The epigenome in pluripotency and differentiation.

abstract：:There are numerous examples of enduring effects of early experience on gene transcription and neural function. We review the emerging evidence for epigenetics as a candidate mechanism for such effects. There is now evidence that intracellular signals activated by environmental events can directly modify the epigenetic...

journal_title：Epigenomics

authors： Sng J,Meaney MJ

更新日期：2009-10-01 00:00:00

abstract：:The E3 ubiquitin ligase UBE3A, also known as E6-AP, has a multitude of ascribed functions and targets relevant to human health and disease. Epigenetic regulation of the UBE3A gene by parentally imprinted noncoding transcription within human chromosome 15q11.2-q13.3 is responsible for the maternal-specific effects of 1...

journal_title：Epigenomics

authors： LaSalle JM,Reiter LT,Chamberlain SJ

更新日期：2015-10-01 00:00:00

abstract：:Alzheimer's disease (AD) and Parkinson's disease (PD) are two common neurodegenerative diseases that result in the progressive damage or death of neurons. Environmental agents have the potential to damage the developing and mature nervous system, resulting in neurodegenerative diseases. Heritable changes in gene expre...

journal_title：Epigenomics

authors： Kwok JB

更新日期：2010-10-01 00:00:00

abstract：AIM:To develop a reliable method for whole genome analysis of DNA methylation. MATERIALS & METHODS:Genome-scale analysis of DNA methylation includes affinity-based approaches such as enrichment using methyl-CpG-binding proteins. One of these methods, the methylated-CpG island recovery assay (MIRA), is based on the hig...

journal_title：Epigenomics

authors： Jung M,Kadam S,Xiong W,Rauch TA,Jin SG,Pfeifer GP

更新日期：2015-08-01 00:00:00

abstract：:Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is widely used for mapping histone modifications, histone proteins, chromatin regulators, transcription factors and other DNA-binding proteins. It has played a significant role in our understanding of disease mechanisms and in exploring epigenetic changes...

journal_title：Epigenomics

authors： Yan H,Tian S,Slager SL,Sun Z

更新日期：2016-09-01 00:00:00

abstract：:Epigenetic modifications established during gametogenesis regulate transcription and other nuclear processes in gametes, but also have influences in the zygote, embryo and postnatal life. This is best understood for DNA methylation which, established at discrete regions of the oocyte and sperm genomes, governs genomic...

journal_title：Epigenomics

authors： Stewart KR,Veselovska L,Kelsey G

更新日期：2016-10-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a complex lung disease of unknown etiology. Development of IPF is influenced by both genetic and environmental factors. Gene-expression profiling studies have taught us quite a bit about the biology of this fatal disease, but epigenetic marks may be the missing link that connects...

journal_title：Epigenomics

authors： Yang IV

更新日期：2012-04-01 00:00:00

abstract：:Prostate cancer is the most common cancer in men and the second leading cause of cancer deaths in men in France. Apart from the genetic alterations in prostate cancer, epigenetics modifications are involved in the development and progression of this disease. Epigenetic events are the main cause in gene regulation and ...

journal_title：Epigenomics

authors： Ngollo M,Dagdemir A,Karsli-Ceppioglu S,Judes G,Pajon A,Penault-Llorca F,Boiteux JP,Bignon YJ,Guy L,Bernard-Gallon DJ

更新日期：2014-01-01 00:00:00

abstract：:Epigenetic enzymes are emerging as crucial controllers of macrophages, innate immune cells that determine the outcome of many inflammatory diseases. Recent studies demonstrate that the activity of particular chromatin-modifying enzymes is regulated by the availability of specific metabolites like acetyl-coenzyme A, S-...

journal_title：Epigenomics

authors： Baardman J,Licht I,de Winther MP,Van den Bossche J

更新日期：2015-10-01 00:00:00

abstract：AIM:We performed a study to identify the role of microRNA in thymoma. PATIENTS & METHODS:One hundred twenty-three thymoma patients with clinical information and miRNA expression data from The Cancer Genome Atlas were included in the study. Comprehensive bioinformatics analysis was integrated in our analysis. RESULTS ...

journal_title：Epigenomics

authors： Wei J,Liu Z,Wu K,Yang D,He Y,Chen GG,Zhang J,Lin J

更新日期：2017-05-01 00:00:00

abstract：AIM:There is a growing concern about the potential adverse effects of high dose folic acid (FA) supplementation before and during pregnancy. FA metabolism generates S-adenosyl methionine (SAM) which is an important cofactor of epigenetic programming. We sought to assess the impact of a large dose of SAM on early embryo...

journal_title：Epigenomics

authors： Shojaei Saadi HA,Gagné D,Fournier É,Baldoceda Baldeon LM,Sirard MA,Robert C

更新日期：2016-08-01 00:00:00

abstract：:Melanoma is a leading cause of death from cancers in the USA. While exposure to UV radiation has long been identified as a primary risk factor for melanoma, molecular mechanisms directly linking UV radiation to the development of melanoma, especially metastatic melanoma, are poorly understood. Besides abnormality in s...

journal_title：Epigenomics

authors： Perera RJ,Ray A

更新日期：2012-02-01 00:00:00

abstract：AIM:Transcriptomic and methylomic patterns represent two major OMIC data sources impacted by both inheritable genetic information and environmental factors, and have been widely used as disease diagnosis and prognosis biomarkers. MATERIALS & METHODS:Modern transcriptomic and methylomic profiling technologies detect th...

journal_title：Epigenomics

authors： Xu C,Liu J,Yang W,Shu Y,Wei Z,Zheng W,Feng X,Zhou F

更新日期：2018-04-01 00:00:00

abstract：:Aim: The hygiene hypothesis states that a lack of infection in early-life suppresses immune system development, and is linked to respiratory allergy (RA) and childhood acute lymphoblastic leukemia (ALL) risk. Little is known about underlying mechanisms, but DNA methylation is altered in RA and ALL, and in response to ...

journal_title：Epigenomics

authors： Langie SA,Timms JA,De Boever P,McKay JA

更新日期：2019-10-01 00:00:00

abstract：:Aim: To identify lncRNAs targeting GSK3β in MDD. Materials & methods: The levels of GSK3β and its three targeting lncRNAs (gsk3β antisense AS1, AS2 and AS3) were detected in 52 patients with major depressive disorder (MDD) before and after 8 weeks of escitalopram treatment. The functional study was evaluated using the...

journal_title：Epigenomics

authors： Liu Z,Li X,Chen C,Sun N,Wang Y,Yang C,Xu Y,Xu Y,Zhang K

更新日期：2020-10-01 00:00:00

abstract：AIMS:To investigate if DNA methylation pattern assay could be a new approach to identifying the primary tumor cell origin of the recurrent hepatocellular carcinoma (HCC). MATERIALS & METHODS:Methylation of 24 genes and expression of 22 cancer stem cell (CSC) biomarkers were quantitatively measured in 10 paired primary...

journal_title：Epigenomics

authors： Zhang X,Liu S,Shen C,Wu Y,Zhang L,Chen X,Lu F

更新日期：2015-01-01 00:00:00

abstract：AIM:To investigate epigenomic changes in pregnancy and early postpartum in women with and without type 2 diabetes. METHODS:Dimethylation of histones H3K4, H3K9, H3K27, H3K36 and H3K79 was measured in white blood cells of women at 30 weeks pregnancy, at 8-10 and 20 weeks postpartum and in never-pregnant women. RESULTS...

journal_title：Epigenomics

authors： Michalczyk AA,Janus ED,Judge A,Ebeling PR,Best JD,Ackland MJ,Asproloupos D,Dunbar JA,Ackland ML

更新日期：2018-04-01 00:00:00

abstract：:The Medical Research Council Clinical Sciences Centre Symposium on Epigenetic Regulation: From Mechanism to Intervention in London, UK, which was held on 20-22 June 2012, attracted 305 participants from around the globe and included 37 speakers and 85 selected poster presentations. The organizing committee, led by Nia...

journal_title：Epigenomics

authors： Chatterjee A

更新日期：2012-10-01 00:00:00

abstract：:This study aimed to unveil the functional roles of LINC00221 in hepatocellular carcinoma (HCC). A discovery cohort and a validation cohort were respectively used to identify and verify the clinical value of LINC00221 in HCC. Bioinformatics analysis was performed to explore its potential mechanisms. LINC00221 was upreg...

journal_title：Epigenomics

authors： Feng Y,Dramani Maman ST,Zhu X,Liu X,Bongolo CC,Liang C,Tu J

更新日期：2021-01-07 00:00:00

abstract：AIM:Aberrant epigenetic events are important contributors to the pathogenesis of different types of cancers and dietary botanicals with epigenetic properties can influence early cancer development leading to cancer prevention effects. We sought to investigate potential combinatorial effects of bioactive dietary compone...

journal_title：Epigenomics

authors： Li Y,Buckhaults P,Cui X,Tollefsbol TO

更新日期：2016-08-01 00:00:00

abstract：AIM:To assess the correlation between KDM6B and estrogen receptor β (ERβ) expression in malignant pleural mesothelioma (MPM). MATERIALS & METHODS:We evaluated gene expression by in silico analysis of microarray data, real-time PCR and western blot in MPM tumors and cell lines. RESULTS & CONCLUSION:We report a strong ...

journal_title：Epigenomics

authors： Manente AG,Pinton G,Zonca S,Tavian D,Habib T,Jithesh PV,Fennell D,Nilsson S,Moro L

更新日期：2016-09-01 00:00:00

abstract：AIM:The aim was to investigate the effect of miR-377 on DNMT1 expression and cancer phenotype in pancreatic cancer cells. MATERIALS & METHODS:Real-time PCR, luciferase assay, MTT and Annexin-PI staining were used. RESULTS:Decreased miR-377 and increased DNMT1 (verified as a target for mir-377) levels in pancreatic ca...

journal_title：Epigenomics

authors： Azizi M,Fard-Esfahani P,Mahmoodzadeh H,Fazeli MS,Azadmanesh K,Zeinali S,Teimoori-Toolabi L

更新日期：2017-08-01 00:00:00

abstract：:Until recently, drug development in oncology was focused on treating most patients for a specific cancer type without taking in account the heterogeneity between these patients in term of response to treatment. Therefore, this type of broad treatment approach excludes the treatment of patient not responding to disease...

journal_title：Epigenomics

authors： Cartron PF,Cheray M,Bretaudeau L

更新日期：2020-01-01 00:00:00

abstract：:Aberrant epigenomic programming is a hallmark of acute myeloid leukemia. This is partially due to somatic mutations that perturb cytosine methylation, histone post-translational modifications and transcription factors. Remarkably, mutations in the IDH1 and IDH2 genes perturb the epigenome through all three of these me...

journal_title：Epigenomics

authors： Garrett-Bakelman FE,Melnick AM

更新日期：2016-07-01 00:00:00

abstract：AIM:To identify DNA methylation biomarkers in peripheral blood samples from triple-negative breast cancer (TNBC) patients. MATERIALS & METHODS:We conducted an epigenome-wide association study (EWAS): the most promising markers were identified in 233 TNBC case-control pairs (discovery set) and subsequently validated in...

journal_title：Epigenomics

authors： Bermejo JL,Huang G,Manoochehri M,Mesa KG,Schick M,Silos RG,Ko YD,Brüning T,Brauch H,Lo WY,Hoheisel JD,Hamann U

更新日期：2019-01-01 00:00:00

abstract：AIM:To identify differentially methylated probes (DMPs) and regions (DMRs) in relation to chronic obstructive pulmonary disease (COPD) and lung function traits. METHODS:We performed an epigenome-wide association study of COPD and spirometric parameters, including forced expiratory volume in 1 s (FEV1), forced vital ca...

journal_title：Epigenomics

authors： Lee MK,Hong Y,Kim SY,Kim WJ,London SJ

更新日期：2017-07-01 00:00:00

abstract：:Manipulation of chromatin, in which genomic DNA is packaged, is a fundamental requirement for all DNA-based metabolic processes in eukayotic cells. Histone variant incorporation, histone post-translational modifications, and ATP-dependent chromatin remodeling are three major strategies for chromatin manipulation, and ...

journal_title：Epigenomics

authors： Bao Y

更新日期：2011-06-01 00:00:00

abstract：:Histone deacetylase (HDAC)6 is a member of the class IIb HDAC family. This enzyme is zinc-dependent and mainly localized in the cytoplasm. HDAC6 is a unique isoenzyme with two functional catalytic domains and specific physiological roles. Indeed, HDAC6 deacetylates various substrates including α-tubulin and HSP90α, an...

journal_title：Epigenomics

authors： Seidel C,Schnekenburger M,Dicato M,Diederich M

更新日期：2015-01-01 00:00:00

abstract：:Aim: Epilepsy is a common neurological disorder characterized by recurrent seizures. We performed epigenetic analyses between and within 15 monozygotic (MZ) twin pairs discordant for focal or generalized epilepsy. Methods: DNA methylation analysis was performed using Illumina Infinium MethylationEPIC arrays, in blood ...

journal_title：Epigenomics

authors： Mohandas N,Loke YJ,Hopkins S,Mackenzie L,Bennett C,Berkovic SF,Vadlamudi L,Craig JM

更新日期：2019-06-01 00:00:00

abstract：:Aim: We aimed to explore the roles of noncoding RNAs (ncRNAs) in renal cell carcinoma. Materials & methods: The altered expressions of miR-196a2, miR-499a, H19, MALAT1 and GAS5, as well as some target transcripts were identified by quantitative real-time reverse transcription polymerase chain reaction. Results: Up-reg...

journal_title：Epigenomics

authors： Fawzy MS,Toraih EA,Ageeli EA,Al-Qahtanie SA,Hussein MH,Kandil E

更新日期：2020-02-01 00:00:00