Abstract:
AIM:We performed a study to identify the role of microRNA in thymoma. PATIENTS & METHODS:One hundred twenty-three thymoma patients with clinical information and miRNA expression data from The Cancer Genome Atlas were included in the study. Comprehensive bioinformatics analysis was integrated in our analysis. RESULTS & CONCLUSION:Seven miRNAs were found to be associated with overall survival (p < 0.001). Another four miRNAs were found to be associated with disease-free survival (p < 0.001). Type C thymoma can be distinguished from nontype C thymoma by miRNAs. Interestingly, seven miRNAs showed both prognostic and subtype-specific potential. Our findings suggest that miRNAs can be used for prognostic prediction and subtype stratification.
journal_name
Epigenomicsjournal_title
Epigenomicsauthors
Wei J,Liu Z,Wu K,Yang D,He Y,Chen GG,Zhang J,Lin Jdoi
10.2217/epi-2016-0161subject
Has Abstractpub_date
2017-05-01 00:00:00pages
647-657issue
5eissn
1750-1911issn
1750-192Xjournal_volume
9pub_type
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