CircRNA hsa_circ_0004771 promotes esophageal squamous cell cancer progression via miR-339-5p/CDC25A axis.


:Aim: The role of circRNAs in esophageal squamous cell cancer (ESCC) remains unclear. Materials & methods: Here we profiled six pair plasma circRNA in ESCC based on RNA sequencing, and then verified the elevation of hsa_circ_0004771 in 20 cancer tissues and 105 pair case-control plasma samples by quantitative reverse transcriptase PCR. Results: The upregulation of hsa_circ_0004771 was correlated with heavier tumor burden and poor prognosis, knockdown of it inhibited the ESCC cells proliferation both in vitro and in vivo. Mechanistically, hsa_circ_0004771 positively regulated CDC25A by acting as a molecular sponge of miR-339-5p and rescue assay confirmed this regulatory relationship. Conclusion: These results suggested that hsa_circ_0004771 can serve as a general less-invasive biomarker and may provide diagnostic and prognostic value in carcinoma.






Huang E,Fu J,Yu Q,Xie P,Yang Z,Ji H,Wang L,Luo G,Zhang Y,Li K




Has Abstract


2020-04-01 00:00:00












  • miRNAs derived from cancer-associated fibroblasts in colorectal cancer.

    abstract::Currently, the incidence of colorectal cancer (CRC) is increasing across the world. The cancer stroma exerts an impact on the spread, invasion and chemoresistance of CRC. The tumor microenvironment involves a complex interaction between cancer cells and stromal cells, for example, cancer-associated fibroblasts (CAFs)....


    pub_type: 杂志文章,评审


    authors: Savardashtaki A,Shabaninejad Z,Movahedpour A,Sahebnasagh R,Mirzaei H,Hamblin MR

    更新日期:2019-11-01 00:00:00

  • Long noncoding RNA: a new contributor and potential therapeutic target in fibrosis.

    abstract::Fibrosis is the excess deposition of extracellular matrix components which occur in multiple organs and ultimately leads to organ failure. Long noncoding RNAs (lncRNAs) are a kind of noncoding RNAs longer than approximately 200 nucleotides with no protein-encoding capacity. A growing body of evidence suggests that lnc...


    pub_type: 杂志文章,评审


    authors: Jiang X,Zhang F

    更新日期:2017-09-01 00:00:00

  • DNA methylation and the hygiene hypothesis: connecting respiratory allergy and childhood acute lymphoblastic leukemia.

    abstract::Aim: The hygiene hypothesis states that a lack of infection in early-life suppresses immune system development, and is linked to respiratory allergy (RA) and childhood acute lymphoblastic leukemia (ALL) risk. Little is known about underlying mechanisms, but DNA methylation is altered in RA and ALL, and in response to ...


    pub_type: 杂志文章


    authors: Langie SA,Timms JA,De Boever P,McKay JA

    更新日期:2019-10-01 00:00:00

  • KDM6B histone demethylase is an epigenetic regulator of estrogen receptor β expression in human pleural mesothelioma.

    abstract:AIM:To assess the correlation between KDM6B and estrogen receptor β (ERβ) expression in malignant pleural mesothelioma (MPM). MATERIALS & METHODS:We evaluated gene expression by in silico analysis of microarray data, real-time PCR and western blot in MPM tumors and cell lines. RESULTS & CONCLUSION:We report a strong ...


    pub_type: 杂志文章


    authors: Manente AG,Pinton G,Zonca S,Tavian D,Habib T,Jithesh PV,Fennell D,Nilsson S,Moro L

    更新日期:2016-09-01 00:00:00

  • Disturbed methylation at multiple imprinted loci: an increasing observation in imprinting disorders.

    abstract::The widely accepted association between aberrant methylation at specific imprinted loci and distinct imprinting disorders has recently been brought into question by the identification of methylation defects at multiple loci (multilocus methylation defect [MLMD]). Strikingly, in different imprinting disorders, the same...


    pub_type: 杂志文章,评审


    authors: Eggermann T,Leisten I,Binder G,Begemann M,Spengler S

    更新日期:2011-10-01 00:00:00

  • MIRA-seq for DNA methylation analysis of CpG islands.

    abstract:AIM:To develop a reliable method for whole genome analysis of DNA methylation. MATERIALS & METHODS:Genome-scale analysis of DNA methylation includes affinity-based approaches such as enrichment using methyl-CpG-binding proteins. One of these methods, the methylated-CpG island recovery assay (MIRA), is based on the hig...


    pub_type: 杂志文章


    authors: Jung M,Kadam S,Xiong W,Rauch TA,Jin SG,Pfeifer GP

    更新日期:2015-08-01 00:00:00

  • Interview with Stephen B Baylin.

    abstract::Stephen B Baylin is a codirector of the Cancer Biology Program at The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and the Virginia and DK Ludwig Professor of Oncology and Medicine. Baylin attended Duke University, where he earned his medical degree and completed his internship and first year residency i...


    pub_type: 面试


    authors: Baylin SB

    更新日期:2015-01-01 00:00:00

  • MiR-377 reverses cancerous phenotypes of pancreatic cells via suppressing DNMT1 and demethylating tumor suppressor genes.

    abstract:AIM:The aim was to investigate the effect of miR-377 on DNMT1 expression and cancer phenotype in pancreatic cancer cells. MATERIALS & METHODS:Real-time PCR, luciferase assay, MTT and Annexin-PI staining were used. RESULTS:Decreased miR-377 and increased DNMT1 (verified as a target for mir-377) levels in pancreatic ca...


    pub_type: 杂志文章


    authors: Azizi M,Fard-Esfahani P,Mahmoodzadeh H,Fazeli MS,Azadmanesh K,Zeinali S,Teimoori-Toolabi L

    更新日期:2017-08-01 00:00:00

  • Maternal obesity is associated with a sex-specific epigenetic programming in human neonatal monocytes.

    abstract::Aim: To determine changes in global DNA methylation in monocytes from neonates of women with obesity, as markers of an immune programming resulting from maternal obesity. Materials & methods: Cord blood monocytes were obtained from neonates born to women with obesity and normal weight, genome-wide differentially methy...


    pub_type: 杂志文章


    authors: Vega-Tapia F,Artigas R,Hernández C,Uauy R,Casanello P,Krause BJ,Castro-Rodriguez JA

    更新日期:2020-11-01 00:00:00

  • Sex-specific histone modifications in mouse fetal and neonatal germ cells.

    abstract:AIMS:Epigenetic signatures of germline cells are dynamically reprogrammed to induce appropriate differentiation, development and sex specification. We investigated sex-specific epigenetic changes in mouse fetal germ cells (FGCs) and neonatal germ cells. MATERIALS & METHODS:Six histone marks in mouse E13.5 FGCs and P1 ...


    pub_type: 杂志文章


    authors: Kawabata Y,Kamio A,Jincho Y,Sakashita A,Takashima T,Kobayashi H,Matsui Y,Kono T

    更新日期:2019-04-01 00:00:00

  • Conference Scene: Epigenetic regulation: from mechanism to intervention.

    abstract::The Medical Research Council Clinical Sciences Centre Symposium on Epigenetic Regulation: From Mechanism to Intervention in London, UK, which was held on 20-22 June 2012, attracted 305 participants from around the globe and included 37 speakers and 85 selected poster presentations. The organizing committee, led by Nia...


    pub_type: 新闻


    authors: Chatterjee A

    更新日期:2012-10-01 00:00:00

  • The relationship between early-life environment, the epigenome and the microbiota.

    abstract::Children exposed to early-life adversity carry a greater risk of poor health and disease into adulthood. This increased disease risk is shadowed by changes in the epigenome. Epigenetics can change gene expression to modify disease risk; unfortunately, how epigenetics are changed by the environment is unclear. It is kn...


    pub_type: 杂志文章,评审


    authors: Majnik AV,Lane RH

    更新日期:2015-10-01 00:00:00

  • A role for microRNAs in the epigenetic control of sexually dimorphic gene expression in the human placenta.

    abstract::Aim: The contribution of miRNAs as epigenetic regulators of sexually dimorphic gene expression in the placenta is unknown. Materials & methods: 382 placentas from the extremely low gestational age newborns (ELGAN) cohort were evaluated for expression levels of 37,268 mRNAs and 2,102 miRNAs using genome-wide RNA-sequen...


    pub_type: 杂志文章


    authors: Eaves LA,Phookphan P,Rager JE,Bangma J,Santos HP Jr,Smeester L,O'Shea TM,Fry RC

    更新日期:2020-09-01 00:00:00

  • Responses of bovine early embryos to S-adenosyl methionine supplementation in culture.

    abstract:AIM:There is a growing concern about the potential adverse effects of high dose folic acid (FA) supplementation before and during pregnancy. FA metabolism generates S-adenosyl methionine (SAM) which is an important cofactor of epigenetic programming. We sought to assess the impact of a large dose of SAM on early embryo...


    pub_type: 杂志文章


    authors: Shojaei Saadi HA,Gagné D,Fournier É,Baldoceda Baldeon LM,Sirard MA,Robert C

    更新日期:2016-08-01 00:00:00

  • Genetic and epigenetic dysregulation of imprinted genes in the brain.

    abstract::Imprinted genes are an epigenetically regulated class of genes that are preferentially expressed from one parental allele. A number of these genes are crucial for placental function and embryonic growth in mice and humans. Disruption of imprinted genes is also associated with several neurodevelopmental disorders, alth...


    pub_type: 杂志文章,评审


    authors: Kernohan KD,Bérubé NG

    更新日期:2010-12-01 00:00:00

  • Epigenomics of idiopathic pulmonary fibrosis.

    abstract::Idiopathic pulmonary fibrosis (IPF) is a complex lung disease of unknown etiology. Development of IPF is influenced by both genetic and environmental factors. Gene-expression profiling studies have taught us quite a bit about the biology of this fatal disease, but epigenetic marks may be the missing link that connects...


    pub_type: 杂志文章,评审


    authors: Yang IV

    更新日期:2012-04-01 00:00:00

  • 5-hydroxymethylcytosine profiling as an indicator of cellular state.

    abstract::DNA methylation is widely studied in the context of cancer. However, the rediscovery of 5-hydroxymethylation of DNA adds a new layer of complexity to understanding the epigenetic basis of development and disease, including carcinogenesis. There have been significant advances in techniques for the detection of 5-hydrox...


    pub_type: 杂志文章,评审


    authors: Laird A,Thomson JP,Harrison DJ,Meehan RR

    更新日期:2013-12-01 00:00:00

  • DNA methylome analysis of acute lymphoblastic leukemia cells reveals stochastic de novo DNA methylation in CpG islands.

    abstract:AIM:To identify regions of aberrant DNA methylation in acute lymphoblastic leukemia (ALL) cells of different subtypes on a genome-wide scale. MATERIALS & METHODS:Whole-genome bisulfite sequencing (WGBS) was used to determine the DNA methylation levels in cells from four pediatric ALL patients of different subtypes. Th...


    pub_type: 杂志文章


    authors: Wahlberg P,Lundmark A,Nordlund J,Busche S,Raine A,Tandre K,Rönnblom L,Sinnett D,Forestier E,Pastinen T,Lönnerholm G,Syvänen AC

    更新日期:2016-10-01 00:00:00

  • Rules governing the mechanism of epigenetic reprogramming memory.

    abstract:AIM:Disclosing the mechanisms that regulate reprogramming memory. MATERIALS & METHODS:We established computational procedure to find DNA methylation somatic memory sites (SMSs) at single CpGs and integrated them with genomics, epigenomics, transcriptomics and imprinting information. RESULTS & CONCLUSION:Reprogramming...


    pub_type: 杂志文章


    authors: Luu PL,Gerovska D,Schöler HR,Araúzo-Bravo MJ

    更新日期:2018-02-01 00:00:00

  • Epigenomic deregulation in the immune system.

    abstract::Proper immune function is the result of multiple cell commitment and differentiation steps, and adequate control of activation mechanisms. Deregulation of transcriptional programs in immune cells leads to the development of hematological malignancies, autoimmune diseases or immunodeficiencies. In this sense, epigeneti...


    pub_type: 杂志文章,评审


    authors: Rodriguez-Cortez VC,Hernando H,de la Rica L,Vento R,Ballestar E

    更新日期:2011-12-01 00:00:00

  • An OMIC biomarker detection algorithm TriVote and its application in methylomic biomarker detection.

    abstract:AIM:Transcriptomic and methylomic patterns represent two major OMIC data sources impacted by both inheritable genetic information and environmental factors, and have been widely used as disease diagnosis and prognosis biomarkers. MATERIALS & METHODS:Modern transcriptomic and methylomic profiling technologies detect th...


    pub_type: 杂志文章


    authors: Xu C,Liu J,Yang W,Shu Y,Wei Z,Zheng W,Feng X,Zhou F

    更新日期:2018-04-01 00:00:00

  • Mutant IDH: a targetable driver of leukemic phenotypes linking metabolism, epigenetics and transcriptional regulation.

    abstract::Aberrant epigenomic programming is a hallmark of acute myeloid leukemia. This is partially due to somatic mutations that perturb cytosine methylation, histone post-translational modifications and transcription factors. Remarkably, mutations in the IDH1 and IDH2 genes perturb the epigenome through all three of these me...


    pub_type: 杂志文章,评审


    authors: Garrett-Bakelman FE,Melnick AM

    更新日期:2016-07-01 00:00:00

  • Role of epigenetics in Alzheimer's and Parkinson's disease.

    abstract::Alzheimer's disease (AD) and Parkinson's disease (PD) are two common neurodegenerative diseases that result in the progressive damage or death of neurons. Environmental agents have the potential to damage the developing and mature nervous system, resulting in neurodegenerative diseases. Heritable changes in gene expre...


    pub_type: 杂志文章,评审


    authors: Kwok JB

    更新日期:2010-10-01 00:00:00

  • DNA methylation consistency implicates the primary tumor cell origin of recurrent hepatocellular carcinoma.

    abstract:AIMS:To investigate if DNA methylation pattern assay could be a new approach to identifying the primary tumor cell origin of the recurrent hepatocellular carcinoma (HCC). MATERIALS & METHODS:Methylation of 24 genes and expression of 22 cancer stem cell (CSC) biomarkers were quantitatively measured in 10 paired primary...


    pub_type: 杂志文章


    authors: Zhang X,Liu S,Shen C,Wu Y,Zhang L,Chen X,Lu F

    更新日期:2015-01-01 00:00:00

  • Identification of lncRNA-associated ceRNA network in high-grade serous ovarian cancer metastasis.

    abstract::Aim: To uncover a novel lncRNA-miRNA-mRNA network associated with high-grade serous ovarian cancer metastasis. Material & methods: The candidate differentially expressed lncRNAs were obtained from RNA-sequencing data and determined by functional experiments. The downstream miRNAs and mRNAs were identified by bioinform...


    pub_type: 杂志文章


    authors: Li X,Yu S,Yang R,Wang Q,Liu X,Ma M,Li Y,Wu S

    更新日期:2020-07-01 00:00:00

  • Epigenetics of kidney cancer and bladder cancer.

    abstract::This article focuses on the epigenetic alterations of aberrant promoter hypermethylation of genes, and histone modifications or RNA interference in cancer cells. Current knowledge of the hypermethylation of allele(s) in classical tumor suppressor genes in inherited and sporadic cancer, candidate tumor suppressor and o...


    pub_type: 杂志文章,评审


    authors: Hoffman AM,Cairns P

    更新日期:2011-02-01 00:00:00

  • LncRNA HORAS5 promotes taxane resistance in castration-resistant prostate cancer via a BCL2A1-dependent mechanism.

    abstract::Background: Castration-resistant prostate cancer (CRPC) is an incurable malignancy. Long noncoding RNAs (lncRNAs) play key roles in drug resistance. Materials & methods: LncRNA HORAS5 role in cabazitaxel resistance (i.e., cell-count, IC50 and caspase activity) was studied via lentiviral-mediated overexpression and siR...


    pub_type: 杂志文章


    authors: Pucci P,Venalainen E,Alborelli I,Quagliata L,Hawkes C,Mather R,Romero I,Rigas SH,Wang Y,Crea F

    更新日期:2020-07-01 00:00:00

  • Dynamic analysis of m6A methylation spectroscopy during progression and reversal of hepatic fibrosis.

    abstract::Aim: To dynamically analyze the differential m6A methylation during the progression and reversal of hepatic fibrosis. Materials & methods: We induced hepatic fibrosis in C57/BL6 mice by intraperitoneal injection of CCl4. The reversal model of hepatic fibrosis was established by stopping drug after continuous injection...


    pub_type: 杂志文章


    authors: Cui Z,Huang N,Liu L,Li X,Li G,Chen Y,Wu Q,Zhang J,Long S,Wang M,Sun F,Shi Y,Pan Q

    更新日期:2020-10-01 00:00:00

  • Epigenetic role of miRNAs in normal and leukemic hematopoiesis.

    abstract::Hematopoiesis is a regulated multistep process, whereby transcriptional and epigenetic events contribute to progenitor fate determination. miRNAs have emerged as key players in hematopoietic cell development, differentiation and malignant transformation. From embryonic development through to adult life, miRNAs coopera...


    pub_type: 杂志文章


    authors: Pagano F,De Marinis E,Grignani F,Nervi C

    更新日期:2013-01-01 00:00:00

  • Comprehensive mapping of the methylation landscape of 16 CpG-dense regions in oral and pharyngeal squamous cell carcinoma.

    abstract::Aim: The goal of this study was to comprehensively interrogate and map DNA methylation across 16 CpG-dense regions previously associated with oral and pharyngeal squamous cell carcinoma (OPSCC). Materials & methods: Targeted multiplex bisulfite amplicon sequencing was performed on four OPSCC cell lines and primary non...


    pub_type: 杂志文章


    authors: Langevin SM,Kuhnell D,Niu L,Biesiada J,Leung YK,Deka R,Chen A,Medvedovic M,Kelsey KT,Kasper S,Zhang X

    更新日期:2019-07-01 00:00:00