Maternal obesity is associated with a sex-specific epigenetic programming in human neonatal monocytes.

Abstract:

:Aim: To determine changes in global DNA methylation in monocytes from neonates of women with obesity, as markers of an immune programming resulting from maternal obesity. Materials & methods: Cord blood monocytes were obtained from neonates born to women with obesity and normal weight, genome-wide differentially methylated CpGs were determined using an Infinium MethylationEPIC-BeadChip (850K). Results: No clustering of samples according to maternal BMI was observed, but sex-specific analysis revealed 71,728 differentially methylated CpGs in female neonates from women with obesity (p < 0.01). DAVID analysis showed increased methylation levels within genes involved in the innate immune response and inflammation. Conclusion: Maternal obesity induces, in a sex-specific manner, an epigenetic programming of monocytes that could contribute to disease later in life. Clinical trial registry: This study is registered in ClinicalTrials.gov NCT02903134.

journal_name

Epigenomics

journal_title

Epigenomics

authors

Vega-Tapia F,Artigas R,Hernández C,Uauy R,Casanello P,Krause BJ,Castro-Rodriguez JA

doi

10.2217/epi-2020-0098

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

1999-2018

issue

22

eissn

1750-1911

issn

1750-192X

journal_volume

12

pub_type

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