Abstract:
:Prader-Willi syndrome (PWS) is a relatively rare disorder that originates from paternally inherited deletions and maternal disomy (mUPD) within the 15q11-q13 region or alterations in the PWS imprinting center. Evidence is accumulating that mUPD underlies high prevalence of psychosis among PWS patients. Several genes involved in differentiation and survival of neurons as well as neurotransmission known to act in the development of PWS have been also implicated in schizophrenia. In this article, we provide an overview of genetic and epigenetic underpinnings of psychosis in PWS indicating overlapping points in the molecular background of PWS and schizophrenia. Simultaneously, we highlight the need for studies investigating genetic and epigenetic makeup of the 15q11-q13 in schizophrenia indicating promising candidate genes.
journal_name
Epigenomicsjournal_title
Epigenomicsauthors
Krefft M,Frydecka D,Adamowski T,Misiak Bdoi
10.2217/epi.14.52subject
Has Abstractpub_date
2014-01-01 00:00:00pages
677-88issue
6eissn
1750-1911issn
1750-192Xjournal_volume
6pub_type
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