解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Aim: This study aims to examine the DNA methylation (DNAm) and expression patterns of genes associated with placental angiogenesis in preeclampsia. Materials & methods: DNAm and expression were examined in normotensive (n = 100) and preeclampsia (n = 100) women using pyrosequencing and quantitative real-time PCR respe...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2020-0318
更新日期:2021-01-20 00:00:00
abstract::Aim: This study aimed to identify novel miRNAs (miRs) as regulators of UGT1A gene expression and to evaluate them as potential risk factors for the development of liver fibrosis/cirrhosis. Materials & methods: miRNA target sites in UDP-glucuronosyltransferase 1A (UGT1A) 3'-UTR were predicted and confirmed by luciferas...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2020-0244
更新日期:2021-01-12 00:00:00
abstract::Aim: To assess isorhamnetin efficacy for diabetic kidney disease in a Type 2 diabetes mellitus rat model, through investigating its effect at the epigenetic, mRNA and protein levels. Materials & methods: Type 2 diabetes mellitus was induced in rats by streptozotocin and high-fat diet. Rats were treated with isorhamnet...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2020-0353
更新日期:2021-01-07 00:00:00
abstract::This study aimed to unveil the functional roles of LINC00221 in hepatocellular carcinoma (HCC). A discovery cohort and a validation cohort were respectively used to identify and verify the clinical value of LINC00221 in HCC. Bioinformatics analysis was performed to explore its potential mechanisms. LINC00221 was upreg...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2020-0363
更新日期:2021-01-07 00:00:00
abstract::Aim: To develop a method for estimating cell-specific effects in epigenomic association studies in the presence of cell type heterogeneity. Materials & methods: We utilized Monte Carlo Expectation-Maximization (MCEM) algorithm with Metropolis-Hastings sampler to reconstruct the 'missing' cell-specific methylations and...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2020-0147
更新日期:2020-12-22 00:00:00
abstract::Neuromuscular disorders are a heterogeneous group of conditions affecting the neuromuscular system. The aim of this article is to review the major epigenetic findings in motor neuron diseases and major hereditary muscular dystrophies. DNA methylation changes are observed in both hereditary and sporadic forms, and comb...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2020-0282
更新日期:2020-12-01 00:00:00
abstract::Aim: Myotonic dystrophy type 1 (DM1) is caused by an unstable trinucleotide (CTG) expansion at the DMPK gene locus. Cognitive dysfunctions are often observed in the condition. We investigated the association between DMPK blood DNA methylation (DNAm) and cognitive functions in DM1, considering expansion length and vari...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2020-0328
更新日期:2020-12-01 00:00:00
abstract::Aim: To determine changes in global DNA methylation in monocytes from neonates of women with obesity, as markers of an immune programming resulting from maternal obesity. Materials & methods: Cord blood monocytes were obtained from neonates born to women with obesity and normal weight, genome-wide differentially methy...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2020-0098
更新日期:2020-11-01 00:00:00
abstract::Aim: To identify lncRNAs targeting GSK3β in MDD. Materials & methods: The levels of GSK3β and its three targeting lncRNAs (gsk3β antisense AS1, AS2 and AS3) were detected in 52 patients with major depressive disorder (MDD) before and after 8 weeks of escitalopram treatment. The functional study was evaluated using the...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2019-0402
更新日期:2020-10-01 00:00:00
abstract::Aim: To dynamically analyze the differential m6A methylation during the progression and reversal of hepatic fibrosis. Materials & methods: We induced hepatic fibrosis in C57/BL6 mice by intraperitoneal injection of CCl4. The reversal model of hepatic fibrosis was established by stopping drug after continuous injection...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2019-0365
更新日期:2020-10-01 00:00:00
abstract::Aim: The contribution of miRNAs as epigenetic regulators of sexually dimorphic gene expression in the placenta is unknown. Materials & methods: 382 placentas from the extremely low gestational age newborns (ELGAN) cohort were evaluated for expression levels of 37,268 mRNAs and 2,102 miRNAs using genome-wide RNA-sequen...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2020-0062
更新日期:2020-09-01 00:00:00
abstract::Aim: We examined methylation changes in cell-free DNA (cfDNA) in metastatic castration-resistant prostate cancer (mCRPC) during treatment. Patients & methods: Genome-wide methylation analysis of sequentially collected cfDNA samples derived from mCRPC patients undergoing androgen-targeting therapy was performed. Result...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2020-0173
更新日期:2020-08-01 00:00:00
abstract::Background: Castration-resistant prostate cancer (CRPC) is an incurable malignancy. Long noncoding RNAs (lncRNAs) play key roles in drug resistance. Materials & methods: LncRNA HORAS5 role in cabazitaxel resistance (i.e., cell-count, IC50 and caspase activity) was studied via lentiviral-mediated overexpression and siR...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2019-0316
更新日期:2020-07-01 00:00:00
abstract::Aim: To uncover a novel lncRNA-miRNA-mRNA network associated with high-grade serous ovarian cancer metastasis. Material & methods: The candidate differentially expressed lncRNAs were obtained from RNA-sequencing data and determined by functional experiments. The downstream miRNAs and mRNAs were identified by bioinform...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2020-0097
更新日期:2020-07-01 00:00:00
abstract::Aim: To identify pregnancy-associated changes in cervical noncoding RNA (ncRNA), including miRNA and long noncoding RNA (lncRNA), and their potential effects on biologic processes. Materials & methods: We enrolled 21 pregnant women with term deliveries (≥37 weeks' gestation) in a prospective cohort and collected cervi...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2019-0231
更新日期:2020-06-01 00:00:00
abstract::Sepsis is a life-threatening condition that occurs when the body responds to an infection damaging its own tissues. Sepsis survivors sometimes suffer from immunosuppression increasing the risk of death. To our best knowledge, there is no 'gold standard' for defining immunosuppression except for a composite clinical en...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2019-0329
更新日期:2020-04-01 00:00:00
abstract::Aim: The role of circRNAs in esophageal squamous cell cancer (ESCC) remains unclear. Materials & methods: Here we profiled six pair plasma circRNA in ESCC based on RNA sequencing, and then verified the elevation of hsa_circ_0004771 in 20 cancer tissues and 105 pair case-control plasma samples by quantitative reverse t...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2019-0404
更新日期:2020-04-01 00:00:00
abstract::Aim: We aimed to explore the roles of noncoding RNAs (ncRNAs) in renal cell carcinoma. Materials & methods: The altered expressions of miR-196a2, miR-499a, H19, MALAT1 and GAS5, as well as some target transcripts were identified by quantitative real-time reverse transcription polymerase chain reaction. Results: Up-reg...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2019-0120
更新日期:2020-02-01 00:00:00
abstract::Cancer numbers increasing, cases heterogeneity and the drug resistance emergence have pushed scientists to search for innovative solutions for patients and epimutations can be one. Methylated DNA, modified nucleosomes and noncoding RNAs are found in all cells, including tumor cells. They are intracellular actors but a...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2019-0170
更新日期:2020-01-01 00:00:00
abstract::Until recently, drug development in oncology was focused on treating most patients for a specific cancer type without taking in account the heterogeneity between these patients in term of response to treatment. Therefore, this type of broad treatment approach excludes the treatment of patient not responding to disease...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2019-0169
更新日期:2020-01-01 00:00:00
abstract::Currently, the incidence of colorectal cancer (CRC) is increasing across the world. The cancer stroma exerts an impact on the spread, invasion and chemoresistance of CRC. The tumor microenvironment involves a complex interaction between cancer cells and stromal cells, for example, cancer-associated fibroblasts (CAFs)....
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi-2019-0110
更新日期:2019-11-01 00:00:00
abstract::Aim: The hygiene hypothesis states that a lack of infection in early-life suppresses immune system development, and is linked to respiratory allergy (RA) and childhood acute lymphoblastic leukemia (ALL) risk. Little is known about underlying mechanisms, but DNA methylation is altered in RA and ALL, and in response to ...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2019-0052
更新日期:2019-10-01 00:00:00
abstract::Aim: The goal of this study was to comprehensively interrogate and map DNA methylation across 16 CpG-dense regions previously associated with oral and pharyngeal squamous cell carcinoma (OPSCC). Materials & methods: Targeted multiplex bisulfite amplicon sequencing was performed on four OPSCC cell lines and primary non...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2018-0172
更新日期:2019-07-01 00:00:00
abstract::Aim: To examine the impact of 4-nonylphenol (4-NP), on the expression of polycomb repressive complexes and cellular proliferation. Materials & methods: Cell proliferation assays, quantitative PCR, Western blotting, luciferase reporter assay, chromatin immunoprecipitation-quantitative PCR were used for the study. Resul...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2018-0175
更新日期:2019-06-01 00:00:00
abstract::Aim: Epilepsy is a common neurological disorder characterized by recurrent seizures. We performed epigenetic analyses between and within 15 monozygotic (MZ) twin pairs discordant for focal or generalized epilepsy. Methods: DNA methylation analysis was performed using Illumina Infinium MethylationEPIC arrays, in blood ...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2018-0136
更新日期:2019-06-01 00:00:00
abstract:AIMS:Epigenetic signatures of germline cells are dynamically reprogrammed to induce appropriate differentiation, development and sex specification. We investigated sex-specific epigenetic changes in mouse fetal germ cells (FGCs) and neonatal germ cells. MATERIALS & METHODS:Six histone marks in mouse E13.5 FGCs and P1 ...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2018-0193
更新日期:2019-04-01 00:00:00
abstract::Histone modifications regulate the structural status of chromatin and thereby influence the transcriptional status of genes. These processes are controlled by the recruitment of different enzymes to a specific genomic site. Furthermore, obtaining an understanding of these mechanisms could help delineate alternative tr...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi-2018-0081
更新日期:2019-02-01 00:00:00
abstract:AIM:We examined maternal prepregnancy anthropometry and cord blood DNA methylation. METHODS:Associations between maternal measures (i.e., weight, height, waist circumference, hip circumference, skinfolds, leptin) and methylation β-values at each CpG (measured by the Infinium MethylationEPIC BeadChip) were estimated am...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2018-0099
更新日期:2019-02-01 00:00:00
abstract:AIM:To identify DNA methylation biomarkers in peripheral blood samples from triple-negative breast cancer (TNBC) patients. MATERIALS & METHODS:We conducted an epigenome-wide association study (EWAS): the most promising markers were identified in 233 TNBC case-control pairs (discovery set) and subsequently validated in...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2018-0121
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To study DNA methylation patterns of cortical pyramidal layers susceptible to late-onset Alzheimer's disease (LOAD) neurodegeneration. METHODS:Laser-assisted microdissection to select pyramidal layers' cells in frontal cortex of 32 human brains (18 LOAD) and Infinium DNA Methylation 450K analysis were perfor...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2017-0160
更新日期:2018-11-01 00:00:00
abstract:AIM:Imprinted genes exhibit expression in a parent-of-origin-dependent manner and are critical for child development. Recent limited evidence suggests that prenatal exposure to phthalates, ubiquitous endocrine disruptors, can affect their epigenetic dysregulation. MATERIALS & METHODS:We quantified DNA methylation of n...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2017-0178
更新日期:2018-07-01 00:00:00
abstract:AIM:Transcriptomic and methylomic patterns represent two major OMIC data sources impacted by both inheritable genetic information and environmental factors, and have been widely used as disease diagnosis and prognosis biomarkers. MATERIALS & METHODS:Modern transcriptomic and methylomic profiling technologies detect th...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2017-0097
更新日期:2018-04-01 00:00:00
abstract:AIM:To investigate epigenomic changes in pregnancy and early postpartum in women with and without type 2 diabetes. METHODS:Dimethylation of histones H3K4, H3K9, H3K27, H3K36 and H3K79 was measured in white blood cells of women at 30 weeks pregnancy, at 8-10 and 20 weeks postpartum and in never-pregnant women. RESULTS...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2017-0129
更新日期:2018-04-01 00:00:00
abstract:AIM:This study aims to couple DNA methylation changes and evolution of retrogenes. MATERIALS & METHODS:A new two-step strategy was developed to screen retrogenes. Further, reduced representation bisulfite sequencing and RNA-seq data of eight tissues were used to analyze retrogenes. RESULTS:A total of 964 retrocopies ...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2017-0071
更新日期:2018-02-01 00:00:00
abstract:AIM:Disclosing the mechanisms that regulate reprogramming memory. MATERIALS & METHODS:We established computational procedure to find DNA methylation somatic memory sites (SMSs) at single CpGs and integrated them with genomics, epigenomics, transcriptomics and imprinting information. RESULTS & CONCLUSION:Reprogramming...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2017-0098
更新日期:2018-02-01 00:00:00
abstract:AIM:To show that an increased correlation between CpGs after selection through an epigenome-wide association studies (EWAS) might translate into biased replication results. METHODS:Pairwise correlation coefficients between CpGs selected in two published EWAS, the top hits replication, Bonferroni p-values, Benjamini-Ho...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2017-0073
更新日期:2017-12-01 00:00:00
abstract::Fibrosis is the excess deposition of extracellular matrix components which occur in multiple organs and ultimately leads to organ failure. Long noncoding RNAs (lncRNAs) are a kind of noncoding RNAs longer than approximately 200 nucleotides with no protein-encoding capacity. A growing body of evidence suggests that lnc...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi-2017-0020
更新日期:2017-09-01 00:00:00
abstract:AIM:The aim was to investigate the effect of miR-377 on DNMT1 expression and cancer phenotype in pancreatic cancer cells. MATERIALS & METHODS:Real-time PCR, luciferase assay, MTT and Annexin-PI staining were used. RESULTS:Decreased miR-377 and increased DNMT1 (verified as a target for mir-377) levels in pancreatic ca...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2016-0175
更新日期:2017-08-01 00:00:00
abstract:AIM:To identify differentially methylated probes (DMPs) and regions (DMRs) in relation to chronic obstructive pulmonary disease (COPD) and lung function traits. METHODS:We performed an epigenome-wide association study of COPD and spirometric parameters, including forced expiratory volume in 1 s (FEV1), forced vital ca...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2017-0002
更新日期:2017-07-01 00:00:00
abstract:AIM:We performed a study to identify the role of microRNA in thymoma. PATIENTS & METHODS:One hundred twenty-three thymoma patients with clinical information and miRNA expression data from The Cancer Genome Atlas were included in the study. Comprehensive bioinformatics analysis was integrated in our analysis. RESULTS ...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2016-0161
更新日期:2017-05-01 00:00:00