Fat rather than sugar diet leads to binge-type eating, anticipation, effort behavior and activation of the corticolimbic system.

Abstract:

:ABSTRACTObjectives: One factor contributing to the development of obesity is overeating palatable food. The palatability of food is driven by specific energy yielding combinations and flavor profiles that may contribute to its overconsumption. In rodents, restricted access to palatable food (PF) is a strong stimulus to trigger binge-type eating behavior (BTE), food anticipatory activity (FAA), effort behaviors and withdrawal symptoms. This is accompanied by plastic changes in corticolimbic areas associated with motivation and reward responses. Palatable food contains mainly a mixture of fat and sugar, thus, the contribution of each macronutrient for the behavioral and neuronal changes is unclear. Methods: In this study, Wistar rats were exposed to restricted access to 50% fat rich diet (FRD) or 50% sugar rich diet (SRD) in order to compare the intensity of BTE, FAA, effort behaviors and withdrawal responses. Results: In corticolimbic areas, c-Fos activation and ΔFosB accumulation were evaluated. After an acute exposition, rats ate more SRD than FRD, but FDR stimulated higher c-Fos. After chronic administration, the FDR group exhibited higher levels of BTE and FAA; this was associated with higher c-Fos and accumulation of ΔFosB in the corticolimbic system. Similar effects in the FRD group were observed after one week of withdrawal. Discussion: Present data indicate that the fat rich diet is a stronger stimulus than the sugar rich diet for the development of wanting behavior for reward and the underlying plastic changes in the corticolimbic system. The differential effects may be due to the differing caloric density of the diets.

journal_name

Nutr Neurosci

journal_title

Nutritional neuroscience

authors

Espitia-Bautista E,Escobar C

doi

10.1080/1028415X.2019.1651104

subject

Has Abstract

pub_date

2019-08-16 00:00:00

pages

1-12

eissn

1028-415X

issn

1476-8305

pub_type

杂志文章
  • Spirulina and C-phycocyanin reduce cytotoxicity and inflammation-related genes expression of microglial cells.

    abstract:OBJECTIVE:Our aim was to investigate the effects of Spirulina on BV-2 microglial cell cytotoxicity and inflammatory genes expression. METHODS:BV-2 microglial cells were treated with lipopolysaccharide (LPS) (1 µg/ml) and various concentrations of Spirulina platensis water extract or its active component (C-phycocyanin...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/1476830512Y.0000000020

    authors: Chen JC,Liu KS,Yang TJ,Hwang JH,Chan YC,Lee IT

    更新日期:2012-11-01 00:00:00

  • Nutrition status survey of type 2 and 3 spinal muscular atrophy in Chinese population.

    abstract:OBJECTIVE:To evaluate the nutritional status of children with SMA types II and III in a Chinese population. METHODS:We performed a retrospective medical record review of prospectively collected data from children with SMA types II and III in a single centre. We analysed data including clinical parameters, anthropometr...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2020.1871212

    authors: Zhou Y,Chen J,Gong X,Lu Z,Hua H,Zhu X,Shi P,Li X,Zhou S,Wang Y,Qian T

    更新日期:2021-01-23 00:00:00

  • Ghrelin as a prominent endocrine factor in stress-induced obesity.

    abstract::Objectives: Ghrelin acts on a variety of central- and peripheral organs causing an orexigenic effect, conclusively followed by increased caloric intake. Recent studies have indicated that ghrelin's function as an orexigenic agent does not entirely reflect the full functional properties of the peptide. Specifically, gh...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2020.1863740

    authors: van Loenen MR,Geenen B,Arnoldussen IAC,Kiliaan AJ

    更新日期:2020-12-29 00:00:00

  • Association between poor nutritional status and severe depression in Korean cerebral infarction patients.

    abstract:OBJECTIVE:The purpose of this study was to assess the association between cerebral infarction (CI), nutritional status, and depression. METHODS:Subjects with and without CI (n = 146; 73 CI vs. 73 non-CI) were recruited from Kyung Hee University Medical Center (Seoul, Korea) and were matched according to age and gende...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/1476830511Y.0000000023

    authors: Lim HJ,Choue R

    更新日期:2012-01-01 00:00:00

  • Feeding induced by increasing doses of neuropeptide Y: dual effect on hypothalamic serotonin release in normal rats.

    abstract::Endogenous neuropeptide Y (NPY) levels increase during fasting and before dark onset in rats. The feeding that follows these states elicits the release of serotonin in the lateral hypothalamus (LH), as part of the physiological mechanisms controlling satiety. With the hypothesis that exogenous NPY-induced feeding shou...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/10284150400012794

    authors: Mori RC,Telles MM,Guimarães RB,Novo NF,Juliano Y,Nascimento CM,Ribeiro EB

    更新日期:2004-08-01 00:00:00

  • Modulation of brain insulin signaling in Alzheimer's disease: New insight on the protective role of green coffee bean extract.

    abstract::Objective: Alzheimer's disease (AD), a neurodegenerative disorder, involves brain insulin signaling cascades and insulin resistance (IR). Because of limited treatment options, new treatment strategies are mandatory. Green coffee bean extract (GCBE) was reported to attenuate IR and improve brain energy metabolism. We a...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2018.1468535

    authors: Mohamed HE,Asker ME,Younis NN,Shaheen MA,Eissa RG

    更新日期:2020-01-01 00:00:00

  • Altered Fos immunoreactivity in the hypothalamus after glucose administration in pre- and post-weaning malnourished rats.

    abstract::The present study explored the effects of malnutrition and nutritional rehabilitation on the response to glucose in hypothalamic nuclei involved in metabolic homeostasis. Male Wistar rats were malnourished during gestation-lactation (MGL) or at weaning to 55 days (MPW). Two groups of rats were rehabilitated with a bal...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/147683010X12611460764246

    authors: Miñana-Solis Mdel C,Angeles-Castellanos M,Buijs RM,Escobar C

    更新日期:2010-08-01 00:00:00

  • Moderate Alcohol Intake: Behavioral and Neurochemical Correlates in Rats.

    abstract::A debate is open in the literature concerning the safety of low (dietary) versus high (intoxicating or addicting) alcohol consumption. Epidemiological data do indeed suggest that moderate ethanol intake may have beneficial effects, at least at cardiovascular level. On the other hand there are few data on the effect of...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.1998.11747224

    authors: Battaini F,Pascale A,Ancona DM,Cagiano R,Cuomo V,Govoni S

    更新日期:1998-01-01 00:00:00

  • Inhibition of hormonal and behavioral effects of stress by tryptophan in rats.

    abstract:OBJECTIVES:Stress in known to alter hormonal systems. Pharmacological doses of tryptophan, the essential amino acid precursor of serotonin, increase circulating leptin and decrease ghrelin in normal healthy adults. Because systemically injected leptin inhibits stress-induced behavioral deficits and systemically injecte...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2017.1395551

    authors: Gul S,Saleem D,Haleem MA,Haleem DJ

    更新日期:2019-06-01 00:00:00

  • Rich fatty acids diet of fish and olive oils modifies membrane properties in striatal rat synaptosomes.

    abstract::Background: Essential fatty acids (EFAs) and non-essential fatty acids (nEFAs) exert experimental and clinical neuroprotection in neurodegenerative diseases. The main EFAs, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), nEFAs, and oleic acid (OA) contained in olive and fish oils are inserted into the cell me...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2019.1584692

    authors: Morales-Martínez A,Zamorano-Carrillo A,Montes S,El-Hafidi M,Sánchez-Mendoza A,Soria-Castro E,Martínez-Lazcano JC,Martínez-Gopar PE,Ríos C,Pérez-Severiano F

    更新日期:2021-01-01 00:00:00

  • Perinatal supplementation with omega-3 fatty acids corrects the aberrant social and cognitive traits observed in a genetic model of autism based on FMR1 deletion in rats.

    abstract::Background and objective: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder for which no treatments exist. Fragile X syndrome (FXS) is the most common form of inherited mental retardation and the most frequent monogenic cause of ASD. Given the lack of pharmacological treatments for ASD, increasin...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2020.1819107

    authors: Schiavi S,Carbone E,Melancia F,Buzzelli V,Manduca A,Campolongo P,Pallottini V,Trezza V

    更新日期:2020-09-11 00:00:00

  • Relationships between Pregnancy and Vitamin B-6 Nutriture on Brain 3-Hydroxykynurenine Concentrations in Mice.

    abstract::The kynurenine (KYN) pathway of tryptophan metabolism produces several neuroactive metabolites, including 3-hydroxykynurenine (3HK). The pathway is subject to regulation by a number of effectors including pregnancy and availability of vitamin B-6. Vitamin B-6 depleted humans and animals excrete abnormally high concent...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2000.11747309

    authors: van de Kamp JL,Smolen A

    更新日期:2000-01-01 00:00:00

  • Evaluation of the antidepressant- and anxiolytic-like effects of a hydrophilic extract from the green seaweed Ulva sp. in rats.

    abstract:OBJECTIVES:The green seaweed Ulva sp. contains a large amount of ulvans, a family of sulphated polysaccharides. The present study was designed to investigate in rats the antidepressant- and anxiolytic-like effects of a hydrophilic extract of Ulva sp. (MSP) containing about 45% of ulvans. METHODS:After a 14-day adminis...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2016.1276704

    authors: Violle N,Rozan P,Demais H,Nyvall Collen P,Bisson JF

    更新日期:2018-05-01 00:00:00

  • Mediterranean diet and stroke: objectives and design of the SUN project. Seguimiento Universidad de Navarra.

    abstract:PURPOSE:The Mediterranean diet has been postulated as a protective factor against different diseases including stroke. Thus, an epidemiological study in a Mediterranean country, such as Spain, focused on diet may offer new insights of the potential benefits of this nutritional pattern to prevent the onset of cerebrovas...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/10284150290007047

    authors: Martínez-González MA,Sanchez-Villegas A,De Irala J,Marti A,Martínez JA

    更新日期:2002-02-01 00:00:00

  • Brain Nrf2 pathway, autophagy, and synaptic function proteins are modulated by a short-term fructose feeding in young and adult rats.

    abstract::Objectives: A strong rise of the fructose content in the human diet occurred in the last decade, as corn syrup is widely used as a sweetener for beverages and processed food. Since young people make a widespread consumption of added sugars, we evaluated the effects of a two weeks fructose-rich diet on brain redox home...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2018.1501532

    authors: Spagnuolo MS,Bergamo P,Crescenzo R,Iannotta L,Treppiccione L,Iossa S,Cigliano L

    更新日期:2020-04-01 00:00:00

  • A Saturated-Fat Diet during Development Alters Dendritic Growth in Mouse Brain.

    abstract::The objective of this study was to determine whether an essential fatty acid (EFA)-deficient diet (saturated fat) fed during development would alter the pattern of dendritic growth in pyramidal neurons of mouse occipital cortex. Pregnant and lactating mice were fed either a saturated fat or control diet throughout pre...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.1998.11747212

    authors: Wainwright PE,Bulman-Fleming MB,Lévesque S,Mutsaers L,McCutcheon D

    更新日期:1998-01-01 00:00:00

  • Blueberry extract as a potential pharmacological tool for preventing depressive-like behavior and neurochemical dysfunctions in mice exposed to lipopolysaccharide.

    abstract:OBJECTIVE:Major depressive disorder is a debilitating and recurrent psychiatric disorder. Blueberries have several biological properties, including neuroprotective effects, through antioxidant and anti-inflammatory actions. The aim of this study was to evaluate the effect of blueberry extract on depressive-like behavio...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2020.1819104

    authors: Spohr L,Luduvico KP,Soares MSP,Bona NP,Oliveira PS,de Mello JE,Alvez FL,Teixeira FC,Felix AOC,Stefanello FM,Spanevello RM

    更新日期:2020-09-21 00:00:00

  • Is vagal stimulation or inhibition benefit on the regulation of the stomach brain axis in obesity?

    abstract::Objective: Possible effects of the vagus inhibition and stimulation on the hypothalamic nuclei, myenteric plexes and the vagus nerve were investigated. Methods: The female rats divided to the inhibition (INH), stimulation (STI) and, sham (SHAM) groups were fed with high fat diet (including 40% of energy from animal fa...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2020.1809875

    authors: Alkan I,Altunkaynak BZ,Kivrak EG,Kaplan AA,Arslan G

    更新日期:2020-10-09 00:00:00

  • Organization of olfactory glomeruli in neonatally undernourished rats.

    abstract::Newborn rats maintain mother-litter bonds by using olfactory signals. At birth, units in the olfactory glomeruli (OG) are immature and vulnerable to noxious epigenetic factors like undernutrition. Because little is known about the effects of neonatal undernutrition upon the OG morphological organization, different OG ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/10284150500506042

    authors: Frias C,Torrero C,Regalado M,Salas M

    更新日期:2006-02-01 00:00:00

  • Differential Effects of Prenatal Protein Malnutrition and Prenatal Cocaine on Radial Arm Maze Performance in Adult Male Rats.

    abstract::The effects of prenatal cocaine and protein malnutrition were examined on acquisition of the radial arm maze in adult male Sprague-Dawley rats whose mothers were provided with a 6% casein, a 25% casein or a standard chow diet and cocaine (30mg/kg) or saline injections beginning 5 weeks prior to mating and continuing t...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.1999.11747269

    authors: Shumsky JS,Shultz PL,Galler JR,Tonkiss J

    更新日期:1999-01-01 00:00:00

  • Iodine Deficiency and the Brain.

    abstract::The effects of iodine deficiency on growth and development are known as the iodine deficiency disorders (IDDs). Most common is goitre at all ages, but most significant are the effects on brain development during pregnancy. The major effect of iodine deficiency is the clinical syndrome of endemic cretinism characterise...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.1999.11747292

    authors: Hetzel BS

    更新日期:1999-01-01 00:00:00

  • Inositol and Ginkgo biloba as Adjuncts in Chronic Depression: Case Report.

    abstract::The treatment of resistant depression has involved the use of various adjuncts in addition to the antidepressant, such as lithium or liothyronine (T3). This case report describes a woman with a history of chronic depression (dysthymic disorder), unresponsive to a number of traditional antidepressants, who was treated ...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.1998.11747241

    authors: Vadnal R

    更新日期:1998-01-01 00:00:00

  • Short-term effects of espresso coffee on heart rate variability and blood pressure in habitual and non-habitual coffee consumers--a randomized crossover study.

    abstract:OBJECTIVE:Coffee is one of the most widely consumed beverages worldwide. Aim of this study was to investigate short-term effects of espresso coffee on heart rate variability (HRV), a marker of vagal activity, in healthy habitual and non-habitual coffee consumers. METHODS:Seventy-seven healthy subjects (38 habitual and...

    journal_title:Nutritional neuroscience

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1179/1476830515Y.0000000018

    authors: Zimmermann-Viehoff F,Thayer J,Koenig J,Herrmann C,Weber CS,Deter HC

    更新日期:2016-05-01 00:00:00

  • Analysis of electrocorticographic patterns in rats fed standard or hyperlipidic diets in a normal state or during status epilepticus.

    abstract:OBJECTIVE:The consumption of hyperlipidic diets has grown markedly in recent decades, and several studies have linked this consumption with the development of neurodegenerative diseases. Conversely, hyperlipidic diets have been used as an alternative therapy for refractory epilepsy. The purpose of this study was to eva...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/1476830515Y.0000000033

    authors: Pessoa D,Cruz R,Machado B,Tenorio B,Nogueira R

    更新日期:2016-06-01 00:00:00

  • Vitamin D metabolites, D3 and D2, and their independent associations with depression symptoms among adults in the United States.

    abstract::Background: The two metabolites of vitamin D; serum 25-hydroxyvitamin D3 (25(OH)D3) and D2 (25(OH)D2), and their independent roles in mood regulation are unexplored. This study aims to examine 25(OH)D3 and 25(OH)D2 and their interplay with depression symptoms. Materials and Methods: Utilizing data from the U.S. Nation...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2020.1794422

    authors: Bigman G

    更新日期:2020-07-20 00:00:00

  • Green tea and vitamin C ameliorate some neuro-functional and biochemical signs of arsenic toxicity in rats.

    abstract:BACKGROUND/OBJECTIVES:Nervous system damage is one of the consequences of oral exposure to waterborne inorganic arsenic. In this work, the role of oxidative status in the neurotoxicity of arsenic and the possible role of two foodborne antioxidants in ameliorating arsenic-related oxidative stress were investigated. MET...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/1476830514Y.0000000151

    authors: Sárközi K,Papp A,Horváth E,Máté Z,Ferencz Á,Hermesz E,Krisch J,Paulik E,Szabó A

    更新日期:2016-01-01 00:00:00

  • Feeding patterns and meal microstructure during development of a taste aversion to a threonine devoid diet.

    abstract::Food intake decreases and a conditioned taste aversion is induced when rats are fed a diet that is devoid of an indispensable amino acid. The purpose of this study was to characterize the meal patterns associated with (1) the onset of anorexia after the initial recognition of a threonine deficiency and (2) after the d...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/10284150290032003

    authors: Feurté S,Tomé D,Gietzen DW,Even PC,Nicolaïdis S,Fromentin G

    更新日期:2002-09-01 00:00:00

  • Polyunsaturated fatty acids levels and initial presentation of somatic symptoms induced by interferon-alpha therapy in patients with chronic hepatitis C viral infection.

    abstract:OBJECTIVES:Somatic symptoms are common in depressive disorder and are similar to sickness behaviors due to inflammatory activation after cytokine administration. Omega-3 polyunsaturated fatty acids (PUFAs) are natural anti-inflammatory agents and may reduce inflammation-induced behavioral changes. The aim of this study...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.2015.1123378

    authors: Chang JP,Lai HC,Yang HT,Su WP,Peng CY,Gałecki P,Walczewska A,Pariante CM,Su KP

    更新日期:2017-06-01 00:00:00

  • Volume of the Sexually Dimorphic Nucleus of the Preoptic Area in Rats Exposed to a Maternal High Fat Diet.

    abstract::Mice and rats exposed to a maternal diet high in fat have an increased risk of reproductive system tumors later in life. To test whether a part of the hypothalamus associated with sex differentiation, the sexually dimorphic nucleus of the preoptic area (SDN-POA), might be involved, this nucleus was measured in the off...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1080/1028415X.1999.11747258

    authors: Walker BE

    更新日期:1999-01-01 00:00:00

  • Vitamin B12-responsive neuropathies: A case series.

    abstract:OBJECTIVES:Neuropathies often accompany vitamin B12 deficiency. Since many neuropathies are linked to oxidative stress and since B12 has both antioxidant and neurotrophic properties, B12 may also be effective treatment in non-deficient subjects. Thus, the characteristics and predictors of B12-responsive neuropathies an...

    journal_title:Nutritional neuroscience

    pub_type: 杂志文章

    doi:10.1179/1476830515Y.0000000006

    authors: Solomon LR

    更新日期:2016-05-01 00:00:00