Abstract:
:Aim: To identify lncRNAs targeting GSK3β in MDD. Materials & methods: The levels of GSK3β and its three targeting lncRNAs (gsk3β antisense AS1, AS2 and AS3) were detected in 52 patients with major depressive disorder (MDD) before and after 8 weeks of escitalopram treatment. The functional study was evaluated using the silence of lncR-gsk3βAS2/3. The correlation between lncRNA-gsk3β and 89 MDD patients was analyzed. Human neuron progenitor cells were used to investigate the functional role of lncRNA-gsk3β in MDD. Results: All three lncRNAs were downregulated in MDD patients but upregulated after treatment. Inhibition of gsk3βAS2/3 reduced GSK3β expression and its phosphorylation levels in the neuron progenitor cells. Conclusion: Our findings suggest that lncRNA-gsk3βAS3 regulates GSK3β activity in MDD and has potential as a novel therapeutic target.
journal_name
Epigenomicsjournal_title
Epigenomicsauthors
Liu Z,Li X,Chen C,Sun N,Wang Y,Yang C,Xu Y,Xu Y,Zhang Kdoi
10.2217/epi-2019-0402subject
Has Abstractpub_date
2020-10-01 00:00:00pages
1725-1738issue
19eissn
1750-1911issn
1750-192Xjournal_volume
12pub_type
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