Abstract:
:Aim: To uncover a novel lncRNA-miRNA-mRNA network associated with high-grade serous ovarian cancer metastasis. Material & methods: The candidate differentially expressed lncRNAs were obtained from RNA-sequencing data and determined by functional experiments. The downstream miRNAs and mRNAs were identified by bioinformatic prediction and subjected to functional enrichment analysis. Results: The expression levels of lncRNA ENTPD1-AS1/PRANCR/NR2F2-AS1 were reduced in omental metastatic tissues. Similar differential expression patterns of these lncRNAs were also found in lnCAR database and we verified their tumor suppressive roles by performing functional experiments. Furthermore, we predicted miRNAs and mRNAs via bioinformatic tools and validated their alteration in expression levels in presence of lncRNA interference. Conclusion: We proposed a potential ceRNA regulatory mechanism in high-grade serous ovarian cancer omental metastasis.
journal_name
Epigenomicsjournal_title
Epigenomicsauthors
Li X,Yu S,Yang R,Wang Q,Liu X,Ma M,Li Y,Wu Sdoi
10.2217/epi-2020-0097subject
Has Abstractpub_date
2020-07-01 00:00:00pages
1175-1191issue
14eissn
1750-1911issn
1750-192Xjournal_volume
12pub_type
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