miRNAs derived from cancer-associated fibroblasts in colorectal cancer.

abstract：:Protein methyltransferases (PMT)s play essential roles in many biological processes through methylation of histones and diverse nonhistone substrates. Dysregulation of these enzymes has been implicated in many diseases including cancers. While PMT-associated biology can be probed via genetic perturbation, this approac...

journal_title：Epigenomics

authors： Luo M

更新日期：2015-01-01 00:00:00

abstract：:Aim: The hygiene hypothesis states that a lack of infection in early-life suppresses immune system development, and is linked to respiratory allergy (RA) and childhood acute lymphoblastic leukemia (ALL) risk. Little is known about underlying mechanisms, but DNA methylation is altered in RA and ALL, and in response to ...

journal_title：Epigenomics

authors： Langie SA,Timms JA,De Boever P,McKay JA

更新日期：2019-10-01 00:00:00

abstract：:Stephen B Baylin is a codirector of the Cancer Biology Program at The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and the Virginia and DK Ludwig Professor of Oncology and Medicine. Baylin attended Duke University, where he earned his medical degree and completed his internship and first year residency i...

journal_title：Epigenomics

authors： Baylin SB

更新日期：2015-01-01 00:00:00

abstract：AIM:Transcriptomic and methylomic patterns represent two major OMIC data sources impacted by both inheritable genetic information and environmental factors, and have been widely used as disease diagnosis and prognosis biomarkers. MATERIALS & METHODS:Modern transcriptomic and methylomic profiling technologies detect th...

journal_title：Epigenomics

authors： Xu C,Liu J,Yang W,Shu Y,Wei Z,Zheng W,Feng X,Zhou F

更新日期：2018-04-01 00:00:00

abstract：:Epigenetic enzymes are emerging as crucial controllers of macrophages, innate immune cells that determine the outcome of many inflammatory diseases. Recent studies demonstrate that the activity of particular chromatin-modifying enzymes is regulated by the availability of specific metabolites like acetyl-coenzyme A, S-...

journal_title：Epigenomics

authors： Baardman J,Licht I,de Winther MP,Van den Bossche J

更新日期：2015-10-01 00:00:00

abstract：:Aim: Myotonic dystrophy type 1 (DM1) is caused by an unstable trinucleotide (CTG) expansion at the DMPK gene locus. Cognitive dysfunctions are often observed in the condition. We investigated the association between DMPK blood DNA methylation (DNAm) and cognitive functions in DM1, considering expansion length and vari...

journal_title：Epigenomics

authors： Breton É,Légaré C,Overend G,Guay SP,Monckton D,Mathieu J,Gagnon C,Richer L,Gallais B,Bouchard L

更新日期：2020-12-01 00:00:00

abstract：AIM:The isoflavones genistein, daidzein and equol (daidzein metabolite) have been reported to interact with epigenetic modifications, specifically hypermethylation of tumor suppressor genes. The objective of this study was to analyze and understand the mechanisms by which phytoestrogens act on chromatin in breast cance...

journal_title：Epigenomics

authors： Dagdemir A,Durif J,Ngollo M,Bignon YJ,Bernard-Gallon D

更新日期：2013-02-01 00:00:00

abstract：AIM:To assess the associations between gestational diabetes mellitus (GDM) and DNA methylation levels at genes related to energy metabolism. PATIENTS & METHODS:Ten loci were selected from our recent epigenome-wide association study on GDM. DNA methylation levels were quantified by bisulfite pyrosequencing in 80 placen...

journal_title：Epigenomics

authors： Houde AA,Ruchat SM,Allard C,Baillargeon JP,St-Pierre J,Perron P,Gaudet D,Brisson D,Hivert MF,Bouchard L

更新日期：2015-10-01 00:00:00

abstract：AIM:To investigate epigenomic changes in pregnancy and early postpartum in women with and without type 2 diabetes. METHODS:Dimethylation of histones H3K4, H3K9, H3K27, H3K36 and H3K79 was measured in white blood cells of women at 30 weeks pregnancy, at 8-10 and 20 weeks postpartum and in never-pregnant women. RESULTS...

journal_title：Epigenomics

authors： Michalczyk AA,Janus ED,Judge A,Ebeling PR,Best JD,Ackland MJ,Asproloupos D,Dunbar JA,Ackland ML

更新日期：2018-04-01 00:00:00

abstract：:Histone modifications regulate the structural status of chromatin and thereby influence the transcriptional status of genes. These processes are controlled by the recruitment of different enzymes to a specific genomic site. Furthermore, obtaining an understanding of these mechanisms could help delineate alternative tr...

journal_title：Epigenomics

authors： Calcagno DQ,Wisnieski F,Mota ERDS,Maia de Sousa SB,Costa da Silva JM,Leal MF,Gigek CO,Santos LC,Rasmussen LT,Assumpção PP,Burbano RR,Smith MA

更新日期：2019-02-01 00:00:00

abstract：:Asthma is a chronic disease which causes recurrent breathlessness affecting 300 million people worldwide of whom 250,000 die annually. The epigenome is a set of heritable modifications and tags that affect the genome without changing the intrinsic DNA sequence. These marks include DNA methylation, modifications to his...

journal_title：Epigenomics

authors： Brook PO,Perry MM,Adcock IM,Durham AL

更新日期：2015-01-01 00:00:00

abstract：:Imprinted genes are an epigenetically regulated class of genes that are preferentially expressed from one parental allele. A number of these genes are crucial for placental function and embryonic growth in mice and humans. Disruption of imprinted genes is also associated with several neurodevelopmental disorders, alth...

journal_title：Epigenomics

authors： Kernohan KD,Bérubé NG

更新日期：2010-12-01 00:00:00

abstract：:Aim: This study aimed to identify novel miRNAs (miRs) as regulators of UGT1A gene expression and to evaluate them as potential risk factors for the development of liver fibrosis/cirrhosis. Materials & methods: miRNA target sites in UDP-glucuronosyltransferase 1A (UGT1A) 3'-UTR were predicted and confirmed by luciferas...

journal_title：Epigenomics

authors： Paulusch S,Kalthoff S,Landerer S,Jansen C,Schierwagen R,Klein S,Trebicka J,Strassburg CP

更新日期：2021-01-12 00:00:00

abstract：OBJECTIVE:To study DNA methylation patterns of cortical pyramidal layers susceptible to late-onset Alzheimer's disease (LOAD) neurodegeneration. METHODS:Laser-assisted microdissection to select pyramidal layers' cells in frontal cortex of 32 human brains (18 LOAD) and Infinium DNA Methylation 450K analysis were perfor...

journal_title：Epigenomics

authors： Hernández HG,Sandoval-Hernández AG,Garrido-Gil P,Labandeira-Garcia JL,Zelaya MV,Bayon GF,Fernández AF,Fraga MF,Arboleda G,Arboleda H

更新日期：2018-11-01 00:00:00

abstract：:Fibrosis is the excess deposition of extracellular matrix components which occur in multiple organs and ultimately leads to organ failure. Long noncoding RNAs (lncRNAs) are a kind of noncoding RNAs longer than approximately 200 nucleotides with no protein-encoding capacity. A growing body of evidence suggests that lnc...

journal_title：Epigenomics

authors： Jiang X,Zhang F

更新日期：2017-09-01 00:00:00

abstract：AIM:To assess the correlation between KDM6B and estrogen receptor β (ERβ) expression in malignant pleural mesothelioma (MPM). MATERIALS & METHODS:We evaluated gene expression by in silico analysis of microarray data, real-time PCR and western blot in MPM tumors and cell lines. RESULTS & CONCLUSION:We report a strong ...

journal_title：Epigenomics

authors： Manente AG,Pinton G,Zonca S,Tavian D,Habib T,Jithesh PV,Fennell D,Nilsson S,Moro L

更新日期：2016-09-01 00:00:00

abstract：:Arsenic is a nonmutagenic human carcinogen that induces tumors through unknown mechanisms. A growing body of evidence suggests that its carcinogenicity results from epigenetic changes, particularly in DNA methylation. Changes in gene methylation status, mediated by arsenic, have been proposed to activate oncogene expr...

journal_title：Epigenomics

authors： Reichard JF,Puga A

更新日期：2010-02-01 00:00:00

abstract：AIM:To identify regions of aberrant DNA methylation in acute lymphoblastic leukemia (ALL) cells of different subtypes on a genome-wide scale. MATERIALS & METHODS:Whole-genome bisulfite sequencing (WGBS) was used to determine the DNA methylation levels in cells from four pediatric ALL patients of different subtypes. Th...

journal_title：Epigenomics

authors： Wahlberg P,Lundmark A,Nordlund J,Busche S,Raine A,Tandre K,Rönnblom L,Sinnett D,Forestier E,Pastinen T,Lönnerholm G,Syvänen AC

更新日期：2016-10-01 00:00:00

abstract：:Fundamental aspects of mammalian brain evolution occurred in the context of viviparity and placentation brought about by the epigenetic regulation of imprinted genes. Since the fetal placenta hormonally primes the maternal brain, two genomes in one individual are transgenerationally co-adapted to ensure maternal care ...

journal_title：Epigenomics

authors： Keverne EB

更新日期：2011-04-01 00:00:00

abstract：:This study aimed to unveil the functional roles of LINC00221 in hepatocellular carcinoma (HCC). A discovery cohort and a validation cohort were respectively used to identify and verify the clinical value of LINC00221 in HCC. Bioinformatics analysis was performed to explore its potential mechanisms. LINC00221 was upreg...

journal_title：Epigenomics

authors： Feng Y,Dramani Maman ST,Zhu X,Liu X,Bongolo CC,Liang C,Tu J

更新日期：2021-01-07 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a complex lung disease of unknown etiology. Development of IPF is influenced by both genetic and environmental factors. Gene-expression profiling studies have taught us quite a bit about the biology of this fatal disease, but epigenetic marks may be the missing link that connects...

journal_title：Epigenomics

authors： Yang IV

更新日期：2012-04-01 00:00:00

abstract：:DNA methylation is widely studied in the context of cancer. However, the rediscovery of 5-hydroxymethylation of DNA adds a new layer of complexity to understanding the epigenetic basis of development and disease, including carcinogenesis. There have been significant advances in techniques for the detection of 5-hydrox...

journal_title：Epigenomics

authors： Laird A,Thomson JP,Harrison DJ,Meehan RR

更新日期：2013-12-01 00:00:00

abstract：:The ability to culture pluripotent stem cells and direct their differentiation into specific cell types in vitro provides a valuable experimental system for modeling pluripotency, development and cellular differentiation. High-throughput profiling of the transcriptomes and epigenomes of pluripotent stem cells and thei...

journal_title：Epigenomics

authors： Thiagarajan RD,Morey R,Laurent LC

更新日期：2014-02-01 00:00:00

abstract：:Aim: To determine changes in global DNA methylation in monocytes from neonates of women with obesity, as markers of an immune programming resulting from maternal obesity. Materials & methods: Cord blood monocytes were obtained from neonates born to women with obesity and normal weight, genome-wide differentially methy...

journal_title：Epigenomics

authors： Vega-Tapia F,Artigas R,Hernández C,Uauy R,Casanello P,Krause BJ,Castro-Rodriguez JA

更新日期：2020-11-01 00:00:00

abstract：:Cancer numbers increasing, cases heterogeneity and the drug resistance emergence have pushed scientists to search for innovative solutions for patients and epimutations can be one. Methylated DNA, modified nucleosomes and noncoding RNAs are found in all cells, including tumor cells. They are intracellular actors but a...

journal_title：Epigenomics

authors： Duforestel M,Briand J,Bougras-Cartron G,Heymann D,Frenel JS,Vallette FM,Cartron PF

更新日期：2020-01-01 00:00:00

abstract：AIM:Imprinted genes exhibit expression in a parent-of-origin-dependent manner and are critical for child development. Recent limited evidence suggests that prenatal exposure to phthalates, ubiquitous endocrine disruptors, can affect their epigenetic dysregulation. MATERIALS & METHODS:We quantified DNA methylation of n...

journal_title：Epigenomics

authors： Tindula G,Murphy SK,Grenier C,Huang Z,Huen K,Escudero-Fung M,Bradman A,Eskenazi B,Hoyo C,Holland N

更新日期：2018-07-01 00:00:00

abstract：:Aim: To assess isorhamnetin efficacy for diabetic kidney disease in a Type 2 diabetes mellitus rat model, through investigating its effect at the epigenetic, mRNA and protein levels. Materials & methods: Type 2 diabetes mellitus was induced in rats by streptozotocin and high-fat diet. Rats were treated with isorhamnet...

journal_title：Epigenomics

authors： Matboli M,Ibrahim D,Hasanin AH,Hassan MK,Habib EK,Bekhet MM,Afifi AM,Eissa S

更新日期：2021-01-07 00:00:00

abstract：AIMS:Epigenetic signatures of germline cells are dynamically reprogrammed to induce appropriate differentiation, development and sex specification. We investigated sex-specific epigenetic changes in mouse fetal germ cells (FGCs) and neonatal germ cells. MATERIALS & METHODS:Six histone marks in mouse E13.5 FGCs and P1 ...

journal_title：Epigenomics

authors： Kawabata Y,Kamio A,Jincho Y,Sakashita A,Takashima T,Kobayashi H,Matsui Y,Kono T

更新日期：2019-04-01 00:00:00

abstract：:The E3 ubiquitin ligase UBE3A, also known as E6-AP, has a multitude of ascribed functions and targets relevant to human health and disease. Epigenetic regulation of the UBE3A gene by parentally imprinted noncoding transcription within human chromosome 15q11.2-q13.3 is responsible for the maternal-specific effects of 1...

journal_title：Epigenomics

authors： LaSalle JM,Reiter LT,Chamberlain SJ

更新日期：2015-10-01 00:00:00

abstract：:Until recently, drug development in oncology was focused on treating most patients for a specific cancer type without taking in account the heterogeneity between these patients in term of response to treatment. Therefore, this type of broad treatment approach excludes the treatment of patient not responding to disease...

journal_title：Epigenomics

authors： Cartron PF,Cheray M,Bretaudeau L

更新日期：2020-01-01 00:00:00