Role of histone acetylation in gastric cancer: implications of dietetic compounds and clinical perspectives.

abstract：:Cancer numbers increasing, cases heterogeneity and the drug resistance emergence have pushed scientists to search for innovative solutions for patients and epimutations can be one. Methylated DNA, modified nucleosomes and noncoding RNAs are found in all cells, including tumor cells. They are intracellular actors but a...

journal_title：Epigenomics

authors： Duforestel M,Briand J,Bougras-Cartron G,Heymann D,Frenel JS,Vallette FM,Cartron PF

更新日期：2020-01-01 00:00:00

abstract：:Sepsis is a life-threatening condition that occurs when the body responds to an infection damaging its own tissues. Sepsis survivors sometimes suffer from immunosuppression increasing the risk of death. To our best knowledge, there is no 'gold standard' for defining immunosuppression except for a composite clinical en...

journal_title：Epigenomics

authors： Beltrán-García J,Osca-Verdegal R,Romá-Mateo C,Carbonell N,Ferreres J,Rodríguez M,Mulet S,García-López E,Pallardó FV,García-Giménez JL

更新日期：2020-04-01 00:00:00

abstract：:Alterations in DNA methylation have been associated with cognitive decline and Alzheimer's disease. A recent study of mild cognitive impairment (MCI) reported a significant association between annual decline in cognitive function and the rs11887120 SNP located in DNMT3A, a gene implicated in DNA methylation. Here, we ...

journal_title：Epigenomics

authors： Bey K,Wolfsgruber S,Karaca I,Wagner H,Lardenoije R,Becker J,Milz E,Kornhuber J,Peters O,Frölich L,Hüll M,Rüther E,Wiltfang J,Riedel-Heller S,Scherer M,Jessen F,Maier W,van den Hove DL,Rutten BP,Wagner M,Ramirez A

更新日期：2016-05-01 00:00:00

abstract：:The GTC Cancer Summit: Novel Approaches to Drug Discovery was divided into two parallel tracks: the 2nd Cancer Epigenetics Conference, and the Protein Kinases and Drug Design Conference. The 2nd Cancer Epigenetics Conference focused on exciting changes in drug discovery that include an unprecedented private and public...

journal_title：Epigenomics

authors： Smith CL

更新日期：2013-04-01 00:00:00

abstract：:Aim: To examine the impact of 4-nonylphenol (4-NP), on the expression of polycomb repressive complexes and cellular proliferation. Materials & methods: Cell proliferation assays, quantitative PCR, Western blotting, luciferase reporter assay, chromatin immunoprecipitation-quantitative PCR were used for the study. Resul...

journal_title：Epigenomics

authors： Ghosh K,Chatterjee B,Maheswari U,Athifa M,Kanade SR

更新日期：2019-06-01 00:00:00

abstract：:The widely accepted association between aberrant methylation at specific imprinted loci and distinct imprinting disorders has recently been brought into question by the identification of methylation defects at multiple loci (multilocus methylation defect [MLMD]). Strikingly, in different imprinting disorders, the same...

journal_title：Epigenomics

authors： Eggermann T,Leisten I,Binder G,Begemann M,Spengler S

更新日期：2011-10-01 00:00:00

abstract：AIM:Disclosing the mechanisms that regulate reprogramming memory. MATERIALS & METHODS:We established computational procedure to find DNA methylation somatic memory sites (SMSs) at single CpGs and integrated them with genomics, epigenomics, transcriptomics and imprinting information. RESULTS & CONCLUSION:Reprogramming...

journal_title：Epigenomics

authors： Luu PL,Gerovska D,Schöler HR,Araúzo-Bravo MJ

更新日期：2018-02-01 00:00:00

abstract：:Fibrosis is the excess deposition of extracellular matrix components which occur in multiple organs and ultimately leads to organ failure. Long noncoding RNAs (lncRNAs) are a kind of noncoding RNAs longer than approximately 200 nucleotides with no protein-encoding capacity. A growing body of evidence suggests that lnc...

journal_title：Epigenomics

authors： Jiang X,Zhang F

更新日期：2017-09-01 00:00:00

abstract：:Prostate cancer is the most common cancer in men and the second leading cause of cancer deaths in men in France. Apart from the genetic alterations in prostate cancer, epigenetics modifications are involved in the development and progression of this disease. Epigenetic events are the main cause in gene regulation and ...

journal_title：Epigenomics

authors： Ngollo M,Dagdemir A,Karsli-Ceppioglu S,Judes G,Pajon A,Penault-Llorca F,Boiteux JP,Bignon YJ,Guy L,Bernard-Gallon DJ

更新日期：2014-01-01 00:00:00

abstract：:Prader-Willi syndrome (PWS) is a relatively rare disorder that originates from paternally inherited deletions and maternal disomy (mUPD) within the 15q11-q13 region or alterations in the PWS imprinting center. Evidence is accumulating that mUPD underlies high prevalence of psychosis among PWS patients. Several genes i...

journal_title：Epigenomics

authors： Krefft M,Frydecka D,Adamowski T,Misiak B

更新日期：2014-01-01 00:00:00

abstract：:Protein methyltransferases (PMT)s play essential roles in many biological processes through methylation of histones and diverse nonhistone substrates. Dysregulation of these enzymes has been implicated in many diseases including cancers. While PMT-associated biology can be probed via genetic perturbation, this approac...

journal_title：Epigenomics

authors： Luo M

更新日期：2015-01-01 00:00:00

abstract：AIMS:To investigate if DNA methylation pattern assay could be a new approach to identifying the primary tumor cell origin of the recurrent hepatocellular carcinoma (HCC). MATERIALS & METHODS:Methylation of 24 genes and expression of 22 cancer stem cell (CSC) biomarkers were quantitatively measured in 10 paired primary...

journal_title：Epigenomics

authors： Zhang X,Liu S,Shen C,Wu Y,Zhang L,Chen X,Lu F

更新日期：2015-01-01 00:00:00

abstract：:Aim: To identify pregnancy-associated changes in cervical noncoding RNA (ncRNA), including miRNA and long noncoding RNA (lncRNA), and their potential effects on biologic processes. Materials & methods: We enrolled 21 pregnant women with term deliveries (≥37 weeks' gestation) in a prospective cohort and collected cervi...

journal_title：Epigenomics

authors： Gerson KD,Haviland MJ,Neo D,Hecht JL,Baccarelli AA,Brennan KJ,Dereix AE,Ralston SJ,Hacker MR,Burris HH

更新日期：2020-06-01 00:00:00

abstract：:Aim: Myotonic dystrophy type 1 (DM1) is caused by an unstable trinucleotide (CTG) expansion at the DMPK gene locus. Cognitive dysfunctions are often observed in the condition. We investigated the association between DMPK blood DNA methylation (DNAm) and cognitive functions in DM1, considering expansion length and vari...

journal_title：Epigenomics

authors： Breton É,Légaré C,Overend G,Guay SP,Monckton D,Mathieu J,Gagnon C,Richer L,Gallais B,Bouchard L

更新日期：2020-12-01 00:00:00

abstract：AIM:Imprinted genes exhibit expression in a parent-of-origin-dependent manner and are critical for child development. Recent limited evidence suggests that prenatal exposure to phthalates, ubiquitous endocrine disruptors, can affect their epigenetic dysregulation. MATERIALS & METHODS:We quantified DNA methylation of n...

journal_title：Epigenomics

authors： Tindula G,Murphy SK,Grenier C,Huang Z,Huen K,Escudero-Fung M,Bradman A,Eskenazi B,Hoyo C,Holland N

更新日期：2018-07-01 00:00:00

abstract：:There are numerous examples of enduring effects of early experience on gene transcription and neural function. We review the emerging evidence for epigenetics as a candidate mechanism for such effects. There is now evidence that intracellular signals activated by environmental events can directly modify the epigenetic...

journal_title：Epigenomics

authors： Sng J,Meaney MJ

更新日期：2009-10-01 00:00:00

abstract：:Stephen B Baylin is a codirector of the Cancer Biology Program at The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and the Virginia and DK Ludwig Professor of Oncology and Medicine. Baylin attended Duke University, where he earned his medical degree and completed his internship and first year residency i...

journal_title：Epigenomics

authors： Baylin SB

更新日期：2015-01-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a complex lung disease of unknown etiology. Development of IPF is influenced by both genetic and environmental factors. Gene-expression profiling studies have taught us quite a bit about the biology of this fatal disease, but epigenetic marks may be the missing link that connects...

journal_title：Epigenomics

authors： Yang IV

更新日期：2012-04-01 00:00:00

abstract：AIM:To assess the associations between gestational diabetes mellitus (GDM) and DNA methylation levels at genes related to energy metabolism. PATIENTS & METHODS:Ten loci were selected from our recent epigenome-wide association study on GDM. DNA methylation levels were quantified by bisulfite pyrosequencing in 80 placen...

journal_title：Epigenomics

authors： Houde AA,Ruchat SM,Allard C,Baillargeon JP,St-Pierre J,Perron P,Gaudet D,Brisson D,Hivert MF,Bouchard L

更新日期：2015-10-01 00:00:00

abstract：AIM:In nondividing neurons examine the role of Gadd45b in active 5-methylcytosine (5MC) and 5-hydroxymethylcytosine (5HMC) removal at a gene promoter highly implicated in mental illnesses and cognition, Bdnf. MATERIALS & METHODS:Mouse primary cortical neuronal cultures with and without Gadd45b siRNA transfection were ...

journal_title：Epigenomics

authors： Gavin DP,Kusumo H,Sharma RP,Guizzetti M,Guidotti A,Pandey SC

更新日期：2015-01-01 00:00:00

abstract：:A number of bioactive dietary components are of particular interest in the field of epigenetics. Many of these compounds display anticancer properties and may play a role in cancer prevention. Numerous studies suggest that a number of nutritional compounds have epigenetic targets in cancer cells. Importantly, emerging...

journal_title：Epigenomics

authors： Hardy TM,Tollefsbol TO

更新日期：2011-08-01 00:00:00

abstract：:Asthma is a chronic disease which causes recurrent breathlessness affecting 300 million people worldwide of whom 250,000 die annually. The epigenome is a set of heritable modifications and tags that affect the genome without changing the intrinsic DNA sequence. These marks include DNA methylation, modifications to his...

journal_title：Epigenomics

authors： Brook PO,Perry MM,Adcock IM,Durham AL

更新日期：2015-01-01 00:00:00

abstract：:This study aimed to unveil the functional roles of LINC00221 in hepatocellular carcinoma (HCC). A discovery cohort and a validation cohort were respectively used to identify and verify the clinical value of LINC00221 in HCC. Bioinformatics analysis was performed to explore its potential mechanisms. LINC00221 was upreg...

journal_title：Epigenomics

authors： Feng Y,Dramani Maman ST,Zhu X,Liu X,Bongolo CC,Liang C,Tu J

更新日期：2021-01-07 00:00:00

abstract：:Currently, the incidence of colorectal cancer (CRC) is increasing across the world. The cancer stroma exerts an impact on the spread, invasion and chemoresistance of CRC. The tumor microenvironment involves a complex interaction between cancer cells and stromal cells, for example, cancer-associated fibroblasts (CAFs)....

journal_title：Epigenomics

authors： Savardashtaki A,Shabaninejad Z,Movahedpour A,Sahebnasagh R,Mirzaei H,Hamblin MR

更新日期：2019-11-01 00:00:00

abstract：AIM:To characterize the genotypic and phenotypic extent of multilocus imprinting disturbances (MLID). MATERIALS & METHODS:We analyzed 37 patients with imprinting disorders (explorative cohort) for DNA methylation changes using the Infinium HumanMethylation450 BeadChip. For validation, three independent cohorts with im...

journal_title：Epigenomics

authors： Bens S,Kolarova J,Beygo J,Buiting K,Caliebe A,Eggermann T,Gillessen-Kaesbach G,Prawitt D,Thiele-Schmitz S,Begemann M,Enklaar T,Gutwein J,Haake A,Paul U,Richter J,Soellner L,Vater I,Monk D,Horsthemke B,Ammerpohl O,

更新日期：2016-06-01 00:00:00

abstract：:Epigenetic enzymes are emerging as crucial controllers of macrophages, innate immune cells that determine the outcome of many inflammatory diseases. Recent studies demonstrate that the activity of particular chromatin-modifying enzymes is regulated by the availability of specific metabolites like acetyl-coenzyme A, S-...

journal_title：Epigenomics

authors： Baardman J,Licht I,de Winther MP,Van den Bossche J

更新日期：2015-10-01 00:00:00

abstract：:The examination of potential roles of epigenetic alterations in the pathogenesis of psychotic diseases have become an essential alternative in recent years as genetic studies alone are yet to uncover major gene(s) for psychosis. Here, we describe the current state of knowledge from the gene-specific and genome-wide st...

journal_title：Epigenomics

authors： Abdolmaleky HM,Zhou JR,Thiagalingam S

更新日期：2015-01-01 00:00:00

abstract：:Histone deacetylase (HDAC)6 is a member of the class IIb HDAC family. This enzyme is zinc-dependent and mainly localized in the cytoplasm. HDAC6 is a unique isoenzyme with two functional catalytic domains and specific physiological roles. Indeed, HDAC6 deacetylates various substrates including α-tubulin and HSP90α, an...

journal_title：Epigenomics

authors： Seidel C,Schnekenburger M,Dicato M,Diederich M

更新日期：2015-01-01 00:00:00

abstract：AIM:In order to identify regulators of foam cells, we studied the H3K27 demethylase Kdm6b (also known as Jmjd3), a known regulator of macrophages, in controlling the transcriptional profile of foam cells. MATERIALS & METHODS:Foam cells from Kdm6b-deleted or Kdm6b wild-type mice were isolated and used for RNA-sequencin...

journal_title：Epigenomics

authors： Neele AE,Prange KH,Hoeksema MA,van der Velden S,Lucas T,Dimmeler S,Lutgens E,Van den Bossche J,de Winther MP

更新日期：2017-04-01 00:00:00

abstract：:The Medical Research Council Clinical Sciences Centre Symposium on Epigenetic Regulation: From Mechanism to Intervention in London, UK, which was held on 20-22 June 2012, attracted 305 participants from around the globe and included 37 speakers and 85 selected poster presentations. The organizing committee, led by Nia...

journal_title：Epigenomics

authors： Chatterjee A

更新日期：2012-10-01 00:00:00