Abstract:
:Aim: The role of circRNAs in esophageal squamous cell cancer (ESCC) remains unclear. Materials & methods: Here we profiled six pair plasma circRNA in ESCC based on RNA sequencing, and then verified the elevation of hsa_circ_0004771 in 20 cancer tissues and 105 pair case-control plasma samples by quantitative reverse transcriptase PCR. Results: The upregulation of hsa_circ_0004771 was correlated with heavier tumor burden and poor prognosis, knockdown of it inhibited the ESCC cells proliferation both in vitro and in vivo. Mechanistically, hsa_circ_0004771 positively regulated CDC25A by acting as a molecular sponge of miR-339-5p and rescue assay confirmed this regulatory relationship. Conclusion: These results suggested that hsa_circ_0004771 can serve as a general less-invasive biomarker and may provide diagnostic and prognostic value in carcinoma.
journal_name
Epigenomicsjournal_title
Epigenomicsauthors
Huang E,Fu J,Yu Q,Xie P,Yang Z,Ji H,Wang L,Luo G,Zhang Y,Li Kdoi
10.2217/epi-2019-0404subject
Has Abstractpub_date
2020-04-01 00:00:00pages
587-603issue
7eissn
1750-1911issn
1750-192Xjournal_volume
12pub_type
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