Abstract:
:Much research is focused on developing novel drugs to improve memory. In particular, psychostimulants have been shown to enhance memory and have a long history of safe use in humans. In prior work, we have shown that very low doses of amphetamine administered before training on a Pavlovian fear-conditioning task can dramatically facilitate the acquisition of cued fear. The current experiment sought to expand these findings to the extinction of cued fear, a well-known paradigm with therapeutic implications for learned phobias and post-traumatic stress disorder. If extinction reflects new learning, one might expect drugs that enhance the acquisition of cued fear to also enhance the extinction of cued fear. This experiment examined whether 0.005 or 0.05 mg/kg of D-amphetamine (therapeutic doses shown to enhance acquisition) also enhance the extinction of cued fear. Contrary to our hypothesis, amphetamine did not accelerate extinction. Thus, at doses that enhance acquisition of conditioned fear, amphetamine does not appear to enhance extinction.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Carmack SA,Wood SC,Anagnostaras SGdoi
10.1016/j.neulet.2009.10.049subject
Has Abstractpub_date
2010-01-01 00:00:00pages
18-22issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(09)01369-Xjournal_volume
468pub_type
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pub_type: 杂志文章
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