DNA methylation consistency implicates the primary tumor cell origin of recurrent hepatocellular carcinoma.

abstract：:This article focuses on the epigenetic alterations of aberrant promoter hypermethylation of genes, and histone modifications or RNA interference in cancer cells. Current knowledge of the hypermethylation of allele(s) in classical tumor suppressor genes in inherited and sporadic cancer, candidate tumor suppressor and o...

journal_title：Epigenomics

authors： Hoffman AM,Cairns P

更新日期：2011-02-01 00:00:00

abstract：:Prostate cancer is the most common cancer in men and the second leading cause of cancer deaths in men in France. Apart from the genetic alterations in prostate cancer, epigenetics modifications are involved in the development and progression of this disease. Epigenetic events are the main cause in gene regulation and ...

journal_title：Epigenomics

authors： Ngollo M,Dagdemir A,Karsli-Ceppioglu S,Judes G,Pajon A,Penault-Llorca F,Boiteux JP,Bignon YJ,Guy L,Bernard-Gallon DJ

更新日期：2014-01-01 00:00:00

abstract：AIM:To characterize the genotypic and phenotypic extent of multilocus imprinting disturbances (MLID). MATERIALS & METHODS:We analyzed 37 patients with imprinting disorders (explorative cohort) for DNA methylation changes using the Infinium HumanMethylation450 BeadChip. For validation, three independent cohorts with im...

journal_title：Epigenomics

authors： Bens S,Kolarova J,Beygo J,Buiting K,Caliebe A,Eggermann T,Gillessen-Kaesbach G,Prawitt D,Thiele-Schmitz S,Begemann M,Enklaar T,Gutwein J,Haake A,Paul U,Richter J,Soellner L,Vater I,Monk D,Horsthemke B,Ammerpohl O,

更新日期：2016-06-01 00:00:00

abstract：:Aberrant epigenomic programming is a hallmark of acute myeloid leukemia. This is partially due to somatic mutations that perturb cytosine methylation, histone post-translational modifications and transcription factors. Remarkably, mutations in the IDH1 and IDH2 genes perturb the epigenome through all three of these me...

journal_title：Epigenomics

authors： Garrett-Bakelman FE,Melnick AM

更新日期：2016-07-01 00:00:00

abstract：:Protein methyltransferases (PMT)s play essential roles in many biological processes through methylation of histones and diverse nonhistone substrates. Dysregulation of these enzymes has been implicated in many diseases including cancers. While PMT-associated biology can be probed via genetic perturbation, this approac...

journal_title：Epigenomics

authors： Luo M

更新日期：2015-01-01 00:00:00

abstract：AIM:To develop a reliable method for whole genome analysis of DNA methylation. MATERIALS & METHODS:Genome-scale analysis of DNA methylation includes affinity-based approaches such as enrichment using methyl-CpG-binding proteins. One of these methods, the methylated-CpG island recovery assay (MIRA), is based on the hig...

journal_title：Epigenomics

authors： Jung M,Kadam S,Xiong W,Rauch TA,Jin SG,Pfeifer GP

更新日期：2015-08-01 00:00:00

abstract：:Stephen B Baylin is a codirector of the Cancer Biology Program at The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and the Virginia and DK Ludwig Professor of Oncology and Medicine. Baylin attended Duke University, where he earned his medical degree and completed his internship and first year residency i...

journal_title：Epigenomics

authors： Baylin SB

更新日期：2015-01-01 00:00:00

abstract：:Aim: We aimed to explore the roles of noncoding RNAs (ncRNAs) in renal cell carcinoma. Materials & methods: The altered expressions of miR-196a2, miR-499a, H19, MALAT1 and GAS5, as well as some target transcripts were identified by quantitative real-time reverse transcription polymerase chain reaction. Results: Up-reg...

journal_title：Epigenomics

authors： Fawzy MS,Toraih EA,Ageeli EA,Al-Qahtanie SA,Hussein MH,Kandil E

更新日期：2020-02-01 00:00:00

abstract：:Hematopoiesis is a regulated multistep process, whereby transcriptional and epigenetic events contribute to progenitor fate determination. miRNAs have emerged as key players in hematopoietic cell development, differentiation and malignant transformation. From embryonic development through to adult life, miRNAs coopera...

journal_title：Epigenomics

authors： Pagano F,De Marinis E,Grignani F,Nervi C

更新日期：2013-01-01 00:00:00

abstract：:Aim: This study aims to examine the DNA methylation (DNAm) and expression patterns of genes associated with placental angiogenesis in preeclampsia. Materials & methods: DNAm and expression were examined in normotensive (n = 100) and preeclampsia (n = 100) women using pyrosequencing and quantitative real-time PCR respe...

journal_title：Epigenomics

authors： M Dave K,Kaur L,Randhir KN,Mehendale SS,Sundrani DP,Chandak GR,Joshi SR

更新日期：2021-01-20 00:00:00

abstract：:Histone modifications regulate the structural status of chromatin and thereby influence the transcriptional status of genes. These processes are controlled by the recruitment of different enzymes to a specific genomic site. Furthermore, obtaining an understanding of these mechanisms could help delineate alternative tr...

journal_title：Epigenomics

authors： Calcagno DQ,Wisnieski F,Mota ERDS,Maia de Sousa SB,Costa da Silva JM,Leal MF,Gigek CO,Santos LC,Rasmussen LT,Assumpção PP,Burbano RR,Smith MA

更新日期：2019-02-01 00:00:00

abstract：:Sepsis is a life-threatening condition that occurs when the body responds to an infection damaging its own tissues. Sepsis survivors sometimes suffer from immunosuppression increasing the risk of death. To our best knowledge, there is no 'gold standard' for defining immunosuppression except for a composite clinical en...

journal_title：Epigenomics

authors： Beltrán-García J,Osca-Verdegal R,Romá-Mateo C,Carbonell N,Ferreres J,Rodríguez M,Mulet S,García-López E,Pallardó FV,García-Giménez JL

更新日期：2020-04-01 00:00:00

abstract：:Fundamental aspects of mammalian brain evolution occurred in the context of viviparity and placentation brought about by the epigenetic regulation of imprinted genes. Since the fetal placenta hormonally primes the maternal brain, two genomes in one individual are transgenerationally co-adapted to ensure maternal care ...

journal_title：Epigenomics

authors： Keverne EB

更新日期：2011-04-01 00:00:00

abstract：:Aim: This study aimed to identify novel miRNAs (miRs) as regulators of UGT1A gene expression and to evaluate them as potential risk factors for the development of liver fibrosis/cirrhosis. Materials & methods: miRNA target sites in UDP-glucuronosyltransferase 1A (UGT1A) 3'-UTR were predicted and confirmed by luciferas...

journal_title：Epigenomics

authors： Paulusch S,Kalthoff S,Landerer S,Jansen C,Schierwagen R,Klein S,Trebicka J,Strassburg CP

更新日期：2021-01-12 00:00:00

abstract：AIM:To investigate epigenomic changes in pregnancy and early postpartum in women with and without type 2 diabetes. METHODS:Dimethylation of histones H3K4, H3K9, H3K27, H3K36 and H3K79 was measured in white blood cells of women at 30 weeks pregnancy, at 8-10 and 20 weeks postpartum and in never-pregnant women. RESULTS...

journal_title：Epigenomics

authors： Michalczyk AA,Janus ED,Judge A,Ebeling PR,Best JD,Ackland MJ,Asproloupos D,Dunbar JA,Ackland ML

更新日期：2018-04-01 00:00:00

abstract：:For the first time, the development of next-generation sequencing technologies has brought about tools to investigate epigenetic alterations in an unbiased, yet genome-wide approach. The importance of this innovative technology is undeniable since it has already been established that changes in DNA methylation play an...

journal_title：Epigenomics

authors： Boerno ST,Grimm C,Lehrach H,Schweiger MR

更新日期：2010-04-01 00:00:00

abstract：:Aim: We examined methylation changes in cell-free DNA (cfDNA) in metastatic castration-resistant prostate cancer (mCRPC) during treatment. Patients & methods: Genome-wide methylation analysis of sequentially collected cfDNA samples derived from mCRPC patients undergoing androgen-targeting therapy was performed. Result...

journal_title：Epigenomics

authors： Peter MR,Bilenky M,Isserlin R,Bader GD,Shen SY,De Carvalho DD,Hansen AR,Hu P,Fleshner NE,Joshua AM,Hirst M,Bapat B

更新日期：2020-08-01 00:00:00

abstract：:This study aimed to unveil the functional roles of LINC00221 in hepatocellular carcinoma (HCC). A discovery cohort and a validation cohort were respectively used to identify and verify the clinical value of LINC00221 in HCC. Bioinformatics analysis was performed to explore its potential mechanisms. LINC00221 was upreg...

journal_title：Epigenomics

authors： Feng Y,Dramani Maman ST,Zhu X,Liu X,Bongolo CC,Liang C,Tu J

更新日期：2021-01-07 00:00:00

abstract：:Aim: To develop a method for estimating cell-specific effects in epigenomic association studies in the presence of cell type heterogeneity. Materials & methods: We utilized Monte Carlo Expectation-Maximization (MCEM) algorithm with Metropolis-Hastings sampler to reconstruct the 'missing' cell-specific methylations and...

journal_title：Epigenomics

authors： Feng YA,Guo Y,Pain L,Lathrop GM,Laprise C,Moffatt MF,Cookson WO,Liang L

更新日期：2020-12-22 00:00:00

abstract：AIM:There is a growing concern about the potential adverse effects of high dose folic acid (FA) supplementation before and during pregnancy. FA metabolism generates S-adenosyl methionine (SAM) which is an important cofactor of epigenetic programming. We sought to assess the impact of a large dose of SAM on early embryo...

journal_title：Epigenomics

authors： Shojaei Saadi HA,Gagné D,Fournier É,Baldoceda Baldeon LM,Sirard MA,Robert C

更新日期：2016-08-01 00:00:00

abstract：:Until recently, drug development in oncology was focused on treating most patients for a specific cancer type without taking in account the heterogeneity between these patients in term of response to treatment. Therefore, this type of broad treatment approach excludes the treatment of patient not responding to disease...

journal_title：Epigenomics

authors： Cartron PF,Cheray M,Bretaudeau L

更新日期：2020-01-01 00:00:00

abstract：:Aim: The goal of this study was to comprehensively interrogate and map DNA methylation across 16 CpG-dense regions previously associated with oral and pharyngeal squamous cell carcinoma (OPSCC). Materials & methods: Targeted multiplex bisulfite amplicon sequencing was performed on four OPSCC cell lines and primary non...

journal_title：Epigenomics

authors： Langevin SM,Kuhnell D,Niu L,Biesiada J,Leung YK,Deka R,Chen A,Medvedovic M,Kelsey KT,Kasper S,Zhang X

更新日期：2019-07-01 00:00:00

abstract：:The GTC Cancer Summit: Novel Approaches to Drug Discovery was divided into two parallel tracks: the 2nd Cancer Epigenetics Conference, and the Protein Kinases and Drug Design Conference. The 2nd Cancer Epigenetics Conference focused on exciting changes in drug discovery that include an unprecedented private and public...

journal_title：Epigenomics

authors： Smith CL

更新日期：2013-04-01 00:00:00

abstract：:Aim: Epilepsy is a common neurological disorder characterized by recurrent seizures. We performed epigenetic analyses between and within 15 monozygotic (MZ) twin pairs discordant for focal or generalized epilepsy. Methods: DNA methylation analysis was performed using Illumina Infinium MethylationEPIC arrays, in blood ...

journal_title：Epigenomics

authors： Mohandas N,Loke YJ,Hopkins S,Mackenzie L,Bennett C,Berkovic SF,Vadlamudi L,Craig JM

更新日期：2019-06-01 00:00:00

abstract：:A striking feature of mammalian genomes is the paucity of the CG dinucleotide. There are approximately 20,000 regions termed CpG islands where CGs cluster. This represents 5% of all CGs and 1% of the genome. CpG islands are typically unmethylated and are often promoters for housekeeping genes. The remaining 95% of CG ...

journal_title：Epigenomics

authors： Vinson C,Chatterjee R

更新日期：2012-12-01 00:00:00

abstract：AIM:To identify differentially methylated probes (DMPs) and regions (DMRs) in relation to chronic obstructive pulmonary disease (COPD) and lung function traits. METHODS:We performed an epigenome-wide association study of COPD and spirometric parameters, including forced expiratory volume in 1 s (FEV1), forced vital ca...

journal_title：Epigenomics

authors： Lee MK,Hong Y,Kim SY,Kim WJ,London SJ

更新日期：2017-07-01 00:00:00

abstract：:Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is widely used for mapping histone modifications, histone proteins, chromatin regulators, transcription factors and other DNA-binding proteins. It has played a significant role in our understanding of disease mechanisms and in exploring epigenetic changes...

journal_title：Epigenomics

authors： Yan H,Tian S,Slager SL,Sun Z

更新日期：2016-09-01 00:00:00

abstract：:Imprinted genes are an epigenetically regulated class of genes that are preferentially expressed from one parental allele. A number of these genes are crucial for placental function and embryonic growth in mice and humans. Disruption of imprinted genes is also associated with several neurodevelopmental disorders, alth...

journal_title：Epigenomics

authors： Kernohan KD,Bérubé NG

更新日期：2010-12-01 00:00:00

abstract：:Epigenetic modifications established during gametogenesis regulate transcription and other nuclear processes in gametes, but also have influences in the zygote, embryo and postnatal life. This is best understood for DNA methylation which, established at discrete regions of the oocyte and sperm genomes, governs genomic...

journal_title：Epigenomics

authors： Stewart KR,Veselovska L,Kelsey G

更新日期：2016-10-01 00:00:00

abstract：:Prader-Willi syndrome (PWS) is a relatively rare disorder that originates from paternally inherited deletions and maternal disomy (mUPD) within the 15q11-q13 region or alterations in the PWS imprinting center. Evidence is accumulating that mUPD underlies high prevalence of psychosis among PWS patients. Several genes i...

journal_title：Epigenomics

authors： Krefft M,Frydecka D,Adamowski T,Misiak B

更新日期：2014-01-01 00:00:00