Abstract:
AIM:To identify differentially methylated probes (DMPs) and regions (DMRs) in relation to chronic obstructive pulmonary disease (COPD) and lung function traits. METHODS:We performed an epigenome-wide association study of COPD and spirometric parameters, including forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC, in blood DNA using the Infinium HumanMethylation450 (n = 100, a Korean COPD cohort). RESULTS:We found one significant DMP (cg03559389, DIP2C) and 104 significant DMRs after multiple-testing correction. Of these, 34 DMRs mapped to genes differential expressed with respect to the same trait. Five of the genes were associated with more than two traits: CTU2, USP36, ZNF516, KLK10 and CPT1B. CONCLUSION:We identified novel differential methylation loci related to COPD and lung function in blood DNA in Koreans and confirmed previous findings in non-Asians. Epigenetic modification could contribute to the etiology of these phenotypes.
journal_name
Epigenomicsjournal_title
Epigenomicsauthors
Lee MK,Hong Y,Kim SY,Kim WJ,London SJdoi
10.2217/epi-2017-0002subject
Has Abstractpub_date
2017-07-01 00:00:00pages
971-984issue
7eissn
1750-1911issn
1750-192Xjournal_volume
9pub_type
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