Abstract:
AIM:We examined maternal prepregnancy anthropometry and cord blood DNA methylation. METHODS:Associations between maternal measures (i.e., weight, height, waist circumference, hip circumference, skinfolds, leptin) and methylation β-values at each CpG (measured by the Infinium MethylationEPIC BeadChip) were estimated among 391 singletons. RESULTS:Total of 18% of mothers were obese (body mass index ≥ 30) and 27% centrally obese (waist-to-hip ratio ≥ 0.85). One Bonferroni significant CpG with respect to obesity (cg02975187) and two with central obesity (cg12053563, cg12549355) were identified (p < 6 × 10-8). A suggestive association (p < 10-6) was observed at SFRS8 with increasing body mass index. SFRS8 was previously identified with propensity for weight gain in adults. CONCLUSION:While associations identified with multiple measures related to maternal adiposity suggest different pathways, methylation differences were small in magnitude.
journal_name
Epigenomicsjournal_title
Epigenomicsauthors
Yeung EH,Guan W,Mumford SL,Silver RM,Zhang C,Tsai MY,Schisterman EFdoi
10.2217/epi-2018-0099subject
Has Abstractpub_date
2019-02-01 00:00:00pages
187-198issue
2eissn
1750-1911issn
1750-192Xjournal_volume
11pub_type
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