Sex-specific histone modifications in mouse fetal and neonatal germ cells.

abstract：:Despite recent advances in therapy, subgroups of multiple myeloma continue to have a poor prognosis. Numerous epigenetic changes have been described and occur as both etiologic and secondary events, making myeloma a good disease in which to understand the role of epigenetic therapies. Here, we describe a number of cur...

journal_title：Epigenomics

authors： Pawlyn C,Kaiser MF,Davies FE,Morgan GJ

更新日期：2014-04-01 00:00:00

abstract：AIM:Disclosing the mechanisms that regulate reprogramming memory. MATERIALS & METHODS:We established computational procedure to find DNA methylation somatic memory sites (SMSs) at single CpGs and integrated them with genomics, epigenomics, transcriptomics and imprinting information. RESULTS & CONCLUSION:Reprogramming...

journal_title：Epigenomics

authors： Luu PL,Gerovska D,Schöler HR,Araúzo-Bravo MJ

更新日期：2018-02-01 00:00:00

abstract：:Aim: The contribution of miRNAs as epigenetic regulators of sexually dimorphic gene expression in the placenta is unknown. Materials & methods: 382 placentas from the extremely low gestational age newborns (ELGAN) cohort were evaluated for expression levels of 37,268 mRNAs and 2,102 miRNAs using genome-wide RNA-sequen...

journal_title：Epigenomics

authors： Eaves LA,Phookphan P,Rager JE,Bangma J,Santos HP Jr,Smeester L,O'Shea TM,Fry RC

更新日期：2020-09-01 00:00:00

abstract：AIM:Aberrant epigenetic events are important contributors to the pathogenesis of different types of cancers and dietary botanicals with epigenetic properties can influence early cancer development leading to cancer prevention effects. We sought to investigate potential combinatorial effects of bioactive dietary compone...

journal_title：Epigenomics

authors： Li Y,Buckhaults P,Cui X,Tollefsbol TO

更新日期：2016-08-01 00:00:00

abstract：:The E3 ubiquitin ligase UBE3A, also known as E6-AP, has a multitude of ascribed functions and targets relevant to human health and disease. Epigenetic regulation of the UBE3A gene by parentally imprinted noncoding transcription within human chromosome 15q11.2-q13.3 is responsible for the maternal-specific effects of 1...

journal_title：Epigenomics

authors： LaSalle JM,Reiter LT,Chamberlain SJ

更新日期：2015-10-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a complex lung disease of unknown etiology. Development of IPF is influenced by both genetic and environmental factors. Gene-expression profiling studies have taught us quite a bit about the biology of this fatal disease, but epigenetic marks may be the missing link that connects...

journal_title：Epigenomics

authors： Yang IV

更新日期：2012-04-01 00:00:00

abstract：AIM:This study aims to couple DNA methylation changes and evolution of retrogenes. MATERIALS & METHODS:A new two-step strategy was developed to screen retrogenes. Further, reduced representation bisulfite sequencing and RNA-seq data of eight tissues were used to analyze retrogenes. RESULTS:A total of 964 retrocopies ...

journal_title：Epigenomics

authors： Fang C,Zou C,Fu Y,Li J,Li Y,Ma Y,Zhao S,Li C

更新日期：2018-02-01 00:00:00

abstract：:Aim: We aimed to explore the roles of noncoding RNAs (ncRNAs) in renal cell carcinoma. Materials & methods: The altered expressions of miR-196a2, miR-499a, H19, MALAT1 and GAS5, as well as some target transcripts were identified by quantitative real-time reverse transcription polymerase chain reaction. Results: Up-reg...

journal_title：Epigenomics

authors： Fawzy MS,Toraih EA,Ageeli EA,Al-Qahtanie SA,Hussein MH,Kandil E

更新日期：2020-02-01 00:00:00

abstract：:Aim: To determine changes in global DNA methylation in monocytes from neonates of women with obesity, as markers of an immune programming resulting from maternal obesity. Materials & methods: Cord blood monocytes were obtained from neonates born to women with obesity and normal weight, genome-wide differentially methy...

journal_title：Epigenomics

authors： Vega-Tapia F,Artigas R,Hernández C,Uauy R,Casanello P,Krause BJ,Castro-Rodriguez JA

更新日期：2020-11-01 00:00:00

abstract：AIM:To assess the associations between gestational diabetes mellitus (GDM) and DNA methylation levels at genes related to energy metabolism. PATIENTS & METHODS:Ten loci were selected from our recent epigenome-wide association study on GDM. DNA methylation levels were quantified by bisulfite pyrosequencing in 80 placen...

journal_title：Epigenomics

authors： Houde AA,Ruchat SM,Allard C,Baillargeon JP,St-Pierre J,Perron P,Gaudet D,Brisson D,Hivert MF,Bouchard L

更新日期：2015-10-01 00:00:00

abstract：:The examination of potential roles of epigenetic alterations in the pathogenesis of psychotic diseases have become an essential alternative in recent years as genetic studies alone are yet to uncover major gene(s) for psychosis. Here, we describe the current state of knowledge from the gene-specific and genome-wide st...

journal_title：Epigenomics

authors： Abdolmaleky HM,Zhou JR,Thiagalingam S

更新日期：2015-01-01 00:00:00

abstract：:Aim: The role of circRNAs in esophageal squamous cell cancer (ESCC) remains unclear. Materials & methods: Here we profiled six pair plasma circRNA in ESCC based on RNA sequencing, and then verified the elevation of hsa_circ_0004771 in 20 cancer tissues and 105 pair case-control plasma samples by quantitative reverse t...

journal_title：Epigenomics

authors： Huang E,Fu J,Yu Q,Xie P,Yang Z,Ji H,Wang L,Luo G,Zhang Y,Li K

更新日期：2020-04-01 00:00:00

abstract：:This study aimed to unveil the functional roles of LINC00221 in hepatocellular carcinoma (HCC). A discovery cohort and a validation cohort were respectively used to identify and verify the clinical value of LINC00221 in HCC. Bioinformatics analysis was performed to explore its potential mechanisms. LINC00221 was upreg...

journal_title：Epigenomics

authors： Feng Y,Dramani Maman ST,Zhu X,Liu X,Bongolo CC,Liang C,Tu J

更新日期：2021-01-07 00:00:00

abstract：:For the first time, the development of next-generation sequencing technologies has brought about tools to investigate epigenetic alterations in an unbiased, yet genome-wide approach. The importance of this innovative technology is undeniable since it has already been established that changes in DNA methylation play an...

journal_title：Epigenomics

authors： Boerno ST,Grimm C,Lehrach H,Schweiger MR

更新日期：2010-04-01 00:00:00

abstract：:A number of bioactive dietary components are of particular interest in the field of epigenetics. Many of these compounds display anticancer properties and may play a role in cancer prevention. Numerous studies suggest that a number of nutritional compounds have epigenetic targets in cancer cells. Importantly, emerging...

journal_title：Epigenomics

authors： Hardy TM,Tollefsbol TO

更新日期：2011-08-01 00:00:00

abstract：:Post-translational modifications of chromatin have become a 'booming' area of biomedical research. One particularly interesting modification that is important for eukaryotic gene expression is trimethylation of histone H3 lysine 4 (H3K4me3), which is almost exclusively associated with active promoters of RNA polymeras...

journal_title：Epigenomics

authors： Vermeulen M,Timmers HT

更新日期：2010-06-01 00:00:00

abstract：:Asthma is a chronic disease which causes recurrent breathlessness affecting 300 million people worldwide of whom 250,000 die annually. The epigenome is a set of heritable modifications and tags that affect the genome without changing the intrinsic DNA sequence. These marks include DNA methylation, modifications to his...

journal_title：Epigenomics

authors： Brook PO,Perry MM,Adcock IM,Durham AL

更新日期：2015-01-01 00:00:00

abstract：AIM:To identify regions of aberrant DNA methylation in acute lymphoblastic leukemia (ALL) cells of different subtypes on a genome-wide scale. MATERIALS & METHODS:Whole-genome bisulfite sequencing (WGBS) was used to determine the DNA methylation levels in cells from four pediatric ALL patients of different subtypes. Th...

journal_title：Epigenomics

authors： Wahlberg P,Lundmark A,Nordlund J,Busche S,Raine A,Tandre K,Rönnblom L,Sinnett D,Forestier E,Pastinen T,Lönnerholm G,Syvänen AC

更新日期：2016-10-01 00:00:00

abstract：:Epigenetic modifications established during gametogenesis regulate transcription and other nuclear processes in gametes, but also have influences in the zygote, embryo and postnatal life. This is best understood for DNA methylation which, established at discrete regions of the oocyte and sperm genomes, governs genomic...

journal_title：Epigenomics

authors： Stewart KR,Veselovska L,Kelsey G

更新日期：2016-10-01 00:00:00

abstract：AIM:To identify DNA methylation biomarkers in peripheral blood samples from triple-negative breast cancer (TNBC) patients. MATERIALS & METHODS:We conducted an epigenome-wide association study (EWAS): the most promising markers were identified in 233 TNBC case-control pairs (discovery set) and subsequently validated in...

journal_title：Epigenomics

authors： Bermejo JL,Huang G,Manoochehri M,Mesa KG,Schick M,Silos RG,Ko YD,Brüning T,Brauch H,Lo WY,Hoheisel JD,Hamann U

更新日期：2019-01-01 00:00:00

abstract：AIM:The aim was to investigate the effect of miR-377 on DNMT1 expression and cancer phenotype in pancreatic cancer cells. MATERIALS & METHODS:Real-time PCR, luciferase assay, MTT and Annexin-PI staining were used. RESULTS:Decreased miR-377 and increased DNMT1 (verified as a target for mir-377) levels in pancreatic ca...

journal_title：Epigenomics

authors： Azizi M,Fard-Esfahani P,Mahmoodzadeh H,Fazeli MS,Azadmanesh K,Zeinali S,Teimoori-Toolabi L

更新日期：2017-08-01 00:00:00

abstract：:Aim: To develop a method for estimating cell-specific effects in epigenomic association studies in the presence of cell type heterogeneity. Materials & methods: We utilized Monte Carlo Expectation-Maximization (MCEM) algorithm with Metropolis-Hastings sampler to reconstruct the 'missing' cell-specific methylations and...

journal_title：Epigenomics

authors： Feng YA,Guo Y,Pain L,Lathrop GM,Laprise C,Moffatt MF,Cookson WO,Liang L

更新日期：2020-12-22 00:00:00

abstract：:Manipulation of chromatin, in which genomic DNA is packaged, is a fundamental requirement for all DNA-based metabolic processes in eukayotic cells. Histone variant incorporation, histone post-translational modifications, and ATP-dependent chromatin remodeling are three major strategies for chromatin manipulation, and ...

journal_title：Epigenomics

authors： Bao Y

更新日期：2011-06-01 00:00:00

abstract：AIM:We examined maternal prepregnancy anthropometry and cord blood DNA methylation. METHODS:Associations between maternal measures (i.e., weight, height, waist circumference, hip circumference, skinfolds, leptin) and methylation β-values at each CpG (measured by the Infinium MethylationEPIC BeadChip) were estimated am...

journal_title：Epigenomics

authors： Yeung EH,Guan W,Mumford SL,Silver RM,Zhang C,Tsai MY,Schisterman EF

更新日期：2019-02-01 00:00:00

abstract：:Arsenic is a nonmutagenic human carcinogen that induces tumors through unknown mechanisms. A growing body of evidence suggests that its carcinogenicity results from epigenetic changes, particularly in DNA methylation. Changes in gene methylation status, mediated by arsenic, have been proposed to activate oncogene expr...

journal_title：Epigenomics

authors： Reichard JF,Puga A

更新日期：2010-02-01 00:00:00

abstract：AIM:To assess the correlation between KDM6B and estrogen receptor β (ERβ) expression in malignant pleural mesothelioma (MPM). MATERIALS & METHODS:We evaluated gene expression by in silico analysis of microarray data, real-time PCR and western blot in MPM tumors and cell lines. RESULTS & CONCLUSION:We report a strong ...

journal_title：Epigenomics

authors： Manente AG,Pinton G,Zonca S,Tavian D,Habib T,Jithesh PV,Fennell D,Nilsson S,Moro L

更新日期：2016-09-01 00:00:00

abstract：:Aim: We examined methylation changes in cell-free DNA (cfDNA) in metastatic castration-resistant prostate cancer (mCRPC) during treatment. Patients & methods: Genome-wide methylation analysis of sequentially collected cfDNA samples derived from mCRPC patients undergoing androgen-targeting therapy was performed. Result...

journal_title：Epigenomics

authors： Peter MR,Bilenky M,Isserlin R,Bader GD,Shen SY,De Carvalho DD,Hansen AR,Hu P,Fleshner NE,Joshua AM,Hirst M,Bapat B

更新日期：2020-08-01 00:00:00

abstract：:Aim: To uncover a novel lncRNA-miRNA-mRNA network associated with high-grade serous ovarian cancer metastasis. Material & methods: The candidate differentially expressed lncRNAs were obtained from RNA-sequencing data and determined by functional experiments. The downstream miRNAs and mRNAs were identified by bioinform...

journal_title：Epigenomics

authors： Li X,Yu S,Yang R,Wang Q,Liu X,Ma M,Li Y,Wu S

更新日期：2020-07-01 00:00:00

abstract：AIM:To characterize the genotypic and phenotypic extent of multilocus imprinting disturbances (MLID). MATERIALS & METHODS:We analyzed 37 patients with imprinting disorders (explorative cohort) for DNA methylation changes using the Infinium HumanMethylation450 BeadChip. For validation, three independent cohorts with im...

journal_title：Epigenomics

authors： Bens S,Kolarova J,Beygo J,Buiting K,Caliebe A,Eggermann T,Gillessen-Kaesbach G,Prawitt D,Thiele-Schmitz S,Begemann M,Enklaar T,Gutwein J,Haake A,Paul U,Richter J,Soellner L,Vater I,Monk D,Horsthemke B,Ammerpohl O,

更新日期：2016-06-01 00:00:00

abstract：:Background: Castration-resistant prostate cancer (CRPC) is an incurable malignancy. Long noncoding RNAs (lncRNAs) play key roles in drug resistance. Materials & methods: LncRNA HORAS5 role in cabazitaxel resistance (i.e., cell-count, IC50 and caspase activity) was studied via lentiviral-mediated overexpression and siR...

journal_title：Epigenomics

authors： Pucci P,Venalainen E,Alborelli I,Quagliata L,Hawkes C,Mather R,Romero I,Rigas SH,Wang Y,Crea F

更新日期：2020-07-01 00:00:00