Abstract:
:This article focuses on the epigenetic alterations of aberrant promoter hypermethylation of genes, and histone modifications or RNA interference in cancer cells. Current knowledge of the hypermethylation of allele(s) in classical tumor suppressor genes in inherited and sporadic cancer, candidate tumor suppressor and other cancer genes is summarized gene by gene. Global and array-based studies of tumor cell hypermethylation are discussed. The importance of standardization of scoring of the methylation status of a gene is highlighted. The histone marks associated with hypermethylated genes, and the miRNAs with dysregulated expression, in kidney or bladder tumor cells are also discussed. Kidney cancer has the highest mortality rate of the genito-urinary cancers. There are management issues associated with the high recurrence rate of superficial bladder cancer, while muscle-invasive bladder cancer has a poor prognosis. These clinical problems are the basis for the translational application of gene hypermethylation in the diagnosis and prognosis of kidney and bladder cancer.
journal_name
Epigenomicsjournal_title
Epigenomicsauthors
Hoffman AM,Cairns Pdoi
10.2217/epi.10.64subject
Has Abstractpub_date
2011-02-01 00:00:00pages
19-34issue
1eissn
1750-1911issn
1750-192Xjournal_volume
3pub_type
杂志文章,评审相关文献
Epigenomics文献大全abstract:AIM:The isoflavones genistein, daidzein and equol (daidzein metabolite) have been reported to interact with epigenetic modifications, specifically hypermethylation of tumor suppressor genes. The objective of this study was to analyze and understand the mechanisms by which phytoestrogens act on chromatin in breast cance...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi.12.74
更新日期:2013-02-01 00:00:00
abstract::Aim: To examine the impact of 4-nonylphenol (4-NP), on the expression of polycomb repressive complexes and cellular proliferation. Materials & methods: Cell proliferation assays, quantitative PCR, Western blotting, luciferase reporter assay, chromatin immunoprecipitation-quantitative PCR were used for the study. Resul...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2018-0175
更新日期:2019-06-01 00:00:00
abstract::Epigenetic enzymes are emerging as crucial controllers of macrophages, innate immune cells that determine the outcome of many inflammatory diseases. Recent studies demonstrate that the activity of particular chromatin-modifying enzymes is regulated by the availability of specific metabolites like acetyl-coenzyme A, S-...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi.15.71
更新日期:2015-10-01 00:00:00
abstract:AIM:To identify differentially methylated probes (DMPs) and regions (DMRs) in relation to chronic obstructive pulmonary disease (COPD) and lung function traits. METHODS:We performed an epigenome-wide association study of COPD and spirometric parameters, including forced expiratory volume in 1 s (FEV1), forced vital ca...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2017-0002
更新日期:2017-07-01 00:00:00
abstract::The examination of potential roles of epigenetic alterations in the pathogenesis of psychotic diseases have become an essential alternative in recent years as genetic studies alone are yet to uncover major gene(s) for psychosis. Here, we describe the current state of knowledge from the gene-specific and genome-wide st...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.14.85
更新日期:2015-01-01 00:00:00
abstract:AIM:In order to identify regulators of foam cells, we studied the H3K27 demethylase Kdm6b (also known as Jmjd3), a known regulator of macrophages, in controlling the transcriptional profile of foam cells. MATERIALS & METHODS:Foam cells from Kdm6b-deleted or Kdm6b wild-type mice were isolated and used for RNA-sequencin...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2016-0152
更新日期:2017-04-01 00:00:00
abstract:AIM:In nondividing neurons examine the role of Gadd45b in active 5-methylcytosine (5MC) and 5-hydroxymethylcytosine (5HMC) removal at a gene promoter highly implicated in mental illnesses and cognition, Bdnf. MATERIALS & METHODS:Mouse primary cortical neuronal cultures with and without Gadd45b siRNA transfection were ...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi.15.12
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To study DNA methylation patterns of cortical pyramidal layers susceptible to late-onset Alzheimer's disease (LOAD) neurodegeneration. METHODS:Laser-assisted microdissection to select pyramidal layers' cells in frontal cortex of 32 human brains (18 LOAD) and Infinium DNA Methylation 450K analysis were perfor...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2017-0160
更新日期:2018-11-01 00:00:00
abstract::Aim: The hygiene hypothesis states that a lack of infection in early-life suppresses immune system development, and is linked to respiratory allergy (RA) and childhood acute lymphoblastic leukemia (ALL) risk. Little is known about underlying mechanisms, but DNA methylation is altered in RA and ALL, and in response to ...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2019-0052
更新日期:2019-10-01 00:00:00
abstract::DNA methylation is widely studied in the context of cancer. However, the rediscovery of 5-hydroxymethylation of DNA adds a new layer of complexity to understanding the epigenetic basis of development and disease, including carcinogenesis. There have been significant advances in techniques for the detection of 5-hydrox...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.13.69
更新日期:2013-12-01 00:00:00
abstract::Aim: The role of circRNAs in esophageal squamous cell cancer (ESCC) remains unclear. Materials & methods: Here we profiled six pair plasma circRNA in ESCC based on RNA sequencing, and then verified the elevation of hsa_circ_0004771 in 20 cancer tissues and 105 pair case-control plasma samples by quantitative reverse t...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2019-0404
更新日期:2020-04-01 00:00:00
abstract::Until recently, drug development in oncology was focused on treating most patients for a specific cancer type without taking in account the heterogeneity between these patients in term of response to treatment. Therefore, this type of broad treatment approach excludes the treatment of patient not responding to disease...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2019-0169
更新日期:2020-01-01 00:00:00
abstract::Idiopathic pulmonary fibrosis (IPF) is a complex lung disease of unknown etiology. Development of IPF is influenced by both genetic and environmental factors. Gene-expression profiling studies have taught us quite a bit about the biology of this fatal disease, but epigenetic marks may be the missing link that connects...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.12.10
更新日期:2012-04-01 00:00:00
abstract::The widely accepted association between aberrant methylation at specific imprinted loci and distinct imprinting disorders has recently been brought into question by the identification of methylation defects at multiple loci (multilocus methylation defect [MLMD]). Strikingly, in different imprinting disorders, the same...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.11.84
更新日期:2011-10-01 00:00:00
abstract::Stephen B Baylin is a codirector of the Cancer Biology Program at The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and the Virginia and DK Ludwig Professor of Oncology and Medicine. Baylin attended Duke University, where he earned his medical degree and completed his internship and first year residency i...
journal_title:Epigenomics
pub_type: 面试
doi:10.2217/epi.15.61
更新日期:2015-01-01 00:00:00
abstract:AIM:To identify regions of aberrant DNA methylation in acute lymphoblastic leukemia (ALL) cells of different subtypes on a genome-wide scale. MATERIALS & METHODS:Whole-genome bisulfite sequencing (WGBS) was used to determine the DNA methylation levels in cells from four pediatric ALL patients of different subtypes. Th...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2016-0052
更新日期:2016-10-01 00:00:00
abstract::Antisense RNA is the first noncoding RNA found to have a regulatory function. With the advances of biological science, it has been recognized that the function of antisense RNAs is not only limited to post-transcriptional regulation, but extends to transcriptional regulation of various important genes leading to epige...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.09.46
更新日期:2010-02-01 00:00:00
abstract:AIM:To assess the correlation between KDM6B and estrogen receptor β (ERβ) expression in malignant pleural mesothelioma (MPM). MATERIALS & METHODS:We evaluated gene expression by in silico analysis of microarray data, real-time PCR and western blot in MPM tumors and cell lines. RESULTS & CONCLUSION:We report a strong ...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2016-0025
更新日期:2016-09-01 00:00:00
abstract:AIM:To assess the associations between gestational diabetes mellitus (GDM) and DNA methylation levels at genes related to energy metabolism. PATIENTS & METHODS:Ten loci were selected from our recent epigenome-wide association study on GDM. DNA methylation levels were quantified by bisulfite pyrosequencing in 80 placen...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi.15.72
更新日期:2015-10-01 00:00:00
abstract:AIM:Disclosing the mechanisms that regulate reprogramming memory. MATERIALS & METHODS:We established computational procedure to find DNA methylation somatic memory sites (SMSs) at single CpGs and integrated them with genomics, epigenomics, transcriptomics and imprinting information. RESULTS & CONCLUSION:Reprogramming...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2017-0098
更新日期:2018-02-01 00:00:00
abstract:AIM:There is a growing concern about the potential adverse effects of high dose folic acid (FA) supplementation before and during pregnancy. FA metabolism generates S-adenosyl methionine (SAM) which is an important cofactor of epigenetic programming. We sought to assess the impact of a large dose of SAM on early embryo...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2016-0022
更新日期:2016-08-01 00:00:00
abstract::This study aimed to unveil the functional roles of LINC00221 in hepatocellular carcinoma (HCC). A discovery cohort and a validation cohort were respectively used to identify and verify the clinical value of LINC00221 in HCC. Bioinformatics analysis was performed to explore its potential mechanisms. LINC00221 was upreg...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2020-0363
更新日期:2021-01-07 00:00:00
abstract:AIM:We performed a study to identify the role of microRNA in thymoma. PATIENTS & METHODS:One hundred twenty-three thymoma patients with clinical information and miRNA expression data from The Cancer Genome Atlas were included in the study. Comprehensive bioinformatics analysis was integrated in our analysis. RESULTS ...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2016-0161
更新日期:2017-05-01 00:00:00
abstract::Aberrant epigenomic programming is a hallmark of acute myeloid leukemia. This is partially due to somatic mutations that perturb cytosine methylation, histone post-translational modifications and transcription factors. Remarkably, mutations in the IDH1 and IDH2 genes perturb the epigenome through all three of these me...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi-2016-0008
更新日期:2016-07-01 00:00:00
abstract::There are numerous examples of enduring effects of early experience on gene transcription and neural function. We review the emerging evidence for epigenetics as a candidate mechanism for such effects. There is now evidence that intracellular signals activated by environmental events can directly modify the epigenetic...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.09.21
更新日期:2009-10-01 00:00:00
abstract::The Medical Research Council Clinical Sciences Centre Symposium on Epigenetic Regulation: From Mechanism to Intervention in London, UK, which was held on 20-22 June 2012, attracted 305 participants from around the globe and included 37 speakers and 85 selected poster presentations. The organizing committee, led by Nia...
journal_title:Epigenomics
pub_type: 新闻
doi:10.2217/epi.12.47
更新日期:2012-10-01 00:00:00
abstract:AIMS:To investigate if DNA methylation pattern assay could be a new approach to identifying the primary tumor cell origin of the recurrent hepatocellular carcinoma (HCC). MATERIALS & METHODS:Methylation of 24 genes and expression of 22 cancer stem cell (CSC) biomarkers were quantitatively measured in 10 paired primary...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi.15.23
更新日期:2015-01-01 00:00:00
abstract::Epigenetic modifications established during gametogenesis regulate transcription and other nuclear processes in gametes, but also have influences in the zygote, embryo and postnatal life. This is best understood for DNA methylation which, established at discrete regions of the oocyte and sperm genomes, governs genomic...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi-2016-0056
更新日期:2016-10-01 00:00:00
abstract::DNA modifications represent an integral part of the epigenome and they have a pivotal role in regulation of genome function. Despite the wide variety of analytical techniques that have been developed to detect DNA modifications, their investigation at the single-genome level is only beginning to emerge. In contrast to...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.12.30
更新日期:2012-08-01 00:00:00
abstract::Alterations in DNA methylation have been associated with cognitive decline and Alzheimer's disease. A recent study of mild cognitive impairment (MCI) reported a significant association between annual decline in cognitive function and the rs11887120 SNP located in DNMT3A, a gene implicated in DNA methylation. Here, we ...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2015-0014
更新日期:2016-05-01 00:00:00