CircRNA hsa_circ_0004771 promotes esophageal squamous cell cancer progression via miR-339-5p/CDC25A axis.

Abstract:

:Aim: The role of circRNAs in esophageal squamous cell cancer (ESCC) remains unclear. Materials & methods: Here we profiled six pair plasma circRNA in ESCC based on RNA sequencing, and then verified the elevation of hsa_circ_0004771 in 20 cancer tissues and 105 pair case-control plasma samples by quantitative reverse transcriptase PCR. Results: The upregulation of hsa_circ_0004771 was correlated with heavier tumor burden and poor prognosis, knockdown of it inhibited the ESCC cells proliferation both in vitro and in vivo. Mechanistically, hsa_circ_0004771 positively regulated CDC25A by acting as a molecular sponge of miR-339-5p and rescue assay confirmed this regulatory relationship. Conclusion: These results suggested that hsa_circ_0004771 can serve as a general less-invasive biomarker and may provide diagnostic and prognostic value in carcinoma.

journal_name

Epigenomics

journal_title

Epigenomics

authors

Huang E,Fu J,Yu Q,Xie P,Yang Z,Ji H,Wang L,Luo G,Zhang Y,Li K

doi

10.2217/epi-2019-0404

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

587-603

issue

7

eissn

1750-1911

issn

1750-192X

journal_volume

12

pub_type

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