Abstract:
:Neuromuscular disorders are a heterogeneous group of conditions affecting the neuromuscular system. The aim of this article is to review the major epigenetic findings in motor neuron diseases and major hereditary muscular dystrophies. DNA methylation changes are observed in both hereditary and sporadic forms, and combining DNA methylation analysis with mutational screening holds the potential for better diagnostic and prognostic accuracy. Novel, less toxic and more selective epigenetic drugs are designed and tested in animal and cell culture models of neuromuscular disorders, and non-coding RNAs are being investigated as either disease biomarkers or targets of therapeutic approaches to restore gene expression levels. Overall, neuromuscular disorder epigenetic biomarkers have a strong potential for clinical applications in the near future.
journal_name
Epigenomicsjournal_title
Epigenomicsauthors
Coppedè Fdoi
10.2217/epi-2020-0282subject
Has Abstractpub_date
2020-12-01 00:00:00pages
2125-2139issue
23eissn
1750-1911issn
1750-192Xjournal_volume
12pub_type
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