Abstract:
OBJECTIVES:Neuropathies often accompany vitamin B12 deficiency. Since many neuropathies are linked to oxidative stress and since B12 has both antioxidant and neurotrophic properties, B12 may also be effective treatment in non-deficient subjects. Thus, the characteristics and predictors of B12-responsive neuropathies and their relationship to disorders associated with increased oxidative stress (oxidant risks) were examined. METHODS:Retrospective review of 78 subjects with neurological abnormalities treated with B12 and evaluated by the measurement of B12 and the B12-dependent metabolites, methylmalonic acid (MMA), and homocysteine. RESULTS:Sixty-five subjects had neurological improvement (83%), including 35 with other known causes of neuropathy. Only two responders had B12-responsive macrocytosis. Pretherapy B12, MMA, and homocysteine values were normal in 72, 33 and 54% of responders, with all three normal in 23%. Moreover, B12 therapy did not significantly decrease elevated MMA and homocysteine levels in 20 and 37%, respectively, of responders tested but did decrease both metabolites in 75% of evaluable non-responders. At least one oxidant risk was present in 41 of the 46 responders with normal B12 levels (89%). Oral therapy was effective, but parenteral B12 improved responses in four subjects. DISCUSSION:B12-responsive neuropathies are thus (1) common even when confounding disorders are present; (2) dissociated from the presence of hematological abnormalities; (3) dissociated from the presence of B12-responsive metabolical abnormalities; and (4) associated with the presence of oxidant risks when B12 levels are normal. Since no predictors of responses to B12 therapy were identified, empiric trials with parenteral B12 should be considered in appropriate subjects.
journal_name
Nutr Neuroscijournal_title
Nutritional neuroscienceauthors
Solomon LRdoi
10.1179/1476830515Y.0000000006subject
Has Abstractpub_date
2016-05-01 00:00:00pages
162-8issue
4eissn
1028-415Xissn
1476-8305journal_volume
19pub_type
杂志文章abstract:OBJECTIVE:Major depressive disorder is a debilitating and recurrent psychiatric disorder. Blueberries have several biological properties, including neuroprotective effects, through antioxidant and anti-inflammatory actions. The aim of this study was to evaluate the effect of blueberry extract on depressive-like behavio...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2020.1819104
更新日期:2020-09-21 00:00:00
abstract::Carnosine (beta-alanyl-L-histidine) and its derivative anserine (beta-alanyl-1-methyl-L-histidine) are antioxidants and putative neurotransmitters in the brain. These dipeptides are rich in the commercially available supplement chicken breast extract (CBEX). To clarify the effects of CBEX on the brain, we examined whe...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/10284150701587338
更新日期:2007-06-01 00:00:00
abstract::Insulin resistance is implicated in the pathophysiological changes associated with Alzheimer's disease, and pharmaceutical treatments that overcome insulin resistance improve memory function in subjects with mild cognitive impairment (MCI) and early Alzheimer's disease. Chromium (Cr) supplementation improves glucose d...
journal_title:Nutritional neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.1179/147683010X12611460764084
更新日期:2010-06-01 00:00:00
abstract:PURPOSE:The aim of this study was investigating the effect of omega-3 fatty acids (ω-3 FAs) on brain-derived neurotrophic factor (BDNF) gene expression, using in vivo and in vitro models, to unravel the potential mechanisms of polyunsaturated fatty acids use in obesity. MATERIALS AND METHODS:Twenty-nine Sprague-Dawley...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2016.1180859
更新日期:2017-10-01 00:00:00
abstract::The effects of noise-induced arousal on chewing, subjective motivation to eat, the pleasantness of sweet food, and food intake were investigated. Twenty-four healthy normal weight male subjects received cookies differing in sucrose content (2%, 11%, 18% or 27%) before, during, and after 10 min of intermittent white no...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.1998.11747231
更新日期:1998-01-01 00:00:00
abstract::In this article, the second of a series on the analysis of time to event data, we address the case in which multiple predictors (covariates) that may influence the time to an event are taken into account. The hazard function is introduced, and is given in a form useful for assessing the impact of multiple covariates o...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415031000079694
更新日期:2003-04-01 00:00:00
abstract::We compared the maturation of the monosynaptic stretch reflex in control rats and in rats submitted to neonatal malnutrition. Electrical stimulations of the sciatic nerve were applied in wakeful rats of different ages (21-90 days) to record, by surface electrodes, the maximal direct motor response (M(max)) or the maxi...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/147683008X344138
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVES:Sodium metabisulfite as a food preservative can affect the central nervous system. Curcumin, the main ingredient of turmeric has neuroprotective activity. This study was designed to evaluate the effects of sulfite and curcumin on the medial prefrontal cortex (mPFC) using stereological methods. METHODS:Thirt...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/1476830514Y.0000000123
更新日期:2015-08-01 00:00:00
abstract::Young children respond to energy dilution achieved using fat or sugar substitutes by compensating for reduced energy within a single meal. The ability to respond to energy dilution in the short term may diminish with age, since adults do not reliably demonstrate accurate caloric compensation in the short term. Two exp...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2000.11747329
更新日期:2000-01-01 00:00:00
abstract::ABSTRACTObjectives: One factor contributing to the development of obesity is overeating palatable food. The palatability of food is driven by specific energy yielding combinations and flavor profiles that may contribute to its overconsumption. In rodents, restricted access to palatable food (PF) is a strong stimulus t...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2019.1651104
更新日期:2019-08-16 00:00:00
abstract::Background: This study aimed to analyse the impact of des-acyl and acyl ghrelin (AG) on a wide range of muscular and metabolic markers and in order to discover the possible relationships and interactions of des-acylated ghrelin (DAG) on eating disorders.Materials & Methods: A total of 88 subjects (64 women and 24 men,...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2020.1752997
更新日期:2020-04-15 00:00:00
abstract:OBJECTIVES:Coenzyme Q10 (CoQ10, ubiquinone) stands among the safest supplements in the elderly to protect against cardiovascular disorders. Noteworthy, CoQ10 deficiency is common in many surviving stroke patients as they are mostly prescribed statins for the secondary prevention of stroke incidence lifelong. Accordingl...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2017.1376928
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVES:Combat deployments are characterized by high operational demands with limited opportunities for sleep leading to fatigue and degraded cognitive and operational performance. Caffeine in moderate doses is recognized as an effective intervention for physical and cognitive decrements associated with sleep loss. ...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2018.1443996
更新日期:2019-11-01 00:00:00
abstract::The treatment of resistant depression has involved the use of various adjuncts in addition to the antidepressant, such as lithium or liothyronine (T3). This case report describes a woman with a history of chronic depression (dysthymic disorder), unresponsive to a number of traditional antidepressants, who was treated ...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.1998.11747241
更新日期:1998-01-01 00:00:00
abstract::Endogenous neuropeptide Y (NPY) levels increase during fasting and before dark onset in rats. The feeding that follows these states elicits the release of serotonin in the lateral hypothalamus (LH), as part of the physiological mechanisms controlling satiety. With the hypothesis that exogenous NPY-induced feeding shou...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/10284150400012794
更新日期:2004-08-01 00:00:00
abstract::The uncertainty of the role of serum cholesterol in neurodevelopment of children has largely hampered the implementation of the fat recommendation to children in the general population. We explored whether serum cholesterol concentrations are associated with cognitive achievements, academic performance in school-aged ...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/147683009X423328
更新日期:2009-08-01 00:00:00
abstract::Pseudotumor cerebri occurs quite rarely in the pediatric population and its clinical features differ from adults in many ways. Intracranial hypertension with papilledema should obviously be treated promptly to avoid permanent visual damage, but various more or less invasive options have been proposed over the years, f...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/147683008X301388
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVES:Hypnotic, analgesic, anticonvulsant, and antioxidant effects of Rosa damascena have been reported. This study, investigated the effect of R. damascena hydroalcoholic extract on memory performance in a scopolamine-induced memory impairment model. METHODS:The rats were divided into control group received just...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/1476830514Y.0000000137
更新日期:2015-10-01 00:00:00
abstract::The effects of iodine deficiency on growth and development are known as the iodine deficiency disorders (IDDs). Most common is goitre at all ages, but most significant are the effects on brain development during pregnancy. The major effect of iodine deficiency is the clinical syndrome of endemic cretinism characterise...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.1999.11747292
更新日期:1999-01-01 00:00:00
abstract::To clarify whether L-ornithine and/or its metabolite involves sedative and hypnotic effects under social separation stress, the effects of intracerebroventricular (i.c.v.) injection of L-ornithine and polyamines (putrescine, spermidine and spermine) were compared in chicks. Birds were injected i.c.v. with 0.5 mumol of...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/147683010X12611460763481
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVES:Choline (Ch) is an essential nutrient that acts as a cognitive facilitator when administered during perinatal periods, and it has been recognised as a 'pharmacological' agent that can ease cognitive dysfunctions provoked by exposure to damaging stimuli during early developmental stages. The aim of the presen...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2015.1126444
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVES:Ethanol consumption induces neurological disorders including cognitive dysfunction. Oxidative damage is considered a likely cause of cognitive deficits. We aimed to investigate the effects of rosmarinic acid (RA) in different doses for 30 days on chronic ethanol-induced cognitive dysfunction using the passiv...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2016.1203125
更新日期:2017-11-01 00:00:00
abstract::A high-fat diet (HFD) during pregnancy influences the neurodevelopment of progeny, particularly in the hippocampus, a brain region involved in cognitive processes. The hippocampus has high levels of leptin receptors (Ob-R) that participate in synaptic plasticity. This study examined the effect of maternal HFD during g...
journal_title:Nutritional neuroscience
pub_type: 信件
doi:10.1080/1028415X.2020.1728473
更新日期:2020-02-19 00:00:00
abstract:OBJECTIVES:Somatic symptoms are common in depressive disorder and are similar to sickness behaviors due to inflammatory activation after cytokine administration. Omega-3 polyunsaturated fatty acids (PUFAs) are natural anti-inflammatory agents and may reduce inflammation-induced behavioral changes. The aim of this study...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2015.1123378
更新日期:2017-06-01 00:00:00
abstract::Introduction: Obesity is a public health problem that is associated with cerebrovascular diseases, such as ischemic stroke. The coexistence of obesity with cerebral ischemia has been suggested to be considerably detrimental to the neurological system. Objective: Hence, in this study, we evaluated the long-term effects...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2020.1841482
更新日期:2020-11-08 00:00:00
abstract::Objective: The association between vitamin E supplementation and Alzheimer's disease (AD) was controversial because of conflicting data in the literature. This study was designed to systematically evaluate evidence about the efficacy of vitamin E supplementation not only on the risk but also on the progression of AD. ...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2019.1585506
更新日期:2021-01-01 00:00:00
abstract::Objective: Possible effects of the vagus inhibition and stimulation on the hypothalamic nuclei, myenteric plexes and the vagus nerve were investigated. Methods: The female rats divided to the inhibition (INH), stimulation (STI) and, sham (SHAM) groups were fed with high fat diet (including 40% of energy from animal fa...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2020.1809875
更新日期:2020-10-09 00:00:00
abstract::Phosphatidylserine (PS) is a phospholipid widely sold as a nutritional supplement. PS has been claimed to enhance neuronal membrane function and hence cognitive function, especially in the elderly. We report the results of a clinical trial of soybean-derived PS (S-PS) in aging subjects with memory complaints. Subjects...
journal_title:Nutritional neuroscience
pub_type: 临床试验,杂志文章
doi:10.1080/1028415x.2001.11747356
更新日期:2001-01-01 00:00:00
abstract::Cognitive and motor performance are critical in many circumstances and are impaired by sleep deprivation. We administered placebo, tyrosine 150 mg/kg, caffeine 300 mg/70 kg, phentermine 37.5 mg and D-amphetamine 20 mg at 15.30 h following overnight sleep deprivation and compare their effects on cognitive and motor per...
journal_title:Nutritional neuroscience
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/1028415031000120552
更新日期:2003-08-01 00:00:00
abstract::Mitochondrial decay due to oxidative damage is a contributor to brain aging and age-related neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD). One type of mitochondrial decay is oxidative modification of key mitochondrial enzymes. Enzyme dysfunction, that is due to poor binding ...
journal_title:Nutritional neuroscience
pub_type: 杂志文章,评审
doi:10.1080/10284150500047161
更新日期:2005-04-01 00:00:00