Abstract:
:Fibrosis is the excess deposition of extracellular matrix components which occur in multiple organs and ultimately leads to organ failure. Long noncoding RNAs (lncRNAs) are a kind of noncoding RNAs longer than approximately 200 nucleotides with no protein-encoding capacity. A growing body of evidence suggests that lncRNAs are also involved in tissues fibrosis in several organs, such as lungs fibrosis, liver fibrosis, renal fibrosis and cardiac fibrosis. In this review, we summarized the current studies of lncRNAs in the process of fibrosis and hopefully aid in better understanding the molecular mechanism of fibrosis and provide a basis to explore new therapeutic targets of fibrosis.
journal_name
Epigenomicsjournal_title
Epigenomicsauthors
Jiang X,Zhang Fdoi
10.2217/epi-2017-0020subject
Has Abstractpub_date
2017-09-01 00:00:00pages
1233-1241issue
9eissn
1750-1911issn
1750-192Xjournal_volume
9pub_type
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