potency of beta-endorphin microinjected into the periaqueductal gray (PAG) region of the rat brain. The antinociceptive response to PAG morphine was markedly attenuated during anesthesia, but returned as the rats regained consciousness. As...

journal_title：Neuroscience letters

authors： Smith DJ,Robertson B,Monroe PJ

更新日期：1992-11-09 00:00:00

abstract：:The projections of neurons, in and around the A1 noradrenergic cell group of the caudal ventrolateral medulla (VLM), to nucleus of the solitary tract (NTS) were studied in the cat using the anterograde transport of Phaseolus vulgaris leucoagglutinin (PHA-L). PHA-L was micro-iontophoresed into the region of the A1 nora...

journal_title：Neuroscience letters

authors： Roder S,Ciriello J

更新日期：1992-01-06 00:00:00

abstract：:In vivo rates of incorporation and turnover of palmitate and arachidonate in brain phospholipids were measured in awake rats treated chronically with lithium, following intravenous infusion of radiolabeled palmitate and arachidonate, respectively. Chronic lithium, at a brain level considered to be therapeutic in human...

journal_title：Neuroscience letters

authors： Chang MC,Grange E,Rabin O,Bell JM,Allen DD,Rapoport SI

更新日期：1996-12-20 00:00:00

abstract：:Social isolation has been widely described to induce compulsive aggressive behavior and produce a large decrease of brain serotonin turnover in male mice. The aggressiveness by isolation in mice has been often used as a means for a better understanding of disturbed behavior in human beings. We found that male ICR whit...

journal_title：Neuroscience letters

authors： Miyachi Y,Kasai H,Ohyama H,Yamada T

更新日期：1994-07-04 00:00:00

abstract：:Bilateral injections of the GABA(A) agonist muscimol into the lateral parabrachial nucleus (LPBN) disrupt satiety and induce strong ingestion of water and 0.3M NaCl in fluid-replete rats by mechanisms not completely clear. In the present study, we investigated the effects of the blockade of central muscarinic choliner...

journal_title：Neuroscience letters

authors： Asnar DS,Roncari CF,De Luca LA Jr,de Paula PM,Colombari DS,Menani JV

更新日期：2013-02-08 00:00:00

abstract：:The effect of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), a specific non-N-methyl-D-aspartate (non-NMDA) receptor antagonist, on NMDA-independent epileptiform activity induced by Mg2(+)-free medium was studied in rat basolateral amygdala (BLA) neurons using intracellular recording techniques. Twenty to 30 min after s...

journal_title：Neuroscience letters

authors： Gean PW

更新日期：1990-10-30 00:00:00