Abstract:
:Idiopathic pulmonary fibrosis (IPF) is a complex lung disease of unknown etiology. Development of IPF is influenced by both genetic and environmental factors. Gene-expression profiling studies have taught us quite a bit about the biology of this fatal disease, but epigenetic marks may be the missing link that connects the environmental exposure in genetically predisposed individuals to transcriptome changes associated with the development of IPF. This review will begin with an introduction to the disease, followed by brief summaries of studies of gene expression in IPF and epigenetic marks associated with exposures relevant to IPF. The majority of the discussion will focus on epigenetic studies conducted so far in IPF, the limitations, challenges nd future directions in this field.
journal_name
Epigenomicsjournal_title
Epigenomicsauthors
Yang IVdoi
10.2217/epi.12.10subject
Has Abstractpub_date
2012-04-01 00:00:00pages
195-203issue
2eissn
1750-1911issn
1750-192Xjournal_volume
4pub_type
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