Abstract:
AIM:In order to identify regulators of foam cells, we studied the H3K27 demethylase Kdm6b (also known as Jmjd3), a known regulator of macrophages, in controlling the transcriptional profile of foam cells. MATERIALS & METHODS:Foam cells from Kdm6b-deleted or Kdm6b wild-type mice were isolated and used for RNA-sequencing analysis. RESULTS:Pathway analysis revealed that pro-fibrotic pathways were strongly suppressed in Kdm6b-deleted foam cells. Analysis of published datasets showed that foam cell formation induces these pro-fibrotic characteristics. Overlay of both datasets indicated that fibrotic genes which are induced upon foam cell formation, are reduced in the absence of Kdm6b. These data suggest that foam cell formation induces a pro-fibrotic gene signature in a Kdm6b-dependent manner. CONCLUSION:We identified Kdm6b as a novel regulator of the pro-fibrotic signature of peritoneal foam cells.
journal_name
Epigenomicsjournal_title
Epigenomicsauthors
Neele AE,Prange KH,Hoeksema MA,van der Velden S,Lucas T,Dimmeler S,Lutgens E,Van den Bossche J,de Winther MPdoi
10.2217/epi-2016-0152subject
Has Abstractpub_date
2017-04-01 00:00:00pages
383-391issue
4eissn
1750-1911issn
1750-192Xjournal_volume
9pub_type
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