Abstract:
:The examination of potential roles of epigenetic alterations in the pathogenesis of psychotic diseases have become an essential alternative in recent years as genetic studies alone are yet to uncover major gene(s) for psychosis. Here, we describe the current state of knowledge from the gene-specific and genome-wide studies of postmortem brain and blood cells indicating that aberrant DNA methylation, histone modifications and dysregulation of micro-RNAs are linked to the pathogenesis of mental diseases. There is also strong evidence supporting that all classes of psychiatric drugs modulate diverse features of the epigenome. While comprehensive environmental and genetic/epigenetic studies are uncovering the origins, and the key genes/pathways affected in psychotic diseases, characterizing the epigenetic effects of psychiatric drugs may help to design novel therapies in psychiatry.
journal_name
Epigenomicsjournal_title
Epigenomicsauthors
Abdolmaleky HM,Zhou JR,Thiagalingam Sdoi
10.2217/epi.14.85subject
Has Abstractpub_date
2015-01-01 00:00:00pages
427-49issue
3eissn
1750-1911issn
1750-192Xjournal_volume
7pub_type
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