Abstract:
:ABSTRACTObjectives: One factor contributing to the development of obesity is overeating palatable food. The palatability of food is driven by specific energy yielding combinations and flavor profiles that may contribute to its overconsumption. In rodents, restricted access to palatable food (PF) is a strong stimulus to trigger binge-type eating behavior (BTE), food anticipatory activity (FAA), effort behaviors and withdrawal symptoms. This is accompanied by plastic changes in corticolimbic areas associated with motivation and reward responses. Palatable food contains mainly a mixture of fat and sugar, thus, the contribution of each macronutrient for the behavioral and neuronal changes is unclear. Methods: In this study, Wistar rats were exposed to restricted access to 50% fat rich diet (FRD) or 50% sugar rich diet (SRD) in order to compare the intensity of BTE, FAA, effort behaviors and withdrawal responses. Results: In corticolimbic areas, c-Fos activation and ΔFosB accumulation were evaluated. After an acute exposition, rats ate more SRD than FRD, but FDR stimulated higher c-Fos. After chronic administration, the FDR group exhibited higher levels of BTE and FAA; this was associated with higher c-Fos and accumulation of ΔFosB in the corticolimbic system. Similar effects in the FRD group were observed after one week of withdrawal. Discussion: Present data indicate that the fat rich diet is a stronger stimulus than the sugar rich diet for the development of wanting behavior for reward and the underlying plastic changes in the corticolimbic system. The differential effects may be due to the differing caloric density of the diets.
journal_name
Nutr Neuroscijournal_title
Nutritional neuroscienceauthors
Espitia-Bautista E,Escobar Cdoi
10.1080/1028415X.2019.1651104subject
Has Abstractpub_date
2019-08-16 00:00:00pages
1-12eissn
1028-415Xissn
1476-8305pub_type
杂志文章abstract:OBJECTIVE:Our aim was to investigate the effects of Spirulina on BV-2 microglial cell cytotoxicity and inflammatory genes expression. METHODS:BV-2 microglial cells were treated with lipopolysaccharide (LPS) (1 µg/ml) and various concentrations of Spirulina platensis water extract or its active component (C-phycocyanin...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/1476830512Y.0000000020
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the nutritional status of children with SMA types II and III in a Chinese population. METHODS:We performed a retrospective medical record review of prospectively collected data from children with SMA types II and III in a single centre. We analysed data including clinical parameters, anthropometr...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2020.1871212
更新日期:2021-01-23 00:00:00
abstract::Objectives: Ghrelin acts on a variety of central- and peripheral organs causing an orexigenic effect, conclusively followed by increased caloric intake. Recent studies have indicated that ghrelin's function as an orexigenic agent does not entirely reflect the full functional properties of the peptide. Specifically, gh...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2020.1863740
更新日期:2020-12-29 00:00:00
abstract:OBJECTIVE:The purpose of this study was to assess the association between cerebral infarction (CI), nutritional status, and depression. METHODS:Subjects with and without CI (n = 146; 73 CI vs. 73 non-CI) were recruited from Kyung Hee University Medical Center (Seoul, Korea) and were matched according to age and gende...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/1476830511Y.0000000023
更新日期:2012-01-01 00:00:00
abstract::Endogenous neuropeptide Y (NPY) levels increase during fasting and before dark onset in rats. The feeding that follows these states elicits the release of serotonin in the lateral hypothalamus (LH), as part of the physiological mechanisms controlling satiety. With the hypothesis that exogenous NPY-induced feeding shou...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/10284150400012794
更新日期:2004-08-01 00:00:00
abstract::Objective: Alzheimer's disease (AD), a neurodegenerative disorder, involves brain insulin signaling cascades and insulin resistance (IR). Because of limited treatment options, new treatment strategies are mandatory. Green coffee bean extract (GCBE) was reported to attenuate IR and improve brain energy metabolism. We a...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2018.1468535
更新日期:2020-01-01 00:00:00
abstract::The present study explored the effects of malnutrition and nutritional rehabilitation on the response to glucose in hypothalamic nuclei involved in metabolic homeostasis. Male Wistar rats were malnourished during gestation-lactation (MGL) or at weaning to 55 days (MPW). Two groups of rats were rehabilitated with a bal...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/147683010X12611460764246
更新日期:2010-08-01 00:00:00
abstract::A debate is open in the literature concerning the safety of low (dietary) versus high (intoxicating or addicting) alcohol consumption. Epidemiological data do indeed suggest that moderate ethanol intake may have beneficial effects, at least at cardiovascular level. On the other hand there are few data on the effect of...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.1998.11747224
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVES:Stress in known to alter hormonal systems. Pharmacological doses of tryptophan, the essential amino acid precursor of serotonin, increase circulating leptin and decrease ghrelin in normal healthy adults. Because systemically injected leptin inhibits stress-induced behavioral deficits and systemically injecte...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2017.1395551
更新日期:2019-06-01 00:00:00
abstract::Background: Essential fatty acids (EFAs) and non-essential fatty acids (nEFAs) exert experimental and clinical neuroprotection in neurodegenerative diseases. The main EFAs, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), nEFAs, and oleic acid (OA) contained in olive and fish oils are inserted into the cell me...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2019.1584692
更新日期:2021-01-01 00:00:00
abstract::Background and objective: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder for which no treatments exist. Fragile X syndrome (FXS) is the most common form of inherited mental retardation and the most frequent monogenic cause of ASD. Given the lack of pharmacological treatments for ASD, increasin...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2020.1819107
更新日期:2020-09-11 00:00:00
abstract::The kynurenine (KYN) pathway of tryptophan metabolism produces several neuroactive metabolites, including 3-hydroxykynurenine (3HK). The pathway is subject to regulation by a number of effectors including pregnancy and availability of vitamin B-6. Vitamin B-6 depleted humans and animals excrete abnormally high concent...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2000.11747309
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVES:The green seaweed Ulva sp. contains a large amount of ulvans, a family of sulphated polysaccharides. The present study was designed to investigate in rats the antidepressant- and anxiolytic-like effects of a hydrophilic extract of Ulva sp. (MSP) containing about 45% of ulvans. METHODS:After a 14-day adminis...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2016.1276704
更新日期:2018-05-01 00:00:00
abstract:PURPOSE:The Mediterranean diet has been postulated as a protective factor against different diseases including stroke. Thus, an epidemiological study in a Mediterranean country, such as Spain, focused on diet may offer new insights of the potential benefits of this nutritional pattern to prevent the onset of cerebrovas...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/10284150290007047
更新日期:2002-02-01 00:00:00
abstract::Objectives: A strong rise of the fructose content in the human diet occurred in the last decade, as corn syrup is widely used as a sweetener for beverages and processed food. Since young people make a widespread consumption of added sugars, we evaluated the effects of a two weeks fructose-rich diet on brain redox home...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2018.1501532
更新日期:2020-04-01 00:00:00
abstract::The objective of this study was to determine whether an essential fatty acid (EFA)-deficient diet (saturated fat) fed during development would alter the pattern of dendritic growth in pyramidal neurons of mouse occipital cortex. Pregnant and lactating mice were fed either a saturated fat or control diet throughout pre...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.1998.11747212
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:Major depressive disorder is a debilitating and recurrent psychiatric disorder. Blueberries have several biological properties, including neuroprotective effects, through antioxidant and anti-inflammatory actions. The aim of this study was to evaluate the effect of blueberry extract on depressive-like behavio...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2020.1819104
更新日期:2020-09-21 00:00:00
abstract::Objective: Possible effects of the vagus inhibition and stimulation on the hypothalamic nuclei, myenteric plexes and the vagus nerve were investigated. Methods: The female rats divided to the inhibition (INH), stimulation (STI) and, sham (SHAM) groups were fed with high fat diet (including 40% of energy from animal fa...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2020.1809875
更新日期:2020-10-09 00:00:00
abstract::Newborn rats maintain mother-litter bonds by using olfactory signals. At birth, units in the olfactory glomeruli (OG) are immature and vulnerable to noxious epigenetic factors like undernutrition. Because little is known about the effects of neonatal undernutrition upon the OG morphological organization, different OG ...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/10284150500506042
更新日期:2006-02-01 00:00:00
abstract::The effects of prenatal cocaine and protein malnutrition were examined on acquisition of the radial arm maze in adult male Sprague-Dawley rats whose mothers were provided with a 6% casein, a 25% casein or a standard chow diet and cocaine (30mg/kg) or saline injections beginning 5 weeks prior to mating and continuing t...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.1999.11747269
更新日期:1999-01-01 00:00:00
abstract::The effects of iodine deficiency on growth and development are known as the iodine deficiency disorders (IDDs). Most common is goitre at all ages, but most significant are the effects on brain development during pregnancy. The major effect of iodine deficiency is the clinical syndrome of endemic cretinism characterise...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.1999.11747292
更新日期:1999-01-01 00:00:00
abstract::The treatment of resistant depression has involved the use of various adjuncts in addition to the antidepressant, such as lithium or liothyronine (T3). This case report describes a woman with a history of chronic depression (dysthymic disorder), unresponsive to a number of traditional antidepressants, who was treated ...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.1998.11747241
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:Coffee is one of the most widely consumed beverages worldwide. Aim of this study was to investigate short-term effects of espresso coffee on heart rate variability (HRV), a marker of vagal activity, in healthy habitual and non-habitual coffee consumers. METHODS:Seventy-seven healthy subjects (38 habitual and...
journal_title:Nutritional neuroscience
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1179/1476830515Y.0000000018
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:The consumption of hyperlipidic diets has grown markedly in recent decades, and several studies have linked this consumption with the development of neurodegenerative diseases. Conversely, hyperlipidic diets have been used as an alternative therapy for refractory epilepsy. The purpose of this study was to eva...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/1476830515Y.0000000033
更新日期:2016-06-01 00:00:00
abstract::Background: The two metabolites of vitamin D; serum 25-hydroxyvitamin D3 (25(OH)D3) and D2 (25(OH)D2), and their independent roles in mood regulation are unexplored. This study aims to examine 25(OH)D3 and 25(OH)D2 and their interplay with depression symptoms. Materials and Methods: Utilizing data from the U.S. Nation...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2020.1794422
更新日期:2020-07-20 00:00:00
abstract:BACKGROUND/OBJECTIVES:Nervous system damage is one of the consequences of oral exposure to waterborne inorganic arsenic. In this work, the role of oxidative status in the neurotoxicity of arsenic and the possible role of two foodborne antioxidants in ameliorating arsenic-related oxidative stress were investigated. MET...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/1476830514Y.0000000151
更新日期:2016-01-01 00:00:00
abstract::Food intake decreases and a conditioned taste aversion is induced when rats are fed a diet that is devoid of an indispensable amino acid. The purpose of this study was to characterize the meal patterns associated with (1) the onset of anorexia after the initial recognition of a threonine deficiency and (2) after the d...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/10284150290032003
更新日期:2002-09-01 00:00:00
abstract:OBJECTIVES:Somatic symptoms are common in depressive disorder and are similar to sickness behaviors due to inflammatory activation after cytokine administration. Omega-3 polyunsaturated fatty acids (PUFAs) are natural anti-inflammatory agents and may reduce inflammation-induced behavioral changes. The aim of this study...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.2015.1123378
更新日期:2017-06-01 00:00:00
abstract::Mice and rats exposed to a maternal diet high in fat have an increased risk of reproductive system tumors later in life. To test whether a part of the hypothalamus associated with sex differentiation, the sexually dimorphic nucleus of the preoptic area (SDN-POA), might be involved, this nucleus was measured in the off...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1080/1028415X.1999.11747258
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVES:Neuropathies often accompany vitamin B12 deficiency. Since many neuropathies are linked to oxidative stress and since B12 has both antioxidant and neurotrophic properties, B12 may also be effective treatment in non-deficient subjects. Thus, the characteristics and predictors of B12-responsive neuropathies an...
journal_title:Nutritional neuroscience
pub_type: 杂志文章
doi:10.1179/1476830515Y.0000000006
更新日期:2016-05-01 00:00:00