Abstract:
:Until recently, drug development in oncology was focused on treating most patients for a specific cancer type without taking in account the heterogeneity between these patients in term of response to treatment. Therefore, this type of broad treatment approach excludes the treatment of patient not responding to disease-specific common drugs. In this review, we focus on the different types of epigenetic drugs currently used as DNA methylation inhibitor agents and their limits in patient care due to their lack of specificity. We also highlight the emergence of a new type of epidrug with higher target specificity due to their original mechanism of action: the disruption of protein complexes involved in the epigenetic modifications.
journal_name
Epigenomicsjournal_title
Epigenomicsauthors
Cartron PF,Cheray M,Bretaudeau Ldoi
10.2217/epi-2019-0169subject
Has Abstractpub_date
2020-01-01 00:00:00pages
171-177issue
2eissn
1750-1911issn
1750-192Xjournal_volume
12pub_type
杂志文章相关文献
Epigenomics文献大全abstract:AIM:The isoflavones genistein, daidzein and equol (daidzein metabolite) have been reported to interact with epigenetic modifications, specifically hypermethylation of tumor suppressor genes. The objective of this study was to analyze and understand the mechanisms by which phytoestrogens act on chromatin in breast cance...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi.12.74
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:To study DNA methylation patterns of cortical pyramidal layers susceptible to late-onset Alzheimer's disease (LOAD) neurodegeneration. METHODS:Laser-assisted microdissection to select pyramidal layers' cells in frontal cortex of 32 human brains (18 LOAD) and Infinium DNA Methylation 450K analysis were perfor...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2017-0160
更新日期:2018-11-01 00:00:00
abstract::For the first time, the development of next-generation sequencing technologies has brought about tools to investigate epigenetic alterations in an unbiased, yet genome-wide approach. The importance of this innovative technology is undeniable since it has already been established that changes in DNA methylation play an...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.09.50
更新日期:2010-04-01 00:00:00
abstract::Cancer numbers increasing, cases heterogeneity and the drug resistance emergence have pushed scientists to search for innovative solutions for patients and epimutations can be one. Methylated DNA, modified nucleosomes and noncoding RNAs are found in all cells, including tumor cells. They are intracellular actors but a...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2019-0170
更新日期:2020-01-01 00:00:00
abstract::Children exposed to early-life adversity carry a greater risk of poor health and disease into adulthood. This increased disease risk is shadowed by changes in the epigenome. Epigenetics can change gene expression to modify disease risk; unfortunately, how epigenetics are changed by the environment is unclear. It is kn...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.15.74
更新日期:2015-10-01 00:00:00
abstract::Asthma is a chronic disease which causes recurrent breathlessness affecting 300 million people worldwide of whom 250,000 die annually. The epigenome is a set of heritable modifications and tags that affect the genome without changing the intrinsic DNA sequence. These marks include DNA methylation, modifications to his...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.15.53
更新日期:2015-01-01 00:00:00
abstract::Antisense RNA is the first noncoding RNA found to have a regulatory function. With the advances of biological science, it has been recognized that the function of antisense RNAs is not only limited to post-transcriptional regulation, but extends to transcriptional regulation of various important genes leading to epige...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.09.46
更新日期:2010-02-01 00:00:00
abstract::Aim: We aimed to explore the roles of noncoding RNAs (ncRNAs) in renal cell carcinoma. Materials & methods: The altered expressions of miR-196a2, miR-499a, H19, MALAT1 and GAS5, as well as some target transcripts were identified by quantitative real-time reverse transcription polymerase chain reaction. Results: Up-reg...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2019-0120
更新日期:2020-02-01 00:00:00
abstract::This article focuses on the epigenetic alterations of aberrant promoter hypermethylation of genes, and histone modifications or RNA interference in cancer cells. Current knowledge of the hypermethylation of allele(s) in classical tumor suppressor genes in inherited and sporadic cancer, candidate tumor suppressor and o...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.10.64
更新日期:2011-02-01 00:00:00
abstract:AIM:Aberrant epigenetic events are important contributors to the pathogenesis of different types of cancers and dietary botanicals with epigenetic properties can influence early cancer development leading to cancer prevention effects. We sought to investigate potential combinatorial effects of bioactive dietary compone...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2016-0024
更新日期:2016-08-01 00:00:00
abstract::Aim: Myotonic dystrophy type 1 (DM1) is caused by an unstable trinucleotide (CTG) expansion at the DMPK gene locus. Cognitive dysfunctions are often observed in the condition. We investigated the association between DMPK blood DNA methylation (DNAm) and cognitive functions in DM1, considering expansion length and vari...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2020-0328
更新日期:2020-12-01 00:00:00
abstract::Melanoma is a leading cause of death from cancers in the USA. While exposure to UV radiation has long been identified as a primary risk factor for melanoma, molecular mechanisms directly linking UV radiation to the development of melanoma, especially metastatic melanoma, are poorly understood. Besides abnormality in s...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.11.114
更新日期:2012-02-01 00:00:00
abstract::Aim: The goal of this study was to comprehensively interrogate and map DNA methylation across 16 CpG-dense regions previously associated with oral and pharyngeal squamous cell carcinoma (OPSCC). Materials & methods: Targeted multiplex bisulfite amplicon sequencing was performed on four OPSCC cell lines and primary non...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2018-0172
更新日期:2019-07-01 00:00:00
abstract:AIM:We performed a study to identify the role of microRNA in thymoma. PATIENTS & METHODS:One hundred twenty-three thymoma patients with clinical information and miRNA expression data from The Cancer Genome Atlas were included in the study. Comprehensive bioinformatics analysis was integrated in our analysis. RESULTS ...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2016-0161
更新日期:2017-05-01 00:00:00
abstract::Aim: To dynamically analyze the differential m6A methylation during the progression and reversal of hepatic fibrosis. Materials & methods: We induced hepatic fibrosis in C57/BL6 mice by intraperitoneal injection of CCl4. The reversal model of hepatic fibrosis was established by stopping drug after continuous injection...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2019-0365
更新日期:2020-10-01 00:00:00
abstract:AIMS:Epigenetic signatures of germline cells are dynamically reprogrammed to induce appropriate differentiation, development and sex specification. We investigated sex-specific epigenetic changes in mouse fetal germ cells (FGCs) and neonatal germ cells. MATERIALS & METHODS:Six histone marks in mouse E13.5 FGCs and P1 ...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2018-0193
更新日期:2019-04-01 00:00:00
abstract::The widely accepted association between aberrant methylation at specific imprinted loci and distinct imprinting disorders has recently been brought into question by the identification of methylation defects at multiple loci (multilocus methylation defect [MLMD]). Strikingly, in different imprinting disorders, the same...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.11.84
更新日期:2011-10-01 00:00:00
abstract::Aim: To identify pregnancy-associated changes in cervical noncoding RNA (ncRNA), including miRNA and long noncoding RNA (lncRNA), and their potential effects on biologic processes. Materials & methods: We enrolled 21 pregnant women with term deliveries (≥37 weeks' gestation) in a prospective cohort and collected cervi...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2019-0231
更新日期:2020-06-01 00:00:00
abstract:AIM:To identify regions of aberrant DNA methylation in acute lymphoblastic leukemia (ALL) cells of different subtypes on a genome-wide scale. MATERIALS & METHODS:Whole-genome bisulfite sequencing (WGBS) was used to determine the DNA methylation levels in cells from four pediatric ALL patients of different subtypes. Th...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2016-0052
更新日期:2016-10-01 00:00:00
abstract::Stephen B Baylin is a codirector of the Cancer Biology Program at The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and the Virginia and DK Ludwig Professor of Oncology and Medicine. Baylin attended Duke University, where he earned his medical degree and completed his internship and first year residency i...
journal_title:Epigenomics
pub_type: 面试
doi:10.2217/epi.15.61
更新日期:2015-01-01 00:00:00
abstract::Sepsis is a life-threatening condition that occurs when the body responds to an infection damaging its own tissues. Sepsis survivors sometimes suffer from immunosuppression increasing the risk of death. To our best knowledge, there is no 'gold standard' for defining immunosuppression except for a composite clinical en...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2019-0329
更新日期:2020-04-01 00:00:00
abstract::Histone deacetylase (HDAC)6 is a member of the class IIb HDAC family. This enzyme is zinc-dependent and mainly localized in the cytoplasm. HDAC6 is a unique isoenzyme with two functional catalytic domains and specific physiological roles. Indeed, HDAC6 deacetylates various substrates including α-tubulin and HSP90α, an...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.14.69
更新日期:2015-01-01 00:00:00
abstract::Aim: This study aims to examine the DNA methylation (DNAm) and expression patterns of genes associated with placental angiogenesis in preeclampsia. Materials & methods: DNAm and expression were examined in normotensive (n = 100) and preeclampsia (n = 100) women using pyrosequencing and quantitative real-time PCR respe...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2020-0318
更新日期:2021-01-20 00:00:00
abstract::Aim: To determine changes in global DNA methylation in monocytes from neonates of women with obesity, as markers of an immune programming resulting from maternal obesity. Materials & methods: Cord blood monocytes were obtained from neonates born to women with obesity and normal weight, genome-wide differentially methy...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2020-0098
更新日期:2020-11-01 00:00:00
abstract::Aim: The role of circRNAs in esophageal squamous cell cancer (ESCC) remains unclear. Materials & methods: Here we profiled six pair plasma circRNA in ESCC based on RNA sequencing, and then verified the elevation of hsa_circ_0004771 in 20 cancer tissues and 105 pair case-control plasma samples by quantitative reverse t...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2019-0404
更新日期:2020-04-01 00:00:00
abstract::Arsenic is a nonmutagenic human carcinogen that induces tumors through unknown mechanisms. A growing body of evidence suggests that its carcinogenicity results from epigenetic changes, particularly in DNA methylation. Changes in gene methylation status, mediated by arsenic, have been proposed to activate oncogene expr...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.09.45
更新日期:2010-02-01 00:00:00
abstract:AIM:To show that an increased correlation between CpGs after selection through an epigenome-wide association studies (EWAS) might translate into biased replication results. METHODS:Pairwise correlation coefficients between CpGs selected in two published EWAS, the top hits replication, Bonferroni p-values, Benjamini-Ho...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2017-0073
更新日期:2017-12-01 00:00:00
abstract:AIM:In order to identify regulators of foam cells, we studied the H3K27 demethylase Kdm6b (also known as Jmjd3), a known regulator of macrophages, in controlling the transcriptional profile of foam cells. MATERIALS & METHODS:Foam cells from Kdm6b-deleted or Kdm6b wild-type mice were isolated and used for RNA-sequencin...
journal_title:Epigenomics
pub_type: 杂志文章
doi:10.2217/epi-2016-0152
更新日期:2017-04-01 00:00:00
abstract::Fundamental aspects of mammalian brain evolution occurred in the context of viviparity and placentation brought about by the epigenetic regulation of imprinted genes. Since the fetal placenta hormonally primes the maternal brain, two genomes in one individual are transgenerationally co-adapted to ensure maternal care ...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.11.10
更新日期:2011-04-01 00:00:00
abstract::Idiopathic pulmonary fibrosis (IPF) is a complex lung disease of unknown etiology. Development of IPF is influenced by both genetic and environmental factors. Gene-expression profiling studies have taught us quite a bit about the biology of this fatal disease, but epigenetic marks may be the missing link that connects...
journal_title:Epigenomics
pub_type: 杂志文章,评审
doi:10.2217/epi.12.10
更新日期:2012-04-01 00:00:00