Abstract:
:Children exposed to early-life adversity carry a greater risk of poor health and disease into adulthood. This increased disease risk is shadowed by changes in the epigenome. Epigenetics can change gene expression to modify disease risk; unfortunately, how epigenetics are changed by the environment is unclear. It is known that the environment modifies the microbiota, and recent data indicate that the microbiota and the epigenome interact and respond to each other. Specifically, the microbiome may alter the epigenome through the production of metabolites. Investigating the relationship between the microbiome and the epigenome may provide novel understanding of the impact of early-life environment on long-term health.
journal_name
Epigenomicsjournal_title
Epigenomicsauthors
Majnik AV,Lane RHdoi
10.2217/epi.15.74subject
Has Abstractpub_date
2015-10-01 00:00:00pages
1173-84issue
7eissn
1750-1911issn
1750-192Xjournal_volume
7pub_type
杂志文章,评审相关文献
Epigenomics文献大全abstract::Melanoma is a leading cause of death from cancers in the USA. While exposure to UV radiation has long been identified as a primary risk factor for melanoma, molecular mechanisms directly linking UV radiation to the development of melanoma, especially metastatic melanoma, are poorly understood. Besides abnormality in s...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.11.114
更新日期:2012-02-01 00:00:00
abstract:AIM:To show that an increased correlation between CpGs after selection through an epigenome-wide association studies (EWAS) might translate into biased replication results. METHODS:Pairwise correlation coefficients between CpGs selected in two published EWAS, the top hits replication, Bonferroni p-values, Benjamini-Ho...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2017-0073
更新日期:2017-12-01 00:00:00
abstract:AIM:Aberrant epigenetic events are important contributors to the pathogenesis of different types of cancers and dietary botanicals with epigenetic properties can influence early cancer development leading to cancer prevention effects. We sought to investigate potential combinatorial effects of bioactive dietary compone...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2016-0024
更新日期:2016-08-01 00:00:00
abstract::Aim: To examine the impact of 4-nonylphenol (4-NP), on the expression of polycomb repressive complexes and cellular proliferation. Materials & methods: Cell proliferation assays, quantitative PCR, Western blotting, luciferase reporter assay, chromatin immunoprecipitation-quantitative PCR were used for the study. Resul...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2018-0175
更新日期:2019-06-01 00:00:00
abstract::Aim: Epilepsy is a common neurological disorder characterized by recurrent seizures. We performed epigenetic analyses between and within 15 monozygotic (MZ) twin pairs discordant for focal or generalized epilepsy. Methods: DNA methylation analysis was performed using Illumina Infinium MethylationEPIC arrays, in blood ...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2018-0136
更新日期:2019-06-01 00:00:00
abstract::Aim: The contribution of miRNAs as epigenetic regulators of sexually dimorphic gene expression in the placenta is unknown. Materials & methods: 382 placentas from the extremely low gestational age newborns (ELGAN) cohort were evaluated for expression levels of 37,268 mRNAs and 2,102 miRNAs using genome-wide RNA-sequen...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2020-0062
更新日期:2020-09-01 00:00:00
abstract::Antisense RNA is the first noncoding RNA found to have a regulatory function. With the advances of biological science, it has been recognized that the function of antisense RNAs is not only limited to post-transcriptional regulation, but extends to transcriptional regulation of various important genes leading to epige...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.09.46
更新日期:2010-02-01 00:00:00
abstract::Idiopathic pulmonary fibrosis (IPF) is a complex lung disease of unknown etiology. Development of IPF is influenced by both genetic and environmental factors. Gene-expression profiling studies have taught us quite a bit about the biology of this fatal disease, but epigenetic marks may be the missing link that connects...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.12.10
更新日期:2012-04-01 00:00:00
abstract::The ability to culture pluripotent stem cells and direct their differentiation into specific cell types in vitro provides a valuable experimental system for modeling pluripotency, development and cellular differentiation. High-throughput profiling of the transcriptomes and epigenomes of pluripotent stem cells and thei...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.13.80
更新日期:2014-02-01 00:00:00
abstract::Aim: To dynamically analyze the differential m6A methylation during the progression and reversal of hepatic fibrosis. Materials & methods: We induced hepatic fibrosis in C57/BL6 mice by intraperitoneal injection of CCl4. The reversal model of hepatic fibrosis was established by stopping drug after continuous injection...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2019-0365
更新日期:2020-10-01 00:00:00
abstract:AIM:Disclosing the mechanisms that regulate reprogramming memory. MATERIALS & METHODS:We established computational procedure to find DNA methylation somatic memory sites (SMSs) at single CpGs and integrated them with genomics, epigenomics, transcriptomics and imprinting information. RESULTS & CONCLUSION:Reprogramming...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2017-0098
更新日期:2018-02-01 00:00:00
abstract::Aim: We aimed to explore the roles of noncoding RNAs (ncRNAs) in renal cell carcinoma. Materials & methods: The altered expressions of miR-196a2, miR-499a, H19, MALAT1 and GAS5, as well as some target transcripts were identified by quantitative real-time reverse transcription polymerase chain reaction. Results: Up-reg...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2019-0120
更新日期:2020-02-01 00:00:00
abstract::Aim: The goal of this study was to comprehensively interrogate and map DNA methylation across 16 CpG-dense regions previously associated with oral and pharyngeal squamous cell carcinoma (OPSCC). Materials & methods: Targeted multiplex bisulfite amplicon sequencing was performed on four OPSCC cell lines and primary non...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2018-0172
更新日期:2019-07-01 00:00:00
abstract::Aim: Myotonic dystrophy type 1 (DM1) is caused by an unstable trinucleotide (CTG) expansion at the DMPK gene locus. Cognitive dysfunctions are often observed in the condition. We investigated the association between DMPK blood DNA methylation (DNAm) and cognitive functions in DM1, considering expansion length and vari...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2020-0328
更新日期:2020-12-01 00:00:00
abstract::Manipulation of chromatin, in which genomic DNA is packaged, is a fundamental requirement for all DNA-based metabolic processes in eukayotic cells. Histone variant incorporation, histone post-translational modifications, and ATP-dependent chromatin remodeling are three major strategies for chromatin manipulation, and ...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.11.14
更新日期:2011-06-01 00:00:00
abstract::The widely accepted association between aberrant methylation at specific imprinted loci and distinct imprinting disorders has recently been brought into question by the identification of methylation defects at multiple loci (multilocus methylation defect [MLMD]). Strikingly, in different imprinting disorders, the same...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.11.84
更新日期:2011-10-01 00:00:00
abstract::The Medical Research Council Clinical Sciences Centre Symposium on Epigenetic Regulation: From Mechanism to Intervention in London, UK, which was held on 20-22 June 2012, attracted 305 participants from around the globe and included 37 speakers and 85 selected poster presentations. The organizing committee, led by Nia...
journal_title:Epigenomics
pub_type: 新闻
doi:10.2217/epi.12.47
更新日期:2012-10-01 00:00:00
abstract::Aim: The role of circRNAs in esophageal squamous cell cancer (ESCC) remains unclear. Materials & methods: Here we profiled six pair plasma circRNA in ESCC based on RNA sequencing, and then verified the elevation of hsa_circ_0004771 in 20 cancer tissues and 105 pair case-control plasma samples by quantitative reverse t...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2019-0404
更新日期:2020-04-01 00:00:00
abstract::The GTC Cancer Summit: Novel Approaches to Drug Discovery was divided into two parallel tracks: the 2nd Cancer Epigenetics Conference, and the Protein Kinases and Drug Design Conference. The 2nd Cancer Epigenetics Conference focused on exciting changes in drug discovery that include an unprecedented private and public...
journal_title:Epigenomics
pub_type:
doi:10.2217/epi.13.9
更新日期:2013-04-01 00:00:00
abstract::Prader-Willi syndrome (PWS) is a relatively rare disorder that originates from paternally inherited deletions and maternal disomy (mUPD) within the 15q11-q13 region or alterations in the PWS imprinting center. Evidence is accumulating that mUPD underlies high prevalence of psychosis among PWS patients. Several genes i...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.14.52
更新日期:2014-01-01 00:00:00
abstract::The examination of potential roles of epigenetic alterations in the pathogenesis of psychotic diseases have become an essential alternative in recent years as genetic studies alone are yet to uncover major gene(s) for psychosis. Here, we describe the current state of knowledge from the gene-specific and genome-wide st...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.14.85
更新日期:2015-01-01 00:00:00
abstract::Aim: To uncover a novel lncRNA-miRNA-mRNA network associated with high-grade serous ovarian cancer metastasis. Material & methods: The candidate differentially expressed lncRNAs were obtained from RNA-sequencing data and determined by functional experiments. The downstream miRNAs and mRNAs were identified by bioinform...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2020-0097
更新日期:2020-07-01 00:00:00
abstract:AIM:In nondividing neurons examine the role of Gadd45b in active 5-methylcytosine (5MC) and 5-hydroxymethylcytosine (5HMC) removal at a gene promoter highly implicated in mental illnesses and cognition, Bdnf. MATERIALS & METHODS:Mouse primary cortical neuronal cultures with and without Gadd45b siRNA transfection were ...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi.15.12
更新日期:2015-01-01 00:00:00
abstract:AIM:There is a growing concern about the potential adverse effects of high dose folic acid (FA) supplementation before and during pregnancy. FA metabolism generates S-adenosyl methionine (SAM) which is an important cofactor of epigenetic programming. We sought to assess the impact of a large dose of SAM on early embryo...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2016-0022
更新日期:2016-08-01 00:00:00
abstract::Fundamental aspects of mammalian brain evolution occurred in the context of viviparity and placentation brought about by the epigenetic regulation of imprinted genes. Since the fetal placenta hormonally primes the maternal brain, two genomes in one individual are transgenerationally co-adapted to ensure maternal care ...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.11.10
更新日期:2011-04-01 00:00:00
abstract:AIMS:To investigate if DNA methylation pattern assay could be a new approach to identifying the primary tumor cell origin of the recurrent hepatocellular carcinoma (HCC). MATERIALS & METHODS:Methylation of 24 genes and expression of 22 cancer stem cell (CSC) biomarkers were quantitatively measured in 10 paired primary...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi.15.23
更新日期:2015-01-01 00:00:00
abstract:AIM:In order to identify regulators of foam cells, we studied the H3K27 demethylase Kdm6b (also known as Jmjd3), a known regulator of macrophages, in controlling the transcriptional profile of foam cells. MATERIALS & METHODS:Foam cells from Kdm6b-deleted or Kdm6b wild-type mice were isolated and used for RNA-sequencin...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2016-0152
更新日期:2017-04-01 00:00:00
abstract::Epigenetic modifications established during gametogenesis regulate transcription and other nuclear processes in gametes, but also have influences in the zygote, embryo and postnatal life. This is best understood for DNA methylation which, established at discrete regions of the oocyte and sperm genomes, governs genomic...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi-2016-0056
更新日期:2016-10-01 00:00:00
abstract:AIM:The aim was to investigate the effect of miR-377 on DNMT1 expression and cancer phenotype in pancreatic cancer cells. MATERIALS & METHODS:Real-time PCR, luciferase assay, MTT and Annexin-PI staining were used. RESULTS:Decreased miR-377 and increased DNMT1 (verified as a target for mir-377) levels in pancreatic ca...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2016-0175
更新日期:2017-08-01 00:00:00
abstract::DNA modifications represent an integral part of the epigenome and they have a pivotal role in regulation of genome function. Despite the wide variety of analytical techniques that have been developed to detect DNA modifications, their investigation at the single-genome level is only beginning to emerge. In contrast to...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.12.30
更新日期:2012-08-01 00:00:00