Abstract:
AIM:Imprinted genes exhibit expression in a parent-of-origin-dependent manner and are critical for child development. Recent limited evidence suggests that prenatal exposure to phthalates, ubiquitous endocrine disruptors, can affect their epigenetic dysregulation. MATERIALS & METHODS:We quantified DNA methylation of nine imprinted gene differentially methylated regions by pyrosequencing in 296 cord blood DNA samples in a Mexican-American cohort. Fetal exposure was estimated by phthalate metabolite concentrations in maternal urine samples during pregnancy. RESULTS:Several differentially methylated regions of imprinted genes were associated with high molecular weight phthalates. The most consistent, positive, and false discovery rate significant associations were observed for MEG3. CONCLUSION:Phthalate exposure in utero may affect methylation status of imprinted genes in newborn children.
journal_name
Epigenomicsjournal_title
Epigenomicsauthors
Tindula G,Murphy SK,Grenier C,Huang Z,Huen K,Escudero-Fung M,Bradman A,Eskenazi B,Hoyo C,Holland Ndoi
10.2217/epi-2017-0178subject
Has Abstractpub_date
2018-07-01 00:00:00pages
1011-1026issue
7eissn
1750-1911issn
1750-192Xjournal_volume
10pub_type
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