A role for microRNAs in the epigenetic control of sexually dimorphic gene expression in the human placenta.

Abstract:

:Aim: The contribution of miRNAs as epigenetic regulators of sexually dimorphic gene expression in the placenta is unknown. Materials & methods: 382 placentas from the extremely low gestational age newborns (ELGAN) cohort were evaluated for expression levels of 37,268 mRNAs and 2,102 miRNAs using genome-wide RNA-sequencing. Differential expression analysis was used to identify differences in the expression based on the sex of the fetus. Results: Sexually dimorphic expression was observed for 128 mRNAs and 59 miRNAs. A set of 25 miRNA master regulators was identified that likely contribute to the sexual dimorphic mRNA expression. Conclusion: These data highlight sex-dependent miRNA and mRNA patterning in the placenta and provide insight into a potential mechanism for observed sex differences in outcomes.

journal_name

Epigenomics

journal_title

Epigenomics

authors

Eaves LA,Phookphan P,Rager JE,Bangma J,Santos HP Jr,Smeester L,O'Shea TM,Fry RC

doi

10.2217/epi-2020-0062

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

1543-1558

issue

17

eissn

1750-1911

issn

1750-192X

journal_volume

12

pub_type

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