A high-fat diet during pregnancy impairs memory acquisition and increases leptin receptor expression in the hippocampus of rat offspring.


:A high-fat diet (HFD) during pregnancy influences the neurodevelopment of progeny, particularly in the hippocampus, a brain region involved in cognitive processes. The hippocampus has high levels of leptin receptors (Ob-R) that participate in synaptic plasticity. This study examined the effect of maternal HFD during gestation on Ob-R expression in the CA1 and CA3 hippocampal regions, and its relationship with spatial learning and memory in the offspring. We used 48 rat pups: 24 from dams fed a balanced diet (BD, 6.2% fat) and 24 from those fed an HFD (42% fat) during pregnancy. We recorded weight gain and food intake in each pup every day beginning on postnatal day 3 (PND 3). Memory acquisition was assessed on PND 28 and memory retention on PND 42 in the Morris water maze (MWM). Then, 12 pups per group were selected randomly and subjected to bioimpedance spectroscopy. The remaining offspring was perfused to determine Ob-R expression levels in the CA1 and CA3 hippocampal regions. Interestingly, HFD pups had significantly higher weight gain, food intake, and fat mass than BD offspring. Interestingly, the HFD group showed poor memory performance, which correlated with changes in the Ob-R expression in both hippocampal regions. These data indicate that maternal exposure to HFD impacts neurodevelopmental and cognitive functions of the offspring.


Nutr Neurosci


Nutritional neuroscience


Cortés-Álvarez NY,Vuelvas-Olmos CR,Pinto-González MF,Guzmán-Muñiz J,Gonzalez-Perez O,Moy-López NA




Has Abstract


2020-02-19 00:00:00








  • Is the maturation of monosynaptic stretch reflex in rats affected by neonatal malnutrition?

    abstract::We compared the maturation of the monosynaptic stretch reflex in control rats and in rats submitted to neonatal malnutrition. Electrical stimulations of the sciatic nerve were applied in wakeful rats of different ages (21-90 days) to record, by surface electrodes, the maximal direct motor response (M(max)) or the maxi...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Freitas-Silva SR,Manhães-de-Castro R,Pérot C

    更新日期:2008-10-01 00:00:00

  • Holothuria scabra extracts exhibit anti-Parkinson potential in C. elegans: A model for anti-Parkinson testing.

    abstract:OBJECTIVES:Parkinson's disease (PD) is associated with aggregation of α-synuclein and selective death of dopaminergic (DA) neurons in the substantia nigra, thereby leading to cognitive and motor impairments. Nowadays, the drugs commonly used for PD treatment, such as levodopa, provide only symptomatic relief. Therefore...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Chalorak P,Jattujan P,Nobsathian S,Poomtong T,Sobhon P,Meemon K

    更新日期:2018-07-01 00:00:00

  • Vitamins: a nutritional intervention to modulate the Alzheimer's disease progression.

    abstract::Background: Alzheimer's disease is known as one of the fastest growing lethal diseases worldwide where we have limited and undesired ways for regulating its pathological progress. Now-a-days, nutritional compounds have been using to treat several brain disorders and one of them; vitamins were strongly reported to comb...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Alam J

    更新日期:2020-10-01 00:00:00

  • Advantageous effect of theanine intake on cognition.

    abstract::Theanine, γ-glutamylethylamide, is one of the major amino acid components in green tea. On the basis of the preventive effect of theanine intake after weaning on stress-induced impairment of recognition memory, the advantageous effect of theanine intake on recognition memory was examined in young rats, which were fed ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Tamano H,Fukura K,Suzuki M,Sakamoto K,Yokogoshi H,Takeda A

    更新日期:2014-11-01 00:00:00

  • A Saturated-Fat Diet during Development Alters Dendritic Growth in Mouse Brain.

    abstract::The objective of this study was to determine whether an essential fatty acid (EFA)-deficient diet (saturated fat) fed during development would alter the pattern of dendritic growth in pyramidal neurons of mouse occipital cortex. Pregnant and lactating mice were fed either a saturated fat or control diet throughout pre...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Wainwright PE,Bulman-Fleming MB,Lévesque S,Mutsaers L,McCutcheon D

    更新日期:1998-01-01 00:00:00

  • Interactive Effects of Neurochemicals on Ingestive Behavior.

    abstract::Most previous research has focused on the effects of single neurotransmitters and neuropeptides on ingestive behavior. An important next step in the advancement of the science of ingestive behavior is to gain an understanding of how these different systems interact with one another. The present article is designed as ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Roth JD,Rowland NE

    更新日期:2000-01-01 00:00:00

  • Dietary choline during periadolescence attenuates cognitive damage caused by neonatal maternal separation in male rats.

    abstract:OBJECTIVES:Choline (Ch) is an essential nutrient that acts as a cognitive facilitator when administered during perinatal periods, and it has been recognised as a 'pharmacological' agent that can ease cognitive dysfunctions provoked by exposure to damaging stimuli during early developmental stages. The aim of the presen...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Moreno Gudiño H,Carías Picón D,de Brugada Sauras I

    更新日期:2017-07-01 00:00:00

  • Perinatal supplementation with omega-3 fatty acids corrects the aberrant social and cognitive traits observed in a genetic model of autism based on FMR1 deletion in rats.

    abstract::Background and objective: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder for which no treatments exist. Fragile X syndrome (FXS) is the most common form of inherited mental retardation and the most frequent monogenic cause of ASD. Given the lack of pharmacological treatments for ASD, increasin...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Schiavi S,Carbone E,Melancia F,Buzzelli V,Manduca A,Campolongo P,Pallottini V,Trezza V

    更新日期:2020-09-11 00:00:00

  • The natural xanthone alpha-mangostin reduces oxidative damage in rat brain tissue.

    abstract::The antiperoxidative properties of alpha-mangostin, a xanthone isolated from mangosteen fruit, were tested for the first time in nerve tissue exposed to different toxic insults. Two reliable biological preparations (rat brain homogenates and synaptosomal P2 fractions) were exposed to the toxic actions of a free radica...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Márquez-Valadez B,Lugo-Huitrón R,Valdivia-Cerda V,Miranda-Ramírez LR,Pérez-De La Cruz V,González-Cuahutencos O,Rivero-Cruz I,Mata R,Santamaría A,Pedraza-Chaverrí J

    更新日期:2009-02-01 00:00:00

  • Sulfur amino acid deficiency depresses brain glutathione concentration.

    abstract::Dietary sulfur amino acid content is a major determinant of glutathione concentration in some tissues. We examined whether brain glutathione (GSH), a key component of antioxidant defense important for minimizing ischemic injury, was also responsive to short-term sulfur amino acid deficiency. Female Long-Evans adult ra...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Paterson PG,Lyon AW,Kamencic H,Andersen LB,Juurlink BH

    更新日期:2001-01-01 00:00:00

  • Beneficial effects of a protein free, high carbohydrate meal on rat coping behavior and neurotransmitter levels during heat stress.

    abstract::This study examined effects of a single protein-free (PROT-free), high carbohydrate meal (0% protein, 82% carbohydrate) or control meal (20% protein, 62% carbohydrate) on coping behavior and neurotransmitter levels of male Fischer 344 rats. Meals varying in protein/carbohydrate ratio differentially affect transport of...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Yeghiayan SK,Georgelis JH,Maher TJ,Lieberman HR

    更新日期:2004-10-01 00:00:00

  • Perspectives from the symposium: The role of nutrition in infant and toddler brain and behavioral development.

    abstract::This symposium examined current trends in neuroscience and developmental psychology as they apply to assessing the effects of nutrients on brain and behavioral development of 0-6-year-olds. Although the spectrum of nutrients with brain effects has not changed much in the last 25 years, there has been an explosion in n...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Rosales FJ,Zeisel SH

    更新日期:2008-06-01 00:00:00

  • Protective effects of vitamin D on neurophysiologic alterations in brain aging: role of brain-derived neurotrophic factor (BDNF).

    abstract::Background/aim: Vitamin D has been hypothesized to be main regulator of the aging rate, alongside evidences support its role in neuroprotection. However, data about the protective role of vitamin D against neurophysiologic alterations associated with brain aging is limited. This study investigated the possible protect...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Khairy EY,Attia MM

    更新日期:2019-09-16 00:00:00

  • Inhibitory effect of apelin-12 on nocturnal food intake in the rat.

    abstract::Apelin, the endogenous peptide ligand of the APJ receptor, is expressed in brain regions implicated in food and water intake. This study reports for the first time, the effect of apelin-12, one of the most potent apelin peptides, on spontaneous (nocturnal) feeding. Randomised intracerebroventricular injection of 1, 3 ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: O'Shea M,Hansen MJ,Tatemoto K,Morris MJ

    更新日期:2003-06-01 00:00:00

  • Low dietary protein is associated with an increase in food intake and a decrease in the in vitro release of radiolabeled glutamate and GABA from the lateral hypothalamus.

    abstract::Moderately low-protein diets lead to a rapid increase in food intake and body fat. The increase in feeding is associated with a decrease in the concentration of serum urea nitrogen, suggesting that the low-protein-induced increase in food intake may be related to the decreased metabolism of nitrogen from amino acids. ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: White BD,Du F,Higginbotham DA

    更新日期:2003-12-01 00:00:00

  • Nutrition status survey of type 2 and 3 spinal muscular atrophy in Chinese population.

    abstract:OBJECTIVE:To evaluate the nutritional status of children with SMA types II and III in a Chinese population. METHODS:We performed a retrospective medical record review of prospectively collected data from children with SMA types II and III in a single centre. We analysed data including clinical parameters, anthropometr...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Zhou Y,Chen J,Gong X,Lu Z,Hua H,Zhu X,Shi P,Li X,Zhou S,Wang Y,Qian T

    更新日期:2021-01-23 00:00:00

  • Response to Energy Dilution in the Short Term: Evidence of Nutritional Wisdom in Young Children?

    abstract::Young children respond to energy dilution achieved using fat or sugar substitutes by compensating for reduced energy within a single meal. The ability to respond to energy dilution in the short term may diminish with age, since adults do not reliably demonstrate accurate caloric compensation in the short term. Two exp...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Hetherington MM,Wood C,Lyburn SC

    更新日期:2000-01-01 00:00:00

  • Is vagal stimulation or inhibition benefit on the regulation of the stomach brain axis in obesity?

    abstract::Objective: Possible effects of the vagus inhibition and stimulation on the hypothalamic nuclei, myenteric plexes and the vagus nerve were investigated. Methods: The female rats divided to the inhibition (INH), stimulation (STI) and, sham (SHAM) groups were fed with high fat diet (including 40% of energy from animal fa...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Alkan I,Altunkaynak BZ,Kivrak EG,Kaplan AA,Arslan G

    更新日期:2020-10-09 00:00:00

  • Ghrelin as a prominent endocrine factor in stress-induced obesity.

    abstract::Objectives: Ghrelin acts on a variety of central- and peripheral organs causing an orexigenic effect, conclusively followed by increased caloric intake. Recent studies have indicated that ghrelin's function as an orexigenic agent does not entirely reflect the full functional properties of the peptide. Specifically, gh...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: van Loenen MR,Geenen B,Arnoldussen IAC,Kiliaan AJ

    更新日期:2020-12-29 00:00:00

  • Lactation in large litters influences anxiety, memory, and spreading depression in adult male rats that were chronically subjected to a non-convulsive pilocarpine dose.

    abstract::Objectives: Unfavorable lactation influences brain excitability and behavioral reactions in adults. Administration early in life of the cholinergic agonist, pilocarpine, even at non-convulsive doses, alters the brain excitability-related phenomenon known as cortical spreading depression (CSD), and produce anxiogenic-l...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Benevides RDL,de-Lima SMV,Chagas CL,de Lima CF,Abadie-Guedes R,Guedes RCA

    更新日期:2020-09-11 00:00:00

  • Modulation of brain insulin signaling in Alzheimer's disease: New insight on the protective role of green coffee bean extract.

    abstract::Objective: Alzheimer's disease (AD), a neurodegenerative disorder, involves brain insulin signaling cascades and insulin resistance (IR). Because of limited treatment options, new treatment strategies are mandatory. Green coffee bean extract (GCBE) was reported to attenuate IR and improve brain energy metabolism. We a...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Mohamed HE,Asker ME,Younis NN,Shaheen MA,Eissa RG

    更新日期:2020-01-01 00:00:00

  • Pseudotumor cerebri in pediatric age: role of obesity in the management of neurological impairments.

    abstract::Pseudotumor cerebri occurs quite rarely in the pediatric population and its clinical features differ from adults in many ways. Intracranial hypertension with papilledema should obviously be treated promptly to avoid permanent visual damage, but various more or less invasive options have been proposed over the years, f...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Marton E,Feletti A,Mazzucco GM,Longatti P

    更新日期:2008-02-01 00:00:00

  • Chronic Diazepam Administration Failed to Induce Tolerance and Withdrawal Syndrome in Perinatally Undernourished Female Rats as Measured in the Open Field Drink Test.

    abstract::Adult female rats, receiving a low protein diet at perinatal age and then recovered with balanced chow (D rats), were evaluated in the Open Field Drink Test (OFDT), after different acute and chronic treatments with benzodiazepines (BZD) ligands, as compared with control (C) female rats. Control and D rats showed simil...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Borghese CM,Córdoba NE,Arolfo MP,Orsingher OA

    更新日期:1998-01-01 00:00:00

  • Association of dietary patterns with systemic inflammation, quality of life, disease severity, relapse rate, severity of fatigue and anthropometric measurements in MS patients.

    abstract::Background: Multiple sclerosis (MS) is associated with changes in quality of life, disability, fatigue and anthropometric measurements. The important relationship of dietary patterns with such clinical manifestations was not completely investigated. Aims: The goal of this study was to define the dietary patterns and t...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Moravejolahkami AR,Paknahad Z,Chitsaz A

    更新日期:2020-12-01 00:00:00

  • Vitamin D metabolites, D3 and D2, and their independent associations with depression symptoms among adults in the United States.

    abstract::Background: The two metabolites of vitamin D; serum 25-hydroxyvitamin D3 (25(OH)D3) and D2 (25(OH)D2), and their independent roles in mood regulation are unexplored. This study aims to examine 25(OH)D3 and 25(OH)D2 and their interplay with depression symptoms. Materials and Methods: Utilizing data from the U.S. Nation...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Bigman G

    更新日期:2020-07-20 00:00:00

  • Green tea and vitamin C ameliorate some neuro-functional and biochemical signs of arsenic toxicity in rats.

    abstract:BACKGROUND/OBJECTIVES:Nervous system damage is one of the consequences of oral exposure to waterborne inorganic arsenic. In this work, the role of oxidative status in the neurotoxicity of arsenic and the possible role of two foodborne antioxidants in ameliorating arsenic-related oxidative stress were investigated. MET...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Sárközi K,Papp A,Horváth E,Máté Z,Ferencz Á,Hermesz E,Krisch J,Paulik E,Szabó A

    更新日期:2016-01-01 00:00:00

  • Relationships between Pregnancy and Vitamin B-6 Nutriture on Brain 3-Hydroxykynurenine Concentrations in Mice.

    abstract::The kynurenine (KYN) pathway of tryptophan metabolism produces several neuroactive metabolites, including 3-hydroxykynurenine (3HK). The pathway is subject to regulation by a number of effectors including pregnancy and availability of vitamin B-6. Vitamin B-6 depleted humans and animals excrete abnormally high concent...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: van de Kamp JL,Smolen A

    更新日期:2000-01-01 00:00:00

  • Supplements, nutrition, and alternative therapies for the treatment of traumatic brain injury.

    abstract::Studies using traditional treatment strategies for mild traumatic brain injury (TBI) have produced limited clinical success. Interest in treatment for mild TBI is at an all time high due to its association with the development of chronic traumatic encephalopathy and other neurodegenerative diseases, yet therapeutic op...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章,评审


    authors: Lucke-Wold BP,Logsdon AF,Nguyen L,Eltanahay A,Turner RC,Bonasso P,Knotts C,Moeck A,Maroon JC,Bailes JE,Rosen CL

    更新日期:2018-02-01 00:00:00

  • The Effect of Centrally Administered Glibenclamide, Tolbutamide and Diazoxide on Feeding in Rats.

    abstract::While there are many theories on the control of feeding behavior that emphasize a role for energy substrates and their metabolism, the mechanism that couples changes in energy substrate supply and metabolism to alterations in food intake remains unclear. The purpose of the present project was to investigate the possib...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Bounds JK,Adloo AA,Harp PR,Olivier K,Roane DS

    更新日期:1999-01-01 00:00:00

  • A novel insight on chronic AlCl3 neurotoxicity through IL-6 and GFAP expressions: modulating effect of functional food fenugreek seeds.

    abstract:OBJECTIVE:This study was designed to review the effect of chronic aluminium exposure on interleukin-6 (IL-6) secretion in the posterior brain and test the putative modulating effect of fenugreek seeds. METHODS:Female Wistar rats were divided into four groups: control; AlCl3 during 5 months (500 mg/kg body weight, intr...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章


    authors: Belaïd-Nouira Y,Bakhta H,Samoud S,Trimech M,Haouas Z,Ben Cheikh H

    更新日期:2013-09-01 00:00:00