A high-fat diet during pregnancy impairs memory acquisition and increases leptin receptor expression in the hippocampus of rat offspring.


:A high-fat diet (HFD) during pregnancy influences the neurodevelopment of progeny, particularly in the hippocampus, a brain region involved in cognitive processes. The hippocampus has high levels of leptin receptors (Ob-R) that participate in synaptic plasticity. This study examined the effect of maternal HFD during gestation on Ob-R expression in the CA1 and CA3 hippocampal regions, and its relationship with spatial learning and memory in the offspring. We used 48 rat pups: 24 from dams fed a balanced diet (BD, 6.2% fat) and 24 from those fed an HFD (42% fat) during pregnancy. We recorded weight gain and food intake in each pup every day beginning on postnatal day 3 (PND 3). Memory acquisition was assessed on PND 28 and memory retention on PND 42 in the Morris water maze (MWM). Then, 12 pups per group were selected randomly and subjected to bioimpedance spectroscopy. The remaining offspring was perfused to determine Ob-R expression levels in the CA1 and CA3 hippocampal regions. Interestingly, HFD pups had significantly higher weight gain, food intake, and fat mass than BD offspring. Interestingly, the HFD group showed poor memory performance, which correlated with changes in the Ob-R expression in both hippocampal regions. These data indicate that maternal exposure to HFD impacts neurodevelopmental and cognitive functions of the offspring.


Nutr Neurosci


Nutritional neuroscience


Cortés-Álvarez NY,Vuelvas-Olmos CR,Pinto-González MF,Guzmán-Muñiz J,Gonzalez-Perez O,Moy-López NA




Has Abstract


2020-02-19 00:00:00








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    abstract::This study aimed to investigate the effect of a single injection of pilocarpine upon the phenomenon of cortical spreading depression (SD), in adult rats submitted to early malnutrition and/or to REM-sleep deprivation for 72h prior to the SD-recordings. The SD was recorded continuously for 3-4h in 13 well-nourished (W)...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: De Vasconcelos CA,De Oliveira JA,De Oliveira Costat LA,Guedes RC

    更新日期:2004-06-01 00:00:00

  • Analyzing data in which the outcome is time to an event part II: The presence of multiple covariates.

    abstract::In this article, the second of a series on the analysis of time to event data, we address the case in which multiple predictors (covariates) that may influence the time to an event are taken into account. The hazard function is introduced, and is given in a form useful for assessing the impact of multiple covariates o...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Mera R,Thompson HW,Prasad C

    更新日期:2003-04-01 00:00:00

  • Oral solution of fructose promotes SREBP-1c high-expression in the hypothalamus of Wistar rats.

    abstract::Objective: We evaluate whether the consumption of fructose for 8 weeks affects enzymes and transcription factors of the lipogenic and inflammatory pathways in the hypothalamus of Wistar rats. Methods: At 30 days, the animals were divided into groups: Control (C) and Fructose (F) and maintained with free access to feed...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Batista LO,Ramos VW,Rosas Fernández MA,Concha Vilca CM,Albuquerque KT

    更新日期:2019-09-01 00:00:00

  • Is the maturation of monosynaptic stretch reflex in rats affected by neonatal malnutrition?

    abstract::We compared the maturation of the monosynaptic stretch reflex in control rats and in rats submitted to neonatal malnutrition. Electrical stimulations of the sciatic nerve were applied in wakeful rats of different ages (21-90 days) to record, by surface electrodes, the maximal direct motor response (M(max)) or the maxi...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Freitas-Silva SR,Manhães-de-Castro R,Pérot C

    更新日期:2008-10-01 00:00:00

  • Contribution of spathulenol to the anti-nociceptive effects of Psidium guineense.

    abstract::Objectives: Araçá-verdadeiro is the popular name of Psidium guineense (Myrtaceae), whose fruits and leaves are used in Brazilian folk medicine for treatment of inflammation and pain. The focus of the present research was an investigation of the anti-nociceptive, and anti-inflammatory effects of the essential oil from ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Dos Santos E,Radai JAS,do Nascimento KF,Formagio ASN,de Matos Balsalobre N,Ziff EB,Castelon Konkiewitz E,Kassuya CAL

    更新日期:2020-09-11 00:00:00

  • Brain Nrf2 pathway, autophagy, and synaptic function proteins are modulated by a short-term fructose feeding in young and adult rats.

    abstract::Objectives: A strong rise of the fructose content in the human diet occurred in the last decade, as corn syrup is widely used as a sweetener for beverages and processed food. Since young people make a widespread consumption of added sugars, we evaluated the effects of a two weeks fructose-rich diet on brain redox home...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Spagnuolo MS,Bergamo P,Crescenzo R,Iannotta L,Treppiccione L,Iossa S,Cigliano L

    更新日期:2020-04-01 00:00:00

  • Effects of amylin on food intake and body weight via sympathetic innervation of the interscapular brown adipose tissue.

    abstract::Objective: Amylin acts on the lateral dorsal tegmental nucleus (LDT), resulting in anorexic and weight-loss effects and activates thermogenesis in the interscapular brown adipose tissue (IBAT). In addition, it induces neuronal nitric oxide synthase (nNOS) and choline acetyltransferase (ChAT)-mediated feeding. However,...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Fan K,Li Q,Pan D,Liu H,Li P,Hai R,Du C

    更新日期:2020-04-25 00:00:00

  • Analysis of electrocorticographic patterns in rats fed standard or hyperlipidic diets in a normal state or during status epilepticus.

    abstract:OBJECTIVE:The consumption of hyperlipidic diets has grown markedly in recent decades, and several studies have linked this consumption with the development of neurodegenerative diseases. Conversely, hyperlipidic diets have been used as an alternative therapy for refractory epilepsy. The purpose of this study was to eva...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Pessoa D,Cruz R,Machado B,Tenorio B,Nogueira R

    更新日期:2016-06-01 00:00:00

  • Mediterranean diet and stroke: objectives and design of the SUN project. Seguimiento Universidad de Navarra.

    abstract:PURPOSE:The Mediterranean diet has been postulated as a protective factor against different diseases including stroke. Thus, an epidemiological study in a Mediterranean country, such as Spain, focused on diet may offer new insights of the potential benefits of this nutritional pattern to prevent the onset of cerebrovas...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Martínez-González MA,Sanchez-Villegas A,De Irala J,Marti A,Martínez JA

    更新日期:2002-02-01 00:00:00

  • Improved cognitive-cerebral function in older adults with chromium supplementation.

    abstract::Insulin resistance is implicated in the pathophysiological changes associated with Alzheimer's disease, and pharmaceutical treatments that overcome insulin resistance improve memory function in subjects with mild cognitive impairment (MCI) and early Alzheimer's disease. Chromium (Cr) supplementation improves glucose d...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章,随机对照试验


    authors: Krikorian R,Eliassen JC,Boespflug EL,Nash TA,Shidler MD

    更新日期:2010-06-01 00:00:00

  • Crocin-protected malathion-induced spatial memory deficits by inhibiting TAU protein hyperphosphorylation and antiapoptotic effects.

    abstract::Organophosphorus compounds are widely used in agriculture. Epidemiological studies propose that pesticide exposure is a risk factor for Alzheimer's disease (AD), but the mechanisms are unclear. Here, we investigated the impact of malathion exposure on the cognitive ability and the underlying mechanisms in rats. Moreov...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Mohammadzadeh L,Abnous K,Razavi BM,Hosseinzadeh H

    更新日期:2020-03-01 00:00:00

  • Inhibitory effect of apelin-12 on nocturnal food intake in the rat.

    abstract::Apelin, the endogenous peptide ligand of the APJ receptor, is expressed in brain regions implicated in food and water intake. This study reports for the first time, the effect of apelin-12, one of the most potent apelin peptides, on spontaneous (nocturnal) feeding. Randomised intracerebroventricular injection of 1, 3 ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: O'Shea M,Hansen MJ,Tatemoto K,Morris MJ

    更新日期:2003-06-01 00:00:00

  • Modulation of brain insulin signaling in Alzheimer's disease: New insight on the protective role of green coffee bean extract.

    abstract::Objective: Alzheimer's disease (AD), a neurodegenerative disorder, involves brain insulin signaling cascades and insulin resistance (IR). Because of limited treatment options, new treatment strategies are mandatory. Green coffee bean extract (GCBE) was reported to attenuate IR and improve brain energy metabolism. We a...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Mohamed HE,Asker ME,Younis NN,Shaheen MA,Eissa RG

    更新日期:2020-01-01 00:00:00

  • Protection against brain tissues oxidative damage as a possible mechanism for the beneficial effects of Rosa damascena hydroalcoholic extract on scopolamine induced memory impairment in rats.

    abstract:OBJECTIVES:Hypnotic, analgesic, anticonvulsant, and antioxidant effects of Rosa damascena have been reported. This study, investigated the effect of R. damascena hydroalcoholic extract on memory performance in a scopolamine-induced memory impairment model. METHODS:The rats were divided into control group received just...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Mohammadpour T,Hosseini M,Naderi A,Karami R,Sadeghnia HR,Soukhtanloo M,Vafaee F

    更新日期:2015-10-01 00:00:00

  • Perinatal supplementation with omega-3 fatty acids corrects the aberrant social and cognitive traits observed in a genetic model of autism based on FMR1 deletion in rats.

    abstract::Background and objective: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder for which no treatments exist. Fragile X syndrome (FXS) is the most common form of inherited mental retardation and the most frequent monogenic cause of ASD. Given the lack of pharmacological treatments for ASD, increasin...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Schiavi S,Carbone E,Melancia F,Buzzelli V,Manduca A,Campolongo P,Pallottini V,Trezza V

    更新日期:2020-09-11 00:00:00

  • Adherence to a Mediterranean diet is associated with cognitive function in an older non-Mediterranean sample: findings from the Maine-Syracuse Longitudinal Study.

    abstract::Background: Adherence to a Mediterranean diet is associated with higher cognitive function and reduced risk of dementia in Mediterranean populations. However, few studies have investigated the association between Mediterranean diet adherence and cognition in populations outside of the Mediterranean basin. Furthermore,...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Wade AT,Elias MF,Murphy KJ

    更新日期:2019-08-21 00:00:00

  • Rich fatty acids diet of fish and olive oils modifies membrane properties in striatal rat synaptosomes.

    abstract::Background: Essential fatty acids (EFAs) and non-essential fatty acids (nEFAs) exert experimental and clinical neuroprotection in neurodegenerative diseases. The main EFAs, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), nEFAs, and oleic acid (OA) contained in olive and fish oils are inserted into the cell me...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Morales-Martínez A,Zamorano-Carrillo A,Montes S,El-Hafidi M,Sánchez-Mendoza A,Soria-Castro E,Martínez-Lazcano JC,Martínez-Gopar PE,Ríos C,Pérez-Severiano F

    更新日期:2021-01-01 00:00:00

  • The effect of vitamin D and calcium supplementation on inflammatory biomarkers, estradiol levels and severity of symptoms in women with postpartum depression: a randomized double-blind clinical trial.

    abstract::Objectives: Postpartum depression (PPD) is a major depressive disorder. Vitamin D deficiency may play a role in PPD pathogenesis. This study was designed to determine the effect of vitamin D and calcium supplementation on the severity of symptoms and some related inflammatory biomarkers in women with PPD.Materials and...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Amini S,Amani R,Jafarirad S,Cheraghian B,Sayyah M,Hemmati AA

    更新日期:2020-01-03 00:00:00

  • Depletion of dietary phytoestrogens reduces hippocampal plasticity and contextual fear memory stability in adult male mouse.

    abstract::Introduction: Phytoestrogens are non-steroidal estrogen analogues and are found primarily in soy products. They have received increasing attention as dietary supplements for estrogen deficiency and as modulators of endogenous estrogen functions, including cognition and emotion. In addition to modifying the levels of c...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Çalışkan G,Raza SA,Demiray YE,Kul E,Sandhu KV,Stork O

    更新日期:2019-12-09 00:00:00

  • Rosmarinic acid protects against chronic ethanol-induced learning and memory deficits in rats.

    abstract:OBJECTIVES:Ethanol consumption induces neurological disorders including cognitive dysfunction. Oxidative damage is considered a likely cause of cognitive deficits. We aimed to investigate the effects of rosmarinic acid (RA) in different doses for 30 days on chronic ethanol-induced cognitive dysfunction using the passiv...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Hasanein P,Seifi R,Hajinezhad MR,Emamjomeh A

    更新日期:2017-11-01 00:00:00

  • Vitamins: a nutritional intervention to modulate the Alzheimer's disease progression.

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    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Alam J

    更新日期:2020-10-01 00:00:00

  • Green tea and vitamin C ameliorate some neuro-functional and biochemical signs of arsenic toxicity in rats.

    abstract:BACKGROUND/OBJECTIVES:Nervous system damage is one of the consequences of oral exposure to waterborne inorganic arsenic. In this work, the role of oxidative status in the neurotoxicity of arsenic and the possible role of two foodborne antioxidants in ameliorating arsenic-related oxidative stress were investigated. MET...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Sárközi K,Papp A,Horváth E,Máté Z,Ferencz Á,Hermesz E,Krisch J,Paulik E,Szabó A

    更新日期:2016-01-01 00:00:00

  • Coenzyme Q10 supplementation improves acute outcomes of stroke in rats pretreated with atorvastatin.

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    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Nasoohi S,Simani L,Khodagholi F,Nikseresht S,Faizi M,Naderi N

    更新日期:2019-04-01 00:00:00

  • Naltrexone antagonism of morphine antinociception in sucrose- and chow-fed rats.

    abstract::Rats given long-term access to a palatable sucrose solution are more sensitive to (1) the analgesic potency of morphine and (2) the anorectic actions of naltrexone. In the present experiment, the ability of naltrexone to antagonize the antinociceptive properties of morphine was examined in sucrose- and chow-fed rats. ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: D'Anci KE,Kanarek RB

    更新日期:2004-02-01 00:00:00

  • Inhibition of hormonal and behavioral effects of stress by tryptophan in rats.

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    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Gul S,Saleem D,Haleem MA,Haleem DJ

    更新日期:2019-06-01 00:00:00

  • Sulfur amino acid deficiency depresses brain glutathione concentration.

    abstract::Dietary sulfur amino acid content is a major determinant of glutathione concentration in some tissues. We examined whether brain glutathione (GSH), a key component of antioxidant defense important for minimizing ischemic injury, was also responsive to short-term sulfur amino acid deficiency. Female Long-Evans adult ra...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Paterson PG,Lyon AW,Kamencic H,Andersen LB,Juurlink BH

    更新日期:2001-01-01 00:00:00

  • Vitamin B12-responsive neuropathies: A case series.

    abstract:OBJECTIVES:Neuropathies often accompany vitamin B12 deficiency. Since many neuropathies are linked to oxidative stress and since B12 has both antioxidant and neurotrophic properties, B12 may also be effective treatment in non-deficient subjects. Thus, the characteristics and predictors of B12-responsive neuropathies an...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Solomon LR

    更新日期:2016-05-01 00:00:00

  • Effects of vitamin E supplementation on the risk and progression of AD: a systematic review and meta-analysis.

    abstract::Objective: The association between vitamin E supplementation and Alzheimer's disease (AD) was controversial because of conflicting data in the literature. This study was designed to systematically evaluate evidence about the efficacy of vitamin E supplementation not only on the risk but also on the progression of AD. ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Wang W,Li J,Zhang H,Wang X,Zhang X

    更新日期:2021-01-01 00:00:00

  • Mild experimental ketosis increases brain uptake of 11C-acetoacetate and 18F-fluorodeoxyglucose: a dual-tracer PET imaging study in rats.

    abstract::Brain glucose and ketone uptake was investigated in Fisher rats subjected to mild experimental ketonemia induced by a ketogenic diet (KD) or by 48 hours fasting (F). Two tracers were used, (11)C-acetoacetate ((11)C-AcAc) for ketones and (18)F-fluorodeoxyglucose for glucose, in a dual-tracer format for each animal. Thu...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Pifferi F,Tremblay S,Croteau E,Fortier M,Tremblay-Mercier J,Lecomte R,Cunnane SC

    更新日期:2011-03-01 00:00:00

  • Autism and Schizophrenia: Intestinal Disorders.

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    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Cade R,Privette M,Fregly M,Rowland N,Sun Z,Zele V,Wagemaker H,Edelstein C

    更新日期:2000-01-01 00:00:00