Abstract:
:Arsenic is a nonmutagenic human carcinogen that induces tumors through unknown mechanisms. A growing body of evidence suggests that its carcinogenicity results from epigenetic changes, particularly in DNA methylation. Changes in gene methylation status, mediated by arsenic, have been proposed to activate oncogene expression or silence tumor suppressor genes, leading to long-term changes in the activity of genes controlling cell transformation. Mostly descriptive, and often contradictory, studies have demonstrated that arsenic exposure is associated with both hypo- and hyper-methylation at various genetic loci in vivo or in vitro. This ambiguity has made it difficult to assess whether the changes induced by arsenic are causally involved in the transformation process or are simply a reflection of the altered physiology of rapidly dividing cancer cells. Here, we discuss the evidence supporting changes in DNA methylation as a cause of arsenic carcinogenesis and highlight the strengths and limitations of these studies, as well as areas where consistencies and inconsistencies exist.
journal_name
Epigenomicsjournal_title
Epigenomicsauthors
Reichard JF,Puga Adoi
10.2217/epi.09.45subject
Has Abstractpub_date
2010-02-01 00:00:00pages
87-104issue
1eissn
1750-1911issn
1750-192Xjournal_volume
2pub_type
杂志文章,评审相关文献
Epigenomics文献大全abstract::Aim: To dynamically analyze the differential m6A methylation during the progression and reversal of hepatic fibrosis. Materials & methods: We induced hepatic fibrosis in C57/BL6 mice by intraperitoneal injection of CCl4. The reversal model of hepatic fibrosis was established by stopping drug after continuous injection...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2019-0365
更新日期:2020-10-01 00:00:00
abstract::The E3 ubiquitin ligase UBE3A, also known as E6-AP, has a multitude of ascribed functions and targets relevant to human health and disease. Epigenetic regulation of the UBE3A gene by parentally imprinted noncoding transcription within human chromosome 15q11.2-q13.3 is responsible for the maternal-specific effects of 1...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.15.70
更新日期:2015-10-01 00:00:00
abstract:AIM:The isoflavones genistein, daidzein and equol (daidzein metabolite) have been reported to interact with epigenetic modifications, specifically hypermethylation of tumor suppressor genes. The objective of this study was to analyze and understand the mechanisms by which phytoestrogens act on chromatin in breast cance...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi.12.74
更新日期:2013-02-01 00:00:00
abstract::Aim: The hygiene hypothesis states that a lack of infection in early-life suppresses immune system development, and is linked to respiratory allergy (RA) and childhood acute lymphoblastic leukemia (ALL) risk. Little is known about underlying mechanisms, but DNA methylation is altered in RA and ALL, and in response to ...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2019-0052
更新日期:2019-10-01 00:00:00
abstract::A number of bioactive dietary components are of particular interest in the field of epigenetics. Many of these compounds display anticancer properties and may play a role in cancer prevention. Numerous studies suggest that a number of nutritional compounds have epigenetic targets in cancer cells. Importantly, emerging...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.11.71
更新日期:2011-08-01 00:00:00
abstract::Epigenetic enzymes are emerging as crucial controllers of macrophages, innate immune cells that determine the outcome of many inflammatory diseases. Recent studies demonstrate that the activity of particular chromatin-modifying enzymes is regulated by the availability of specific metabolites like acetyl-coenzyme A, S-...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi.15.71
更新日期:2015-10-01 00:00:00
abstract:AIM:To identify DNA methylation biomarkers in peripheral blood samples from triple-negative breast cancer (TNBC) patients. MATERIALS & METHODS:We conducted an epigenome-wide association study (EWAS): the most promising markers were identified in 233 TNBC case-control pairs (discovery set) and subsequently validated in...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2018-0121
更新日期:2019-01-01 00:00:00
abstract:AIM:In order to identify regulators of foam cells, we studied the H3K27 demethylase Kdm6b (also known as Jmjd3), a known regulator of macrophages, in controlling the transcriptional profile of foam cells. MATERIALS & METHODS:Foam cells from Kdm6b-deleted or Kdm6b wild-type mice were isolated and used for RNA-sequencin...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2016-0152
更新日期:2017-04-01 00:00:00
abstract::Aim: This study aimed to identify novel miRNAs (miRs) as regulators of UGT1A gene expression and to evaluate them as potential risk factors for the development of liver fibrosis/cirrhosis. Materials & methods: miRNA target sites in UDP-glucuronosyltransferase 1A (UGT1A) 3'-UTR were predicted and confirmed by luciferas...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2020-0244
更新日期:2021-01-12 00:00:00
abstract::Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is widely used for mapping histone modifications, histone proteins, chromatin regulators, transcription factors and other DNA-binding proteins. It has played a significant role in our understanding of disease mechanisms and in exploring epigenetic changes...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi-2016-0053
更新日期:2016-09-01 00:00:00
abstract::Aim: To uncover a novel lncRNA-miRNA-mRNA network associated with high-grade serous ovarian cancer metastasis. Material & methods: The candidate differentially expressed lncRNAs were obtained from RNA-sequencing data and determined by functional experiments. The downstream miRNAs and mRNAs were identified by bioinform...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2020-0097
更新日期:2020-07-01 00:00:00
abstract::There are numerous examples of enduring effects of early experience on gene transcription and neural function. We review the emerging evidence for epigenetics as a candidate mechanism for such effects. There is now evidence that intracellular signals activated by environmental events can directly modify the epigenetic...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.09.21
更新日期:2009-10-01 00:00:00
abstract:AIMS:Epigenetic signatures of germline cells are dynamically reprogrammed to induce appropriate differentiation, development and sex specification. We investigated sex-specific epigenetic changes in mouse fetal germ cells (FGCs) and neonatal germ cells. MATERIALS & METHODS:Six histone marks in mouse E13.5 FGCs and P1 ...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2018-0193
更新日期:2019-04-01 00:00:00
abstract::Aim: To develop a method for estimating cell-specific effects in epigenomic association studies in the presence of cell type heterogeneity. Materials & methods: We utilized Monte Carlo Expectation-Maximization (MCEM) algorithm with Metropolis-Hastings sampler to reconstruct the 'missing' cell-specific methylations and...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2020-0147
更新日期:2020-12-22 00:00:00
abstract::DNA modifications represent an integral part of the epigenome and they have a pivotal role in regulation of genome function. Despite the wide variety of analytical techniques that have been developed to detect DNA modifications, their investigation at the single-genome level is only beginning to emerge. In contrast to...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.12.30
更新日期:2012-08-01 00:00:00
abstract::Antisense RNA is the first noncoding RNA found to have a regulatory function. With the advances of biological science, it has been recognized that the function of antisense RNAs is not only limited to post-transcriptional regulation, but extends to transcriptional regulation of various important genes leading to epige...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.09.46
更新日期:2010-02-01 00:00:00
abstract::The ability to culture pluripotent stem cells and direct their differentiation into specific cell types in vitro provides a valuable experimental system for modeling pluripotency, development and cellular differentiation. High-throughput profiling of the transcriptomes and epigenomes of pluripotent stem cells and thei...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.13.80
更新日期:2014-02-01 00:00:00
abstract:AIM:In nondividing neurons examine the role of Gadd45b in active 5-methylcytosine (5MC) and 5-hydroxymethylcytosine (5HMC) removal at a gene promoter highly implicated in mental illnesses and cognition, Bdnf. MATERIALS & METHODS:Mouse primary cortical neuronal cultures with and without Gadd45b siRNA transfection were ...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi.15.12
更新日期:2015-01-01 00:00:00
abstract:AIM:Disclosing the mechanisms that regulate reprogramming memory. MATERIALS & METHODS:We established computational procedure to find DNA methylation somatic memory sites (SMSs) at single CpGs and integrated them with genomics, epigenomics, transcriptomics and imprinting information. RESULTS & CONCLUSION:Reprogramming...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2017-0098
更新日期:2018-02-01 00:00:00
abstract::Cancer numbers increasing, cases heterogeneity and the drug resistance emergence have pushed scientists to search for innovative solutions for patients and epimutations can be one. Methylated DNA, modified nucleosomes and noncoding RNAs are found in all cells, including tumor cells. They are intracellular actors but a...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2019-0170
更新日期:2020-01-01 00:00:00
abstract::Aim: This study aims to examine the DNA methylation (DNAm) and expression patterns of genes associated with placental angiogenesis in preeclampsia. Materials & methods: DNAm and expression were examined in normotensive (n = 100) and preeclampsia (n = 100) women using pyrosequencing and quantitative real-time PCR respe...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2020-0318
更新日期:2021-01-20 00:00:00
abstract::Aim: The role of circRNAs in esophageal squamous cell cancer (ESCC) remains unclear. Materials & methods: Here we profiled six pair plasma circRNA in ESCC based on RNA sequencing, and then verified the elevation of hsa_circ_0004771 in 20 cancer tissues and 105 pair case-control plasma samples by quantitative reverse t...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2019-0404
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:To study DNA methylation patterns of cortical pyramidal layers susceptible to late-onset Alzheimer's disease (LOAD) neurodegeneration. METHODS:Laser-assisted microdissection to select pyramidal layers' cells in frontal cortex of 32 human brains (18 LOAD) and Infinium DNA Methylation 450K analysis were perfor...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2017-0160
更新日期:2018-11-01 00:00:00
abstract::Prader-Willi syndrome (PWS) is a relatively rare disorder that originates from paternally inherited deletions and maternal disomy (mUPD) within the 15q11-q13 region or alterations in the PWS imprinting center. Evidence is accumulating that mUPD underlies high prevalence of psychosis among PWS patients. Several genes i...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.14.52
更新日期:2014-01-01 00:00:00
abstract::Aim: To assess isorhamnetin efficacy for diabetic kidney disease in a Type 2 diabetes mellitus rat model, through investigating its effect at the epigenetic, mRNA and protein levels. Materials & methods: Type 2 diabetes mellitus was induced in rats by streptozotocin and high-fat diet. Rats were treated with isorhamnet...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2020-0353
更新日期:2021-01-07 00:00:00
abstract:AIM:To assess the correlation between KDM6B and estrogen receptor β (ERβ) expression in malignant pleural mesothelioma (MPM). MATERIALS & METHODS:We evaluated gene expression by in silico analysis of microarray data, real-time PCR and western blot in MPM tumors and cell lines. RESULTS & CONCLUSION:We report a strong ...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2016-0025
更新日期:2016-09-01 00:00:00
abstract::Children exposed to early-life adversity carry a greater risk of poor health and disease into adulthood. This increased disease risk is shadowed by changes in the epigenome. Epigenetics can change gene expression to modify disease risk; unfortunately, how epigenetics are changed by the environment is unclear. It is kn...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.15.74
更新日期:2015-10-01 00:00:00
abstract::DNA methylation is widely studied in the context of cancer. However, the rediscovery of 5-hydroxymethylation of DNA adds a new layer of complexity to understanding the epigenetic basis of development and disease, including carcinogenesis. There have been significant advances in techniques for the detection of 5-hydrox...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.13.69
更新日期:2013-12-01 00:00:00
abstract::Melanoma is a leading cause of death from cancers in the USA. While exposure to UV radiation has long been identified as a primary risk factor for melanoma, molecular mechanisms directly linking UV radiation to the development of melanoma, especially metastatic melanoma, are poorly understood. Besides abnormality in s...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.11.114
更新日期:2012-02-01 00:00:00
abstract::Asthma is a chronic disease which causes recurrent breathlessness affecting 300 million people worldwide of whom 250,000 die annually. The epigenome is a set of heritable modifications and tags that affect the genome without changing the intrinsic DNA sequence. These marks include DNA methylation, modifications to his...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.15.53
更新日期:2015-01-01 00:00:00