Abstract:
AIM:To assess the correlation between KDM6B and estrogen receptor β (ERβ) expression in malignant pleural mesothelioma (MPM). MATERIALS & METHODS:We evaluated gene expression by in silico analysis of microarray data, real-time PCR and western blot in MPM tumors and cell lines. RESULTS & CONCLUSION:We report a strong positive correlation between the expression of KDM6B and ERβ in MPM tumors and cell lines. We describe that, in hypoxia, the HIF2α-KDM6B axis induces an epithelioid morphology and ERβ expression in biphasic MPM cells with estrogen receptor-negative phenotype. Reduced histone H3K27 tri-methylation confirms KDM6B activity under hypoxic conditions. Importantly, cells treated during reoxygenation with the selective ERβ agonist, KB9520, maintain ERβ expression and the less aggressive phenotype acquired in hypoxia.
journal_name
Epigenomicsjournal_title
Epigenomicsauthors
Manente AG,Pinton G,Zonca S,Tavian D,Habib T,Jithesh PV,Fennell D,Nilsson S,Moro Ldoi
10.2217/epi-2016-0025subject
Has Abstractpub_date
2016-09-01 00:00:00pages
1227-38issue
9eissn
1750-1911issn
1750-192Xjournal_volume
8pub_type
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