Abstract:
AIM:To identify DNA methylation biomarkers in peripheral blood samples from triple-negative breast cancer (TNBC) patients. MATERIALS & METHODS:We conducted an epigenome-wide association study (EWAS): the most promising markers were identified in 233 TNBC case-control pairs (discovery set) and subsequently validated in an independent validation set (57 TNBC patients and 124 controls). RESULTS:cg06588802 (LINC00299/ID2) showed a higher methylation in TNBC patients compared with controls (discovery set: 3% increase, p-value = 0.0009; validation set: 2% increase, p-value = 0.01). Consistent results at four neighboring methylation probes and the strong negative correlation (rho = -0.93) with LINC00299 expression add plausibility to this result. CONCLUSION:Hypermethylation of LINC00299 in peripheral blood may constitute a useful circulating biomarker for TNBC.
journal_name
Epigenomicsjournal_title
Epigenomicsauthors
Bermejo JL,Huang G,Manoochehri M,Mesa KG,Schick M,Silos RG,Ko YD,Brüning T,Brauch H,Lo WY,Hoheisel JD,Hamann Udoi
10.2217/epi-2018-0121subject
Has Abstractpub_date
2019-01-01 00:00:00pages
81-93issue
1eissn
1750-1911issn
1750-192Xjournal_volume
11pub_type
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