Current and potential epigenetic targets in multiple myeloma.

abstract：:Aim: To assess isorhamnetin efficacy for diabetic kidney disease in a Type 2 diabetes mellitus rat model, through investigating its effect at the epigenetic, mRNA and protein levels. Materials & methods: Type 2 diabetes mellitus was induced in rats by streptozotocin and high-fat diet. Rats were treated with isorhamnet...

journal_title：Epigenomics

authors： Matboli M,Ibrahim D,Hasanin AH,Hassan MK,Habib EK,Bekhet MM,Afifi AM,Eissa S

更新日期：2021-01-07 00:00:00

abstract：AIM:Imprinted genes exhibit expression in a parent-of-origin-dependent manner and are critical for child development. Recent limited evidence suggests that prenatal exposure to phthalates, ubiquitous endocrine disruptors, can affect their epigenetic dysregulation. MATERIALS & METHODS:We quantified DNA methylation of n...

journal_title：Epigenomics

authors： Tindula G,Murphy SK,Grenier C,Huang Z,Huen K,Escudero-Fung M,Bradman A,Eskenazi B,Hoyo C,Holland N

更新日期：2018-07-01 00:00:00

abstract：:Melanoma is a leading cause of death from cancers in the USA. While exposure to UV radiation has long been identified as a primary risk factor for melanoma, molecular mechanisms directly linking UV radiation to the development of melanoma, especially metastatic melanoma, are poorly understood. Besides abnormality in s...

journal_title：Epigenomics

authors： Perera RJ,Ray A

更新日期：2012-02-01 00:00:00

abstract：:Aim: The contribution of miRNAs as epigenetic regulators of sexually dimorphic gene expression in the placenta is unknown. Materials & methods: 382 placentas from the extremely low gestational age newborns (ELGAN) cohort were evaluated for expression levels of 37,268 mRNAs and 2,102 miRNAs using genome-wide RNA-sequen...

journal_title：Epigenomics

authors： Eaves LA,Phookphan P,Rager JE,Bangma J,Santos HP Jr,Smeester L,O'Shea TM,Fry RC

更新日期：2020-09-01 00:00:00

abstract：:DNA methylation is widely studied in the context of cancer. However, the rediscovery of 5-hydroxymethylation of DNA adds a new layer of complexity to understanding the epigenetic basis of development and disease, including carcinogenesis. There have been significant advances in techniques for the detection of 5-hydrox...

journal_title：Epigenomics

authors： Laird A,Thomson JP,Harrison DJ,Meehan RR

更新日期：2013-12-01 00:00:00

abstract：:The examination of potential roles of epigenetic alterations in the pathogenesis of psychotic diseases have become an essential alternative in recent years as genetic studies alone are yet to uncover major gene(s) for psychosis. Here, we describe the current state of knowledge from the gene-specific and genome-wide st...

journal_title：Epigenomics

authors： Abdolmaleky HM,Zhou JR,Thiagalingam S

更新日期：2015-01-01 00:00:00

abstract：:Cancer numbers increasing, cases heterogeneity and the drug resistance emergence have pushed scientists to search for innovative solutions for patients and epimutations can be one. Methylated DNA, modified nucleosomes and noncoding RNAs are found in all cells, including tumor cells. They are intracellular actors but a...

journal_title：Epigenomics

authors： Duforestel M,Briand J,Bougras-Cartron G,Heymann D,Frenel JS,Vallette FM,Cartron PF

更新日期：2020-01-01 00:00:00

abstract：:Aim: This study aims to examine the DNA methylation (DNAm) and expression patterns of genes associated with placental angiogenesis in preeclampsia. Materials & methods: DNAm and expression were examined in normotensive (n = 100) and preeclampsia (n = 100) women using pyrosequencing and quantitative real-time PCR respe...

journal_title：Epigenomics

authors： M Dave K,Kaur L,Randhir KN,Mehendale SS,Sundrani DP,Chandak GR,Joshi SR

更新日期：2021-01-20 00:00:00

abstract：:Prader-Willi syndrome (PWS) is a relatively rare disorder that originates from paternally inherited deletions and maternal disomy (mUPD) within the 15q11-q13 region or alterations in the PWS imprinting center. Evidence is accumulating that mUPD underlies high prevalence of psychosis among PWS patients. Several genes i...

journal_title：Epigenomics

authors： Krefft M,Frydecka D,Adamowski T,Misiak B

更新日期：2014-01-01 00:00:00

abstract：AIM:This study aims to couple DNA methylation changes and evolution of retrogenes. MATERIALS & METHODS:A new two-step strategy was developed to screen retrogenes. Further, reduced representation bisulfite sequencing and RNA-seq data of eight tissues were used to analyze retrogenes. RESULTS:A total of 964 retrocopies ...

journal_title：Epigenomics

authors： Fang C,Zou C,Fu Y,Li J,Li Y,Ma Y,Zhao S,Li C

更新日期：2018-02-01 00:00:00

abstract：AIM:There is a growing concern about the potential adverse effects of high dose folic acid (FA) supplementation before and during pregnancy. FA metabolism generates S-adenosyl methionine (SAM) which is an important cofactor of epigenetic programming. We sought to assess the impact of a large dose of SAM on early embryo...

journal_title：Epigenomics

authors： Shojaei Saadi HA,Gagné D,Fournier É,Baldoceda Baldeon LM,Sirard MA,Robert C

更新日期：2016-08-01 00:00:00

abstract：:Histone deacetylase (HDAC)6 is a member of the class IIb HDAC family. This enzyme is zinc-dependent and mainly localized in the cytoplasm. HDAC6 is a unique isoenzyme with two functional catalytic domains and specific physiological roles. Indeed, HDAC6 deacetylates various substrates including α-tubulin and HSP90α, an...

journal_title：Epigenomics

authors： Seidel C,Schnekenburger M,Dicato M,Diederich M

更新日期：2015-01-01 00:00:00

abstract：:Currently, the incidence of colorectal cancer (CRC) is increasing across the world. The cancer stroma exerts an impact on the spread, invasion and chemoresistance of CRC. The tumor microenvironment involves a complex interaction between cancer cells and stromal cells, for example, cancer-associated fibroblasts (CAFs)....

journal_title：Epigenomics

authors： Savardashtaki A,Shabaninejad Z,Movahedpour A,Sahebnasagh R,Mirzaei H,Hamblin MR

更新日期：2019-11-01 00:00:00

abstract：:Aim: To determine changes in global DNA methylation in monocytes from neonates of women with obesity, as markers of an immune programming resulting from maternal obesity. Materials & methods: Cord blood monocytes were obtained from neonates born to women with obesity and normal weight, genome-wide differentially methy...

journal_title：Epigenomics

authors： Vega-Tapia F,Artigas R,Hernández C,Uauy R,Casanello P,Krause BJ,Castro-Rodriguez JA

更新日期：2020-11-01 00:00:00

abstract：AIM:To investigate epigenomic changes in pregnancy and early postpartum in women with and without type 2 diabetes. METHODS:Dimethylation of histones H3K4, H3K9, H3K27, H3K36 and H3K79 was measured in white blood cells of women at 30 weeks pregnancy, at 8-10 and 20 weeks postpartum and in never-pregnant women. RESULTS...

journal_title：Epigenomics

authors： Michalczyk AA,Janus ED,Judge A,Ebeling PR,Best JD,Ackland MJ,Asproloupos D,Dunbar JA,Ackland ML

更新日期：2018-04-01 00:00:00

abstract：:Aim: We examined methylation changes in cell-free DNA (cfDNA) in metastatic castration-resistant prostate cancer (mCRPC) during treatment. Patients & methods: Genome-wide methylation analysis of sequentially collected cfDNA samples derived from mCRPC patients undergoing androgen-targeting therapy was performed. Result...

journal_title：Epigenomics

authors： Peter MR,Bilenky M,Isserlin R,Bader GD,Shen SY,De Carvalho DD,Hansen AR,Hu P,Fleshner NE,Joshua AM,Hirst M,Bapat B

更新日期：2020-08-01 00:00:00

abstract：:DNA modifications represent an integral part of the epigenome and they have a pivotal role in regulation of genome function. Despite the wide variety of analytical techniques that have been developed to detect DNA modifications, their investigation at the single-genome level is only beginning to emerge. In contrast to...

journal_title：Epigenomics

authors： Zillner K,Németh A

更新日期：2012-08-01 00:00:00

abstract：:Asthma is a chronic disease which causes recurrent breathlessness affecting 300 million people worldwide of whom 250,000 die annually. The epigenome is a set of heritable modifications and tags that affect the genome without changing the intrinsic DNA sequence. These marks include DNA methylation, modifications to his...

journal_title：Epigenomics

authors： Brook PO,Perry MM,Adcock IM,Durham AL

更新日期：2015-01-01 00:00:00

abstract：:Aim: To develop a method for estimating cell-specific effects in epigenomic association studies in the presence of cell type heterogeneity. Materials & methods: We utilized Monte Carlo Expectation-Maximization (MCEM) algorithm with Metropolis-Hastings sampler to reconstruct the 'missing' cell-specific methylations and...

journal_title：Epigenomics

authors： Feng YA,Guo Y,Pain L,Lathrop GM,Laprise C,Moffatt MF,Cookson WO,Liang L

更新日期：2020-12-22 00:00:00

abstract：:Hematopoiesis is a regulated multistep process, whereby transcriptional and epigenetic events contribute to progenitor fate determination. miRNAs have emerged as key players in hematopoietic cell development, differentiation and malignant transformation. From embryonic development through to adult life, miRNAs coopera...

journal_title：Epigenomics

authors： Pagano F,De Marinis E,Grignani F,Nervi C

更新日期：2013-01-01 00:00:00

abstract：AIM:To develop a reliable method for whole genome analysis of DNA methylation. MATERIALS & METHODS:Genome-scale analysis of DNA methylation includes affinity-based approaches such as enrichment using methyl-CpG-binding proteins. One of these methods, the methylated-CpG island recovery assay (MIRA), is based on the hig...

journal_title：Epigenomics

authors： Jung M,Kadam S,Xiong W,Rauch TA,Jin SG,Pfeifer GP

更新日期：2015-08-01 00:00:00

abstract：:For the first time, the development of next-generation sequencing technologies has brought about tools to investigate epigenetic alterations in an unbiased, yet genome-wide approach. The importance of this innovative technology is undeniable since it has already been established that changes in DNA methylation play an...

journal_title：Epigenomics

authors： Boerno ST,Grimm C,Lehrach H,Schweiger MR

更新日期：2010-04-01 00:00:00

abstract：:Aim: To examine the impact of 4-nonylphenol (4-NP), on the expression of polycomb repressive complexes and cellular proliferation. Materials & methods: Cell proliferation assays, quantitative PCR, Western blotting, luciferase reporter assay, chromatin immunoprecipitation-quantitative PCR were used for the study. Resul...

journal_title：Epigenomics

authors： Ghosh K,Chatterjee B,Maheswari U,Athifa M,Kanade SR

更新日期：2019-06-01 00:00:00

abstract：:Post-translational modifications of chromatin have become a 'booming' area of biomedical research. One particularly interesting modification that is important for eukaryotic gene expression is trimethylation of histone H3 lysine 4 (H3K4me3), which is almost exclusively associated with active promoters of RNA polymeras...

journal_title：Epigenomics

authors： Vermeulen M,Timmers HT

更新日期：2010-06-01 00:00:00

abstract：:The Medical Research Council Clinical Sciences Centre Symposium on Epigenetic Regulation: From Mechanism to Intervention in London, UK, which was held on 20-22 June 2012, attracted 305 participants from around the globe and included 37 speakers and 85 selected poster presentations. The organizing committee, led by Nia...

journal_title：Epigenomics

authors： Chatterjee A

更新日期：2012-10-01 00:00:00

abstract：:Aim: To identify pregnancy-associated changes in cervical noncoding RNA (ncRNA), including miRNA and long noncoding RNA (lncRNA), and their potential effects on biologic processes. Materials & methods: We enrolled 21 pregnant women with term deliveries (≥37 weeks' gestation) in a prospective cohort and collected cervi...

journal_title：Epigenomics

authors： Gerson KD,Haviland MJ,Neo D,Hecht JL,Baccarelli AA,Brennan KJ,Dereix AE,Ralston SJ,Hacker MR,Burris HH

更新日期：2020-06-01 00:00:00

abstract：:Aim: This study aimed to identify novel miRNAs (miRs) as regulators of UGT1A gene expression and to evaluate them as potential risk factors for the development of liver fibrosis/cirrhosis. Materials & methods: miRNA target sites in UDP-glucuronosyltransferase 1A (UGT1A) 3'-UTR were predicted and confirmed by luciferas...

journal_title：Epigenomics

authors： Paulusch S,Kalthoff S,Landerer S,Jansen C,Schierwagen R,Klein S,Trebicka J,Strassburg CP

更新日期：2021-01-12 00:00:00

abstract：:Aim: The role of circRNAs in esophageal squamous cell cancer (ESCC) remains unclear. Materials & methods: Here we profiled six pair plasma circRNA in ESCC based on RNA sequencing, and then verified the elevation of hsa_circ_0004771 in 20 cancer tissues and 105 pair case-control plasma samples by quantitative reverse t...

journal_title：Epigenomics

authors： Huang E,Fu J,Yu Q,Xie P,Yang Z,Ji H,Wang L,Luo G,Zhang Y,Li K

更新日期：2020-04-01 00:00:00

abstract：AIMS:To investigate if DNA methylation pattern assay could be a new approach to identifying the primary tumor cell origin of the recurrent hepatocellular carcinoma (HCC). MATERIALS & METHODS:Methylation of 24 genes and expression of 22 cancer stem cell (CSC) biomarkers were quantitatively measured in 10 paired primary...

journal_title：Epigenomics

authors： Zhang X,Liu S,Shen C,Wu Y,Zhang L,Chen X,Lu F

更新日期：2015-01-01 00:00:00

abstract：:Aim: Myotonic dystrophy type 1 (DM1) is caused by an unstable trinucleotide (CTG) expansion at the DMPK gene locus. Cognitive dysfunctions are often observed in the condition. We investigated the association between DMPK blood DNA methylation (DNAm) and cognitive functions in DM1, considering expansion length and vari...

journal_title：Epigenomics

authors： Breton É,Légaré C,Overend G,Guay SP,Monckton D,Mathieu J,Gagnon C,Richer L,Gallais B,Bouchard L

更新日期：2020-12-01 00:00:00