Epigenetic biomarkers for human sepsis and septic shock: insights from immunosuppression.

Abstract:

:Sepsis is a life-threatening condition that occurs when the body responds to an infection damaging its own tissues. Sepsis survivors sometimes suffer from immunosuppression increasing the risk of death. To our best knowledge, there is no 'gold standard' for defining immunosuppression except for a composite clinical end point. As the immune system is exposed to epigenetic changes during and after sepsis, research that focuses on identifying new biomarkers to detect septic patients with immunoparalysis could offer new epigenetic-based strategies to predict short- and long-term pathological events related to this life-threatening state. This review describes the most relevant epigenetic mechanisms underlying alterations in the innate and adaptive immune responses described in sepsis and septic shock, and their consequences for immunosuppression states, providing several candidates to become epigenetic biomarkers that could improve sepsis management and help predict immunosuppression in postseptic patients.

journal_name

Epigenomics

journal_title

Epigenomics

authors

Beltrán-García J,Osca-Verdegal R,Romá-Mateo C,Carbonell N,Ferreres J,Rodríguez M,Mulet S,García-López E,Pallardó FV,García-Giménez JL

doi

10.2217/epi-2019-0329

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

617-646

issue

7

eissn

1750-1911

issn

1750-192X

journal_volume

12

pub_type

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