Combinatorial epigenetic mechanisms and efficacy of early breast cancer inhibition by nutritive botanicals.

abstract：:Imprinted genes are an epigenetically regulated class of genes that are preferentially expressed from one parental allele. A number of these genes are crucial for placental function and embryonic growth in mice and humans. Disruption of imprinted genes is also associated with several neurodevelopmental disorders, alth...

journal_title：Epigenomics

authors： Kernohan KD,Bérubé NG

更新日期：2010-12-01 00:00:00

abstract：AIMS:To investigate if DNA methylation pattern assay could be a new approach to identifying the primary tumor cell origin of the recurrent hepatocellular carcinoma (HCC). MATERIALS & METHODS:Methylation of 24 genes and expression of 22 cancer stem cell (CSC) biomarkers were quantitatively measured in 10 paired primary...

journal_title：Epigenomics

authors： Zhang X,Liu S,Shen C,Wu Y,Zhang L,Chen X,Lu F

更新日期：2015-01-01 00:00:00

abstract：:Aim: This study aimed to identify novel miRNAs (miRs) as regulators of UGT1A gene expression and to evaluate them as potential risk factors for the development of liver fibrosis/cirrhosis. Materials & methods: miRNA target sites in UDP-glucuronosyltransferase 1A (UGT1A) 3'-UTR were predicted and confirmed by luciferas...

journal_title：Epigenomics

authors： Paulusch S,Kalthoff S,Landerer S,Jansen C,Schierwagen R,Klein S,Trebicka J,Strassburg CP

更新日期：2021-01-12 00:00:00

abstract：:Aim: To determine changes in global DNA methylation in monocytes from neonates of women with obesity, as markers of an immune programming resulting from maternal obesity. Materials & methods: Cord blood monocytes were obtained from neonates born to women with obesity and normal weight, genome-wide differentially methy...

journal_title：Epigenomics

authors： Vega-Tapia F,Artigas R,Hernández C,Uauy R,Casanello P,Krause BJ,Castro-Rodriguez JA

更新日期：2020-11-01 00:00:00

abstract：:Aim: The hygiene hypothesis states that a lack of infection in early-life suppresses immune system development, and is linked to respiratory allergy (RA) and childhood acute lymphoblastic leukemia (ALL) risk. Little is known about underlying mechanisms, but DNA methylation is altered in RA and ALL, and in response to ...

journal_title：Epigenomics

authors： Langie SA,Timms JA,De Boever P,McKay JA

更新日期：2019-10-01 00:00:00

abstract：:The widely accepted association between aberrant methylation at specific imprinted loci and distinct imprinting disorders has recently been brought into question by the identification of methylation defects at multiple loci (multilocus methylation defect [MLMD]). Strikingly, in different imprinting disorders, the same...

journal_title：Epigenomics

authors： Eggermann T,Leisten I,Binder G,Begemann M,Spengler S

更新日期：2011-10-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a complex lung disease of unknown etiology. Development of IPF is influenced by both genetic and environmental factors. Gene-expression profiling studies have taught us quite a bit about the biology of this fatal disease, but epigenetic marks may be the missing link that connects...

journal_title：Epigenomics

authors： Yang IV

更新日期：2012-04-01 00:00:00

abstract：AIM:Disclosing the mechanisms that regulate reprogramming memory. MATERIALS & METHODS:We established computational procedure to find DNA methylation somatic memory sites (SMSs) at single CpGs and integrated them with genomics, epigenomics, transcriptomics and imprinting information. RESULTS & CONCLUSION:Reprogramming...

journal_title：Epigenomics

authors： Luu PL,Gerovska D,Schöler HR,Araúzo-Bravo MJ

更新日期：2018-02-01 00:00:00

abstract：:Fundamental aspects of mammalian brain evolution occurred in the context of viviparity and placentation brought about by the epigenetic regulation of imprinted genes. Since the fetal placenta hormonally primes the maternal brain, two genomes in one individual are transgenerationally co-adapted to ensure maternal care ...

journal_title：Epigenomics

authors： Keverne EB

更新日期：2011-04-01 00:00:00

abstract：AIM:The isoflavones genistein, daidzein and equol (daidzein metabolite) have been reported to interact with epigenetic modifications, specifically hypermethylation of tumor suppressor genes. The objective of this study was to analyze and understand the mechanisms by which phytoestrogens act on chromatin in breast cance...

journal_title：Epigenomics

authors： Dagdemir A,Durif J,Ngollo M,Bignon YJ,Bernard-Gallon D

更新日期：2013-02-01 00:00:00

abstract：AIM:To identify regions of aberrant DNA methylation in acute lymphoblastic leukemia (ALL) cells of different subtypes on a genome-wide scale. MATERIALS & METHODS:Whole-genome bisulfite sequencing (WGBS) was used to determine the DNA methylation levels in cells from four pediatric ALL patients of different subtypes. Th...

journal_title：Epigenomics

authors： Wahlberg P,Lundmark A,Nordlund J,Busche S,Raine A,Tandre K,Rönnblom L,Sinnett D,Forestier E,Pastinen T,Lönnerholm G,Syvänen AC

更新日期：2016-10-01 00:00:00

abstract：:Aim: To dynamically analyze the differential m6A methylation during the progression and reversal of hepatic fibrosis. Materials & methods: We induced hepatic fibrosis in C57/BL6 mice by intraperitoneal injection of CCl4. The reversal model of hepatic fibrosis was established by stopping drug after continuous injection...

journal_title：Epigenomics

authors： Cui Z,Huang N,Liu L,Li X,Li G,Chen Y,Wu Q,Zhang J,Long S,Wang M,Sun F,Shi Y,Pan Q

更新日期：2020-10-01 00:00:00

abstract：AIM:To assess the associations between gestational diabetes mellitus (GDM) and DNA methylation levels at genes related to energy metabolism. PATIENTS & METHODS:Ten loci were selected from our recent epigenome-wide association study on GDM. DNA methylation levels were quantified by bisulfite pyrosequencing in 80 placen...

journal_title：Epigenomics

authors： Houde AA,Ruchat SM,Allard C,Baillargeon JP,St-Pierre J,Perron P,Gaudet D,Brisson D,Hivert MF,Bouchard L

更新日期：2015-10-01 00:00:00

abstract：:Arsenic is a nonmutagenic human carcinogen that induces tumors through unknown mechanisms. A growing body of evidence suggests that its carcinogenicity results from epigenetic changes, particularly in DNA methylation. Changes in gene methylation status, mediated by arsenic, have been proposed to activate oncogene expr...

journal_title：Epigenomics

authors： Reichard JF,Puga A

更新日期：2010-02-01 00:00:00

abstract：:The Medical Research Council Clinical Sciences Centre Symposium on Epigenetic Regulation: From Mechanism to Intervention in London, UK, which was held on 20-22 June 2012, attracted 305 participants from around the globe and included 37 speakers and 85 selected poster presentations. The organizing committee, led by Nia...

journal_title：Epigenomics

authors： Chatterjee A

更新日期：2012-10-01 00:00:00

abstract：:Aim: To develop a method for estimating cell-specific effects in epigenomic association studies in the presence of cell type heterogeneity. Materials & methods: We utilized Monte Carlo Expectation-Maximization (MCEM) algorithm with Metropolis-Hastings sampler to reconstruct the 'missing' cell-specific methylations and...

journal_title：Epigenomics

authors： Feng YA,Guo Y,Pain L,Lathrop GM,Laprise C,Moffatt MF,Cookson WO,Liang L

更新日期：2020-12-22 00:00:00

abstract：:Aim: To assess isorhamnetin efficacy for diabetic kidney disease in a Type 2 diabetes mellitus rat model, through investigating its effect at the epigenetic, mRNA and protein levels. Materials & methods: Type 2 diabetes mellitus was induced in rats by streptozotocin and high-fat diet. Rats were treated with isorhamnet...

journal_title：Epigenomics

authors： Matboli M,Ibrahim D,Hasanin AH,Hassan MK,Habib EK,Bekhet MM,Afifi AM,Eissa S

更新日期：2021-01-07 00:00:00

abstract：:Until recently, drug development in oncology was focused on treating most patients for a specific cancer type without taking in account the heterogeneity between these patients in term of response to treatment. Therefore, this type of broad treatment approach excludes the treatment of patient not responding to disease...

journal_title：Epigenomics

authors： Cartron PF,Cheray M,Bretaudeau L

更新日期：2020-01-01 00:00:00

abstract：AIM:Imprinted genes exhibit expression in a parent-of-origin-dependent manner and are critical for child development. Recent limited evidence suggests that prenatal exposure to phthalates, ubiquitous endocrine disruptors, can affect their epigenetic dysregulation. MATERIALS & METHODS:We quantified DNA methylation of n...

journal_title：Epigenomics

authors： Tindula G,Murphy SK,Grenier C,Huang Z,Huen K,Escudero-Fung M,Bradman A,Eskenazi B,Hoyo C,Holland N

更新日期：2018-07-01 00:00:00

abstract：:Histone deacetylase (HDAC)6 is a member of the class IIb HDAC family. This enzyme is zinc-dependent and mainly localized in the cytoplasm. HDAC6 is a unique isoenzyme with two functional catalytic domains and specific physiological roles. Indeed, HDAC6 deacetylates various substrates including α-tubulin and HSP90α, an...

journal_title：Epigenomics

authors： Seidel C,Schnekenburger M,Dicato M,Diederich M

更新日期：2015-01-01 00:00:00

abstract：:Neuromuscular disorders are a heterogeneous group of conditions affecting the neuromuscular system. The aim of this article is to review the major epigenetic findings in motor neuron diseases and major hereditary muscular dystrophies. DNA methylation changes are observed in both hereditary and sporadic forms, and comb...

journal_title：Epigenomics

authors： Coppedè F

更新日期：2020-12-01 00:00:00

abstract：AIM:To identify DNA methylation biomarkers in peripheral blood samples from triple-negative breast cancer (TNBC) patients. MATERIALS & METHODS:We conducted an epigenome-wide association study (EWAS): the most promising markers were identified in 233 TNBC case-control pairs (discovery set) and subsequently validated in...

journal_title：Epigenomics

authors： Bermejo JL,Huang G,Manoochehri M,Mesa KG,Schick M,Silos RG,Ko YD,Brüning T,Brauch H,Lo WY,Hoheisel JD,Hamann U

更新日期：2019-01-01 00:00:00

abstract：:Prostate cancer is the most common cancer in men and the second leading cause of cancer deaths in men in France. Apart from the genetic alterations in prostate cancer, epigenetics modifications are involved in the development and progression of this disease. Epigenetic events are the main cause in gene regulation and ...

journal_title：Epigenomics

authors： Ngollo M,Dagdemir A,Karsli-Ceppioglu S,Judes G,Pajon A,Penault-Llorca F,Boiteux JP,Bignon YJ,Guy L,Bernard-Gallon DJ

更新日期：2014-01-01 00:00:00

abstract：:Aim: We examined methylation changes in cell-free DNA (cfDNA) in metastatic castration-resistant prostate cancer (mCRPC) during treatment. Patients & methods: Genome-wide methylation analysis of sequentially collected cfDNA samples derived from mCRPC patients undergoing androgen-targeting therapy was performed. Result...

journal_title：Epigenomics

authors： Peter MR,Bilenky M,Isserlin R,Bader GD,Shen SY,De Carvalho DD,Hansen AR,Hu P,Fleshner NE,Joshua AM,Hirst M,Bapat B

更新日期：2020-08-01 00:00:00

abstract：:Stephen B Baylin is a codirector of the Cancer Biology Program at The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and the Virginia and DK Ludwig Professor of Oncology and Medicine. Baylin attended Duke University, where he earned his medical degree and completed his internship and first year residency i...

journal_title：Epigenomics

authors： Baylin SB

更新日期：2015-01-01 00:00:00

abstract：:Aim: This study aims to examine the DNA methylation (DNAm) and expression patterns of genes associated with placental angiogenesis in preeclampsia. Materials & methods: DNAm and expression were examined in normotensive (n = 100) and preeclampsia (n = 100) women using pyrosequencing and quantitative real-time PCR respe...

journal_title：Epigenomics

authors： M Dave K,Kaur L,Randhir KN,Mehendale SS,Sundrani DP,Chandak GR,Joshi SR

更新日期：2021-01-20 00:00:00

abstract：:Aim: The contribution of miRNAs as epigenetic regulators of sexually dimorphic gene expression in the placenta is unknown. Materials & methods: 382 placentas from the extremely low gestational age newborns (ELGAN) cohort were evaluated for expression levels of 37,268 mRNAs and 2,102 miRNAs using genome-wide RNA-sequen...

journal_title：Epigenomics

authors： Eaves LA,Phookphan P,Rager JE,Bangma J,Santos HP Jr,Smeester L,O'Shea TM,Fry RC

更新日期：2020-09-01 00:00:00

abstract：:Histone modifications regulate the structural status of chromatin and thereby influence the transcriptional status of genes. These processes are controlled by the recruitment of different enzymes to a specific genomic site. Furthermore, obtaining an understanding of these mechanisms could help delineate alternative tr...

journal_title：Epigenomics

authors： Calcagno DQ,Wisnieski F,Mota ERDS,Maia de Sousa SB,Costa da Silva JM,Leal MF,Gigek CO,Santos LC,Rasmussen LT,Assumpção PP,Burbano RR,Smith MA

更新日期：2019-02-01 00:00:00

abstract：:This study aimed to unveil the functional roles of LINC00221 in hepatocellular carcinoma (HCC). A discovery cohort and a validation cohort were respectively used to identify and verify the clinical value of LINC00221 in HCC. Bioinformatics analysis was performed to explore its potential mechanisms. LINC00221 was upreg...

journal_title：Epigenomics

authors： Feng Y,Dramani Maman ST,Zhu X,Liu X,Bongolo CC,Liang C,Tu J

更新日期：2021-01-07 00:00:00

abstract：:Aim: Epilepsy is a common neurological disorder characterized by recurrent seizures. We performed epigenetic analyses between and within 15 monozygotic (MZ) twin pairs discordant for focal or generalized epilepsy. Methods: DNA methylation analysis was performed using Illumina Infinium MethylationEPIC arrays, in blood ...

journal_title：Epigenomics

authors： Mohandas N,Loke YJ,Hopkins S,Mackenzie L,Bennett C,Berkovic SF,Vadlamudi L,Craig JM

更新日期：2019-06-01 00:00:00