Abstract:
:Hematopoiesis is a regulated multistep process, whereby transcriptional and epigenetic events contribute to progenitor fate determination. miRNAs have emerged as key players in hematopoietic cell development, differentiation and malignant transformation. From embryonic development through to adult life, miRNAs cooperate with, or are regulated, by epigenetic factors. Moreover, recent findings suggest that they contribute to chromatin structural modification, and the functional relevance of this 'epigenetic-miRNA axis' will be discussed in this article. Finally, emerging evidence has highlighted that miRNAs have functional control in human hematopoietic cells, involving targeted recruitment of epigenetic complexes to evolutionarily conserved complementary genomic loci. We propose the existence of epigenetic-miRNA loops that are able to organize the whole gene expression profile in hematopoietic cells.
journal_name
Epigenomicsjournal_title
Epigenomicsauthors
Pagano F,De Marinis E,Grignani F,Nervi Cdoi
10.2217/epi.13.55subject
Has Abstractpub_date
2013-01-01 00:00:00pages
539-52issue
5eissn
1750-1911issn
1750-192Xjournal_volume
5pub_type
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